THE USE OF ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES IN THE TREATMENT OF CHRONIC AND NEUROPATHIC PAIN, MIGRAINE HEADACHES, AND URGE, STRESS AND MIXED URINARY INCONTINENCE

THE USE OF ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES IN THE TREATMENT OF CHRONIC AND NEUROPATHIC PAIN, MIGRAINE HEADACHES, AND URGE, STRESS AND MIXED URINARY INCONTINENCE

Provided herein are methods of using compounds of formula (1) that are aryl- and heteroaryl-substituted tetrahydroisoquinolines, for the treatment of chronic and neuropathic pain, the treatment and prevention of migraine headache, and the treatment of stress, urge and mixed urinary incontinence. L&#...

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Hauptverfasser: FRAIL, DONALD, EDWARD, ARNERIC, STEPHEN, PETER, WISHKA, DONN, GREGORY, WONG, ERIK, HO, FONG, BECK, JAMES, PETER
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided herein are methods of using compounds of formula (1) that are aryl- and heteroaryl-substituted tetrahydroisoquinolines, for the treatment of chronic and neuropathic pain, the treatment and prevention of migraine headache, and the treatment of stress, urge and mixed urinary incontinence. L'invention concerne des procédés utilisant des composés de la formule (I) qui sont des tétrahydroisoquinoléines à substitution aryle et hétéroaryle dans le traitement de douleurs chroniques et neurpathiques, le traitement et la prévention de céphalée migraineuse, et le traitement d'incontinence urinaire d'effort, par impériosité et mixte.