IN VITRO ISCHEMIA MODEL
A tissue culture model of oxygen/glucose deprivation induced cell death is provided, which is useful in the analysis of the mechanisms of cell death following brain ischemia, and for screening anti-ischemic drugs. By adopting the in vivo concentrations of calcium, potassium and hydrogen ions to the...
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| creator | CRONBERG, TOBIAS WIELOCH, TADEUSZ RYTTER, ANNA |
| description | A tissue culture model of oxygen/glucose deprivation induced cell death is provided, which is useful in the analysis of the mechanisms of cell death following brain ischemia, and for screening anti-ischemic drugs. By adopting the in vivo concentrations of calcium, potassium and hydrogen ions to the incubation medium a model is established that shows conspicuous similarities with the temporal and special development of cell death in vivo: selective and delayed CA1 damage, and a striking augmentation of damage by high levels of glucose.
Cette invention concerne un modèle de culture tissulaire de mort cellulaire induite par manque d'oxygène/glucose, qui convient bien pour l'analyse des mécanismes de mort cellulaire à la suite d'une ischémie cérébrale et pour le criblage de médicaments anti-ischémiques. L'adaptation des concentrations in vivo d'ions calcium, potassium et hydrogène au support d'incubation permet d'établir un modèle qui fait apparaître de nettes ressemblances avec l'apparition temporale et spéciale de la mort cellulaire in vivo: dégâts sélectifs et différés de la région CA1, et augmentation frappante des dégâts dus à des niveaux élevés de glucose. |
| format | Patent |
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Cette invention concerne un modèle de culture tissulaire de mort cellulaire induite par manque d'oxygène/glucose, qui convient bien pour l'analyse des mécanismes de mort cellulaire à la suite d'une ischémie cérébrale et pour le criblage de médicaments anti-ischémiques. L'adaptation des concentrations in vivo d'ions calcium, potassium et hydrogène au support d'incubation permet d'établir un modèle qui fait apparaître de nettes ressemblances avec l'apparition temporale et spéciale de la mort cellulaire in vivo: dégâts sélectifs et différés de la région CA1, et augmentation frappante des dégâts dus à des niveaux élevés de glucose.</description><edition>7</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040826&DB=EPODOC&CC=WO&NR=03091405A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040826&DB=EPODOC&CC=WO&NR=03091405A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CRONBERG, TOBIAS</creatorcontrib><creatorcontrib>WIELOCH, TADEUSZ</creatorcontrib><creatorcontrib>RYTTER, ANNA</creatorcontrib><title>IN VITRO ISCHEMIA MODEL</title><description>A tissue culture model of oxygen/glucose deprivation induced cell death is provided, which is useful in the analysis of the mechanisms of cell death following brain ischemia, and for screening anti-ischemic drugs. By adopting the in vivo concentrations of calcium, potassium and hydrogen ions to the incubation medium a model is established that shows conspicuous similarities with the temporal and special development of cell death in vivo: selective and delayed CA1 damage, and a striking augmentation of damage by high levels of glucose.
Cette invention concerne un modèle de culture tissulaire de mort cellulaire induite par manque d'oxygène/glucose, qui convient bien pour l'analyse des mécanismes de mort cellulaire à la suite d'une ischémie cérébrale et pour le criblage de médicaments anti-ischémiques. L'adaptation des concentrations in vivo d'ions calcium, potassium et hydrogène au support d'incubation permet d'établir un modèle qui fait apparaître de nettes ressemblances avec l'apparition temporale et spéciale de la mort cellulaire in vivo: dégâts sélectifs et différés de la région CA1, et augmentation frappante des dégâts dus à des niveaux élevés de glucose.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBD39FMI8wwJ8lfwDHb2cPX1dFTw9Xdx9eFhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHh_gbGBpaGJgamjsbGxKgBAMZqH1k</recordid><startdate>20040826</startdate><enddate>20040826</enddate><creator>CRONBERG, TOBIAS</creator><creator>WIELOCH, TADEUSZ</creator><creator>RYTTER, ANNA</creator><scope>EVB</scope></search><sort><creationdate>20040826</creationdate><title>IN VITRO ISCHEMIA MODEL</title><author>CRONBERG, TOBIAS ; WIELOCH, TADEUSZ ; RYTTER, ANNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO03091405A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2004</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CRONBERG, TOBIAS</creatorcontrib><creatorcontrib>WIELOCH, TADEUSZ</creatorcontrib><creatorcontrib>RYTTER, ANNA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CRONBERG, TOBIAS</au><au>WIELOCH, TADEUSZ</au><au>RYTTER, ANNA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IN VITRO ISCHEMIA MODEL</title><date>2004-08-26</date><risdate>2004</risdate><abstract>A tissue culture model of oxygen/glucose deprivation induced cell death is provided, which is useful in the analysis of the mechanisms of cell death following brain ischemia, and for screening anti-ischemic drugs. By adopting the in vivo concentrations of calcium, potassium and hydrogen ions to the incubation medium a model is established that shows conspicuous similarities with the temporal and special development of cell death in vivo: selective and delayed CA1 damage, and a striking augmentation of damage by high levels of glucose.
Cette invention concerne un modèle de culture tissulaire de mort cellulaire induite par manque d'oxygène/glucose, qui convient bien pour l'analyse des mécanismes de mort cellulaire à la suite d'une ischémie cérébrale et pour le criblage de médicaments anti-ischémiques. L'adaptation des concentrations in vivo d'ions calcium, potassium et hydrogène au support d'incubation permet d'établir un modèle qui fait apparaître de nettes ressemblances avec l'apparition temporale et spéciale de la mort cellulaire in vivo: dégâts sélectifs et différés de la région CA1, et augmentation frappante des dégâts dus à des niveaux élevés de glucose.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | IN VITRO ISCHEMIA MODEL |
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