NOVEL PROSTATE TUMOR-SPECIFIC PROMOTER
This invention provides novel transcriptional regulatory elements from the human TRPM4 (Transient Receptor Potential-Melastatin 4) gene. These promoter and enhancer elements preferentially activate transcription in prostate tumor cells and tissues as compared to other tissues. Methods and compositio...
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| creator | KRETSCHMER, PETER, J YUAN, TA-TUNG VAN HEUIT, PAMELA, TOY PARRY, GORDON |
| description | This invention provides novel transcriptional regulatory elements from the human TRPM4 (Transient Receptor Potential-Melastatin 4) gene. These promoter and enhancer elements preferentially activate transcription in prostate tumor cells and tissues as compared to other tissues. Methods and compositions are provided to employ TRPM4 promoter elements for prostate tumor-specific expression of therapeutic molecules. Prostate tumor-restricted replicating adenoviral vectors are also provided.
L'invention concerne des nouveaux éléments régulateurs transcriptionnels provenant du gène TRPM4 (mélastatine du potentiel de récepteur transitoire 4) humain. Ces éléments promoteurs et amplificateurs activent de préférence la transcription dans des cellules et des tissus tumoraux prostatiques par contraste avec d'autres tissus. L'invention concerne des méthodes et des compositions destinées à utiliser les éléments promoteurs de TRPM4 pour l'expression spécifique à la tumeur prostatique de molécules thérapeutiques. Elle se rapporte en outre à des vecteurs adénoviraux de réplication restreints à la tumeur prostatique. |
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L'invention concerne des nouveaux éléments régulateurs transcriptionnels provenant du gène TRPM4 (mélastatine du potentiel de récepteur transitoire 4) humain. Ces éléments promoteurs et amplificateurs activent de préférence la transcription dans des cellules et des tissus tumoraux prostatiques par contraste avec d'autres tissus. L'invention concerne des méthodes et des compositions destinées à utiliser les éléments promoteurs de TRPM4 pour l'expression spécifique à la tumeur prostatique de molécules thérapeutiques. Elle se rapporte en outre à des vecteurs adénoviraux de réplication restreints à la tumeur prostatique.</description><edition>7</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20031030&DB=EPODOC&CC=WO&NR=03089596A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20031030&DB=EPODOC&CC=WO&NR=03089596A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KRETSCHMER, PETER, J</creatorcontrib><creatorcontrib>YUAN, TA-TUNG</creatorcontrib><creatorcontrib>VAN HEUIT, PAMELA, TOY</creatorcontrib><creatorcontrib>PARRY, GORDON</creatorcontrib><title>NOVEL PROSTATE TUMOR-SPECIFIC PROMOTER</title><description>This invention provides novel transcriptional regulatory elements from the human TRPM4 (Transient Receptor Potential-Melastatin 4) gene. These promoter and enhancer elements preferentially activate transcription in prostate tumor cells and tissues as compared to other tissues. Methods and compositions are provided to employ TRPM4 promoter elements for prostate tumor-specific expression of therapeutic molecules. Prostate tumor-restricted replicating adenoviral vectors are also provided.
L'invention concerne des nouveaux éléments régulateurs transcriptionnels provenant du gène TRPM4 (mélastatine du potentiel de récepteur transitoire 4) humain. Ces éléments promoteurs et amplificateurs activent de préférence la transcription dans des cellules et des tissus tumoraux prostatiques par contraste avec d'autres tissus. L'invention concerne des méthodes et des compositions destinées à utiliser les éléments promoteurs de TRPM4 pour l'expression spécifique à la tumeur prostatique de molécules thérapeutiques. Elle se rapporte en outre à des vecteurs adénoviraux de réplication restreints à la tumeur prostatique.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFDz8w9z9VEICPIPDnEMcVUICfX1D9INDnB19nTzdAaJ-_qHuAbxMLCmJeYUp_JCaW4GRTfXEGcP3dSC_PjU4oLE5NS81JL4cH8DYwMLS1NLM0cjY2LUAADv9yQj</recordid><startdate>20031030</startdate><enddate>20031030</enddate><creator>KRETSCHMER, PETER, J</creator><creator>YUAN, TA-TUNG</creator><creator>VAN HEUIT, PAMELA, TOY</creator><creator>PARRY, GORDON</creator><scope>EVB</scope></search><sort><creationdate>20031030</creationdate><title>NOVEL PROSTATE TUMOR-SPECIFIC PROMOTER</title><author>KRETSCHMER, PETER, J ; YUAN, TA-TUNG ; VAN HEUIT, PAMELA, TOY ; PARRY, GORDON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO03089596A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2003</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>KRETSCHMER, PETER, J</creatorcontrib><creatorcontrib>YUAN, TA-TUNG</creatorcontrib><creatorcontrib>VAN HEUIT, PAMELA, TOY</creatorcontrib><creatorcontrib>PARRY, GORDON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KRETSCHMER, PETER, J</au><au>YUAN, TA-TUNG</au><au>VAN HEUIT, PAMELA, TOY</au><au>PARRY, GORDON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL PROSTATE TUMOR-SPECIFIC PROMOTER</title><date>2003-10-30</date><risdate>2003</risdate><abstract>This invention provides novel transcriptional regulatory elements from the human TRPM4 (Transient Receptor Potential-Melastatin 4) gene. These promoter and enhancer elements preferentially activate transcription in prostate tumor cells and tissues as compared to other tissues. Methods and compositions are provided to employ TRPM4 promoter elements for prostate tumor-specific expression of therapeutic molecules. Prostate tumor-restricted replicating adenoviral vectors are also provided.
L'invention concerne des nouveaux éléments régulateurs transcriptionnels provenant du gène TRPM4 (mélastatine du potentiel de récepteur transitoire 4) humain. Ces éléments promoteurs et amplificateurs activent de préférence la transcription dans des cellules et des tissus tumoraux prostatiques par contraste avec d'autres tissus. L'invention concerne des méthodes et des compositions destinées à utiliser les éléments promoteurs de TRPM4 pour l'expression spécifique à la tumeur prostatique de molécules thérapeutiques. Elle se rapporte en outre à des vecteurs adénoviraux de réplication restreints à la tumeur prostatique.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | NOVEL PROSTATE TUMOR-SPECIFIC PROMOTER |
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