TRANSDERMAL PENETRATION ENHANCERS
The invention provides compounds based on ceramide analogues of the general the general formula (I), wherein R1= H or CH2OH; R2 = C8 to C16 alkyl; R3 = C7 to C15 alkyl, cis-heptadec-8-en-1-yl, CH(R1)NHCOR4, CH=CHCOOR4 or CH(OH)CH(OH)COOR4; R4 = C7 to C16 alkyl. The compounds of the general formula...
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| creator | DOLEZAL, PAVEL VAVROVA, KATERINA HRABALEK, ALEXANDR HOLAS, TOMAS |
| description | The invention provides compounds based on ceramide analogues of the general the general formula (I), wherein R1= H or CH2OH; R2 = C8 to C16 alkyl; R3 = C7 to C15 alkyl, cis-heptadec-8-en-1-yl, CH(R1)NHCOR4, CH=CHCOOR4 or CH(OH)CH(OH)COOR4; R4 = C7 to C16 alkyl. The compounds of the general formula (I) are used as transdermal penetration enhancers. Pharmaceutical and cosmetic compositions, containing ceramide analogues of the general formula (I) in the amount from 0.1 to 5.0 w/w percent, preferably in the amount from 0.1 to 1.0 w/w percent.
L'invention concerne des composés à base d'analogues de céramide représentés par la formule (I) dans laquelle R1= H ou CH2OH; R2 = C8-16 alkyle; R3 = C7-15 alkyle, cis-heptadec-8-en-1-yl, CH(R1)NHCOR4, CH=CHCOOR4 ou CH(OH)CH(OH)COOR4; R4 = C7-16 alkyle. Les composés représentés par la formule (I) sont utilisés comme activateurs de pénétration transdermique. L'invention concerne également des compositions pharmaceutiques et cosmétiques contenant les analogues de céramide représentés par la formule (I) selon une quantité comprise entre 0,1 et 5,0% en poids, de préférence, selon une quantité comprise entre 0,1 et 1,0% en poids. |
| format | Patent |
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L'invention concerne des composés à base d'analogues de céramide représentés par la formule (I) dans laquelle R1= H ou CH2OH; R2 = C8-16 alkyle; R3 = C7-15 alkyle, cis-heptadec-8-en-1-yl, CH(R1)NHCOR4, CH=CHCOOR4 ou CH(OH)CH(OH)COOR4; R4 = C7-16 alkyle. Les composés représentés par la formule (I) sont utilisés comme activateurs de pénétration transdermique. L'invention concerne également des compositions pharmaceutiques et cosmétiques contenant les analogues de céramide représentés par la formule (I) selon une quantité comprise entre 0,1 et 5,0% en poids, de préférence, selon une quantité comprise entre 0,1 et 1,0% en poids.</description><edition>7</edition><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040902&DB=EPODOC&CC=WO&NR=2004074235A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040902&DB=EPODOC&CC=WO&NR=2004074235A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DOLEZAL, PAVEL</creatorcontrib><creatorcontrib>VAVROVA, KATERINA</creatorcontrib><creatorcontrib>HRABALEK, ALEXANDR</creatorcontrib><creatorcontrib>HOLAS, TOMAS</creatorcontrib><title>TRANSDERMAL PENETRATION ENHANCERS</title><description>The invention provides compounds based on ceramide analogues of the general the general formula (I), wherein R1= H or CH2OH; R2 = C8 to C16 alkyl; R3 = C7 to C15 alkyl, cis-heptadec-8-en-1-yl, CH(R1)NHCOR4, CH=CHCOOR4 or CH(OH)CH(OH)COOR4; R4 = C7 to C16 alkyl. The compounds of the general formula (I) are used as transdermal penetration enhancers. Pharmaceutical and cosmetic compositions, containing ceramide analogues of the general formula (I) in the amount from 0.1 to 5.0 w/w percent, preferably in the amount from 0.1 to 1.0 w/w percent.
L'invention concerne des composés à base d'analogues de céramide représentés par la formule (I) dans laquelle R1= H ou CH2OH; R2 = C8-16 alkyle; R3 = C7-15 alkyle, cis-heptadec-8-en-1-yl, CH(R1)NHCOR4, CH=CHCOOR4 ou CH(OH)CH(OH)COOR4; R4 = C7-16 alkyle. Les composés représentés par la formule (I) sont utilisés comme activateurs de pénétration transdermique. L'invention concerne également des compositions pharmaceutiques et cosmétiques contenant les analogues de céramide représentés par la formule (I) selon une quantité comprise entre 0,1 et 5,0% en poids, de préférence, selon une quantité comprise entre 0,1 et 1,0% en poids.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAMCXL0C3ZxDfJ19FEIcPVzBfJDPP39FFz9PBz9nF2DgnkYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXy4v5GBgYmBuYmRsamjoTFxqgC5YSNL</recordid><startdate>20040902</startdate><enddate>20040902</enddate><creator>DOLEZAL, PAVEL</creator><creator>VAVROVA, KATERINA</creator><creator>HRABALEK, ALEXANDR</creator><creator>HOLAS, TOMAS</creator><scope>EVB</scope></search><sort><creationdate>20040902</creationdate><title>TRANSDERMAL PENETRATION ENHANCERS</title><author>DOLEZAL, PAVEL ; VAVROVA, KATERINA ; HRABALEK, ALEXANDR ; HOLAS, TOMAS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2004074235A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2004</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>DOLEZAL, PAVEL</creatorcontrib><creatorcontrib>VAVROVA, KATERINA</creatorcontrib><creatorcontrib>HRABALEK, ALEXANDR</creatorcontrib><creatorcontrib>HOLAS, TOMAS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DOLEZAL, PAVEL</au><au>VAVROVA, KATERINA</au><au>HRABALEK, ALEXANDR</au><au>HOLAS, TOMAS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TRANSDERMAL PENETRATION ENHANCERS</title><date>2004-09-02</date><risdate>2004</risdate><abstract>The invention provides compounds based on ceramide analogues of the general the general formula (I), wherein R1= H or CH2OH; R2 = C8 to C16 alkyl; R3 = C7 to C15 alkyl, cis-heptadec-8-en-1-yl, CH(R1)NHCOR4, CH=CHCOOR4 or CH(OH)CH(OH)COOR4; R4 = C7 to C16 alkyl. The compounds of the general formula (I) are used as transdermal penetration enhancers. Pharmaceutical and cosmetic compositions, containing ceramide analogues of the general formula (I) in the amount from 0.1 to 5.0 w/w percent, preferably in the amount from 0.1 to 1.0 w/w percent.
L'invention concerne des composés à base d'analogues de céramide représentés par la formule (I) dans laquelle R1= H ou CH2OH; R2 = C8-16 alkyle; R3 = C7-15 alkyle, cis-heptadec-8-en-1-yl, CH(R1)NHCOR4, CH=CHCOOR4 ou CH(OH)CH(OH)COOR4; R4 = C7-16 alkyle. Les composés représentés par la formule (I) sont utilisés comme activateurs de pénétration transdermique. L'invention concerne également des compositions pharmaceutiques et cosmétiques contenant les analogues de céramide représentés par la formule (I) selon une quantité comprise entre 0,1 et 5,0% en poids, de préférence, selon une quantité comprise entre 0,1 et 1,0% en poids.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| title | TRANSDERMAL PENETRATION ENHANCERS |
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