PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-3-QUINOLINE AND 3-QUINOL-4-ONE CARBONITRILES
There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile is converted...
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| creator | JOHNSON, STEVEN, LAWRENCE BERGER, DAN, MAARTEN WANG, YANONG, DANIEL BOSCHELLI, DIANE, HARRIS |
| description | There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile is converted in three steps to 7-substituted-3-quinolinecarbonitriles which inhibit the action of certain protein kinases and are useful in the treatment of cancer.
Cette invention concerne un procédé de préparation de 3-quinoline carbonitriles substitués en position 7 et d'intermédiaires convenant pour la préparation de 3-quinolinecarbonitriles et des sels pharmaceutiquement acceptables de ces substances. Dans ce procédé, un 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile est transformé à l'issue de trois étapes en 3-quinolinecarbonitriles substitués en position 7 qui inhibent l'action de certaines protéines kinases et sont utiles dans le traitement du cancer. |
| format | Patent |
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Cette invention concerne un procédé de préparation de 3-quinoline carbonitriles substitués en position 7 et d'intermédiaires convenant pour la préparation de 3-quinolinecarbonitriles et des sels pharmaceutiquement acceptables de ces substances. Dans ce procédé, un 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile est transformé à l'issue de trois étapes en 3-quinolinecarbonitriles substitués en position 7 qui inhibent l'action de certaines protéines kinases et sont utiles dans le traitement du cancer.</description><edition>7</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20031113&DB=EPODOC&CC=WO&NR=03093241A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20031113&DB=EPODOC&CC=WO&NR=03093241A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JOHNSON, STEVEN, LAWRENCE</creatorcontrib><creatorcontrib>BERGER, DAN, MAARTEN</creatorcontrib><creatorcontrib>WANG, YANONG, DANIEL</creatorcontrib><creatorcontrib>BOSCHELLI, DIANE, HARRIS</creatorcontrib><title>PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-3-QUINOLINE AND 3-QUINOL-4-ONE CARBONITRILES</title><description>There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile is converted in three steps to 7-substituted-3-quinolinecarbonitriles which inhibit the action of certain protein kinases and are useful in the treatment of cancer.
Cette invention concerne un procédé de préparation de 3-quinoline carbonitriles substitués en position 7 et d'intermédiaires convenant pour la préparation de 3-quinolinecarbonitriles et des sels pharmaceutiquement acceptables de ces substances. Dans ce procédé, un 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile est transformé à l'issue de trois étapes en 3-quinolinecarbonitriles substitués en position 7 qui inhibent l'action de certaines protéines kinases et sont utiles dans le traitement du cancer.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirEKwjAUALs4iPoPzw8ItKYgHdP0hQZKXkxeEKdSJE6ihfr_6KC703HHrYuLD6QxRjAUgHsEH9CroNiSAzJwFDG1kS0nxk5IcUrW0WAdgnId_FzUgj5Jq9CSsxzsgHFbrG7Tfcm7LzfF3iDrXuT5OeZlnq75kV_jmUpZNvJQV6qS_zxvD7Uxag</recordid><startdate>20031113</startdate><enddate>20031113</enddate><creator>JOHNSON, STEVEN, LAWRENCE</creator><creator>BERGER, DAN, MAARTEN</creator><creator>WANG, YANONG, DANIEL</creator><creator>BOSCHELLI, DIANE, HARRIS</creator><scope>EVB</scope></search><sort><creationdate>20031113</creationdate><title>PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-3-QUINOLINE AND 3-QUINOL-4-ONE CARBONITRILES</title><author>JOHNSON, STEVEN, LAWRENCE ; BERGER, DAN, MAARTEN ; WANG, YANONG, DANIEL ; BOSCHELLI, DIANE, HARRIS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO03093241A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2003</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JOHNSON, STEVEN, LAWRENCE</creatorcontrib><creatorcontrib>BERGER, DAN, MAARTEN</creatorcontrib><creatorcontrib>WANG, YANONG, DANIEL</creatorcontrib><creatorcontrib>BOSCHELLI, DIANE, HARRIS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JOHNSON, STEVEN, LAWRENCE</au><au>BERGER, DAN, MAARTEN</au><au>WANG, YANONG, DANIEL</au><au>BOSCHELLI, DIANE, HARRIS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-3-QUINOLINE AND 3-QUINOL-4-ONE CARBONITRILES</title><date>2003-11-13</date><risdate>2003</risdate><abstract>There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile is converted in three steps to 7-substituted-3-quinolinecarbonitriles which inhibit the action of certain protein kinases and are useful in the treatment of cancer.
Cette invention concerne un procédé de préparation de 3-quinoline carbonitriles substitués en position 7 et d'intermédiaires convenant pour la préparation de 3-quinolinecarbonitriles et des sels pharmaceutiquement acceptables de ces substances. Dans ce procédé, un 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile est transformé à l'issue de trois étapes en 3-quinolinecarbonitriles substitués en position 7 qui inhibent l'action de certaines protéines kinases et sont utiles dans le traitement du cancer.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-3-QUINOLINE AND 3-QUINOL-4-ONE CARBONITRILES |
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