MORPHOLINYLMETHYLUREAS CCR-3 RECEPTOR ANTAGONIST

Compounds of formula (I): wherein:R represents C3-8 cycloalkyl-Y -, aryl-Y -, heteroaryl-Y -, aryl- G-Y -, heteroaryl-G-Y -, C1-6 alkyl-G-Y -, J -Y -, R R N-Y -, R R N-CO-Y - or R -CONR -Y -; Q represents -(CR R )(CR R )t-, wherein t represents an integer from 0 to 3;R and R independently represent hydrogen or C1-6 alkyl;X represents ethylene or a group of formula CRR wherein R and R independently represent hydrogen or C1-4 alkyl or R and R may together with the carbon atom to which they are attached form a C3-8 cycloalkyl group; R and R independently represent hydrogen or C1-4 alkyl; Z represents a bond, CO, SO2, CR R (CH2)n, (CH2)nCR R , CR R (CH2)nO, CR R (CH2)nS, CR R (CH2)nCO, COCR R (CH2)n or SO2CR R (CH2)n; R represents aryl, heteroaryl or aryl-C2-6 alkenyl-; R represents hydrogen, C1-4 alkyl, CONR R or COOC1-6 alkyl;a and b represent 1 or 2, such that a+b represents 2 or 3;G represents -S-, -SO2-, -SO2NR , -NR SO2 or -NR -; n represents an integer from 0 to 4; J independently represents a moiety of formula (K): wherein X represents oxygen, NR or sulphur, X represents CH2, oxygen, NR or sulphur, m represents an integer from 1 to 3, m represents an integer from 1 to 3, provided that m +m is in the range from 3 to 5, also provided that when both X and X represent oxygen, NR , NR or sulphur, m and m must both not equal less than 2, wherein K is optionally substituted by one or more (eg. 1 or 2) -Y -aryl, -Y -heteroaryl, -Y -CO-aryl, -Y -CO-heteroaryl, -C1-6 alkyl, -Y -COOC1-6 alkyl, -Y -COC1-6 alkyl, -Y -W, -Y -CO-W, -Y -NR R , -Y -CONR R , hydroxy, oxo, -Y -SO2NR R , -Y -SO2C1-6 alkyl, -Y -SO2aryl, -Y -SO2heteroaryl, -Y -NR C1-6 alkyl, -Y -NR SO2C1-6 alkyl, -Y -NR CONR R , -Y -NR COOR or -Y -OCONR R groups, and is optionally fused to a monocyclic aryl or heteroaryl ring;R , R , R , R , R , R and R