BRYOSTATINS, BRYOPYRANS AND POLYKETIDES: COMPOSITIONS AND METHODS
The present invention provides nucleic acid molecules that encode polypeptides that catalyze the synthesis of bioactive compounds, such as polyketides including bryopyran rings, such as bryostatins. Also provided is a composition including at least one nucleic acid molecule that encodes at least one...
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| creator | WAGGONER, LAURA, E HAYGOOD, MARGO SHERMAN, DAVID, H ANDERSON, CHRISTINE LIU, HAIBIN HILDEBRAND, MARK |
| description | The present invention provides nucleic acid molecules that encode polypeptides that catalyze the synthesis of bioactive compounds, such as polyketides including bryopyran rings, such as bryostatins. Also provided is a composition including at least one nucleic acid molecule that encodes at least one polypeptide that catalyzes at least one step in the synthesis of at least one polyketide such as a bryopyran ring, wherein said at least one nucleic acid molecule is derived from at least one marine organism.
La présente invention concerne des molécules d'acide nucléique codantes pour des polypeptides qui catalysent la synthèse de composés bioactifs, tels que des polykétides comprenant des cycles bryopyrane, des bryostatines, par exemple. Cette invention concerne aussi une composition comprenant au moins une molécule d'acide nucléique codante pour au moins un polypeptide qui catalyse dans au moins une étape de la synthèse d'au moins une polykétide telle qu'un cycle bryopyrane, cette molécule d'acide nucléique étant dérivée d'au moins un organisme marin. |
| format | Patent |
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La présente invention concerne des molécules d'acide nucléique codantes pour des polypeptides qui catalysent la synthèse de composés bioactifs, tels que des polykétides comprenant des cycles bryopyrane, des bryostatines, par exemple. Cette invention concerne aussi une composition comprenant au moins une molécule d'acide nucléique codante pour au moins un polypeptide qui catalyse dans au moins une étape de la synthèse d'au moins une polykétide telle qu'un cycle bryopyrane, cette molécule d'acide nucléique étant dérivée d'au moins un organisme marin.</description><edition>7</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; DERIVATIVES THEREOF ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; SUGARS ; VINEGAR ; WINE</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20031204&DB=EPODOC&CC=WO&NR=03099219A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20031204&DB=EPODOC&CC=WO&NR=03099219A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WAGGONER, LAURA, E</creatorcontrib><creatorcontrib>HAYGOOD, MARGO</creatorcontrib><creatorcontrib>SHERMAN, DAVID, H</creatorcontrib><creatorcontrib>ANDERSON, CHRISTINE</creatorcontrib><creatorcontrib>LIU, HAIBIN</creatorcontrib><creatorcontrib>HILDEBRAND, MARK</creatorcontrib><title>BRYOSTATINS, BRYOPYRANS AND POLYKETIDES: COMPOSITIONS AND METHODS</title><description>The present invention provides nucleic acid molecules that encode polypeptides that catalyze the synthesis of bioactive compounds, such as polyketides including bryopyran rings, such as bryostatins. Also provided is a composition including at least one nucleic acid molecule that encodes at least one polypeptide that catalyzes at least one step in the synthesis of at least one polyketide such as a bryopyran ring, wherein said at least one nucleic acid molecule is derived from at least one marine organism.
La présente invention concerne des molécules d'acide nucléique codantes pour des polypeptides qui catalysent la synthèse de composés bioactifs, tels que des polykétides comprenant des cycles bryopyrane, des bryostatines, par exemple. Cette invention concerne aussi une composition comprenant au moins une molécule d'acide nucléique codante pour au moins un polypeptide qui catalyse dans au moins une étape de la synthèse d'au moins une polykétide telle qu'un cycle bryopyrane, cette molécule d'acide nucléique étant dérivée d'au moins un organisme marin.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHB0Cor0Dw5xDPH0C9ZRAHECIoMc_YIVHP1cFAL8fSK9XUM8XVyDrRSc_X0D_IM9Qzz9obK-riEe_i7BPAysaYk5xam8UJqbQdHNNcTZQze1ID8-tbggMTk1L7UkPtzfwNjA0tLI0NLRyJgYNQAjwyun</recordid><startdate>20031204</startdate><enddate>20031204</enddate><creator>WAGGONER, LAURA, E</creator><creator>HAYGOOD, MARGO</creator><creator>SHERMAN, DAVID, H</creator><creator>ANDERSON, CHRISTINE</creator><creator>LIU, HAIBIN</creator><creator>HILDEBRAND, MARK</creator><scope>EVB</scope></search><sort><creationdate>20031204</creationdate><title>BRYOSTATINS, BRYOPYRANS AND POLYKETIDES: COMPOSITIONS AND METHODS</title><author>WAGGONER, LAURA, E ; HAYGOOD, MARGO ; SHERMAN, DAVID, H ; ANDERSON, CHRISTINE ; LIU, HAIBIN ; HILDEBRAND, MARK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO03099219A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2003</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WAGGONER, LAURA, E</creatorcontrib><creatorcontrib>HAYGOOD, MARGO</creatorcontrib><creatorcontrib>SHERMAN, DAVID, H</creatorcontrib><creatorcontrib>ANDERSON, CHRISTINE</creatorcontrib><creatorcontrib>LIU, HAIBIN</creatorcontrib><creatorcontrib>HILDEBRAND, MARK</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WAGGONER, LAURA, E</au><au>HAYGOOD, MARGO</au><au>SHERMAN, DAVID, H</au><au>ANDERSON, CHRISTINE</au><au>LIU, HAIBIN</au><au>HILDEBRAND, MARK</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BRYOSTATINS, BRYOPYRANS AND POLYKETIDES: COMPOSITIONS AND METHODS</title><date>2003-12-04</date><risdate>2003</risdate><abstract>The present invention provides nucleic acid molecules that encode polypeptides that catalyze the synthesis of bioactive compounds, such as polyketides including bryopyran rings, such as bryostatins. Also provided is a composition including at least one nucleic acid molecule that encodes at least one polypeptide that catalyzes at least one step in the synthesis of at least one polyketide such as a bryopyran ring, wherein said at least one nucleic acid molecule is derived from at least one marine organism.
La présente invention concerne des molécules d'acide nucléique codantes pour des polypeptides qui catalysent la synthèse de composés bioactifs, tels que des polykétides comprenant des cycles bryopyrane, des bryostatines, par exemple. Cette invention concerne aussi une composition comprenant au moins une molécule d'acide nucléique codante pour au moins un polypeptide qui catalyse dans au moins une étape de la synthèse d'au moins une polykétide telle qu'un cycle bryopyrane, cette molécule d'acide nucléique étant dérivée d'au moins un organisme marin.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE |
| title | BRYOSTATINS, BRYOPYRANS AND POLYKETIDES: COMPOSITIONS AND METHODS |
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