TOLL-LIKE RECEPTOR 11

The invention describes isolated Toll-like receptor 11 ("TLR11 ") and Tolllike receptor 12 ("TLR12") polypeptides as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucle...

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Bibliographische Detailangaben
1. Verfasser:	MEDZHITOV, RUSLAN, M
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention describes isolated Toll-like receptor 11 ("TLR11 ") and Tolllike receptor 12 ("TLR12") polypeptides as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding a TLR11 or a TLR12 polypeptide and methods for producing a TLR11 or a TLR12 polypeptide. Also described are methods for screening for compounds which modulate TLR11 or TLR12 activity. L'invention concerne des polypeptides isolés, à savoir récepteur de type Toll 11 ("TLR11") et récepteur de type Toll 12 ("TLR12"), ainsi que des variants et fragments isolés correspondants, et des acides nucléiques isolés codant ces polypeptides. L'invention concerne également des vecteurs et des cellules hôtes renfermant un acide nucléique qui code ce type de polypeptide, et des procédés relatifs à l'élaboration des polypetides en question. L'invention concerne en outre des procédés relatifs au criblage de composés qui modulent l'activité desdits polypeptides.