MP21S AS MODIFIERS OF THE P21 PATHWAY AND METHODS OF USE

MP21S AS MODIFIERS OF THE P21 PATHWAY AND METHODS OF USE

Human MP21 genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of MP21 are provided. Les gènes humains MP21...

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Bibliographische Detailangaben
Hauptverfasser: AMUNDSEN, CRAIG, D, HAI, BING, FRIEDMAN, LORI, LICKTEIG, KIM, JOO, DANIEL, M, ADAMKEWICZ, JOANNE, I, KIDD, THOMAS, ZHANG, HAIGUANG, ROCHE, SIOBHAN, FRANCIS-LANG, HELEN, HAMMONDS, GLENN, R., JR
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Zusammenfassung:Human MP21 genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of MP21 are provided. Les gènes humains MP21 sont identifiés comme modulateurs de la voie p21 et ils constituent par conséquent des cibles thérapeutiques pour les troubles associés à une fonction p21 défectueuse. Cette invention concerne également des procédés servant à identifier des modulateurs de p21, qui consistent à effectuer le criblage d'agents qui modulent l'activité du gène MP21. .