CHIMERIC BIRD FROM EMBRYONIC STEM CELLS
Sustained cultures of avian embryonic stem cells are provided. Injection of avian embryonic stem cells into recipient embryos yields chimeras with a significant contribution from the embryonic stem cell phenotype. Transgene encoding exogenous proteins are stably integrated in the embryonic stem cell...
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| creator | VAN DE LAVOIR, MARIE-CECILE HEYER, BABETTE MATHER, CHRISTINE BEEMER, KATHLEEN DIAMOND, JENNIFER MYERS, HEATHER ETCHES, ROBERT, J |
| description | Sustained cultures of avian embryonic stem cells are provided. Injection of avian embryonic stem cells into recipient embryos yields chimeras with a significant contribution from the embryonic stem cell phenotype. Transgene encoding exogenous proteins are stably integrated in the embryonic stem cells and are present in the somatic tissue of the resulting chimeras. The transgenes may encode exogenous proteins expressed in endodermal, ectodermal, mesodermal, or extra embryonic tissue. Breeding the resulting chimera yields transgenic birds whose genome is comprised of exogenous DNA.
L'invention concerne des cultures continues de cellules souches embryonnaires aviaires. Selon l'invention, l'injection de cellules souches embryonnaires dans des embryons récepteurs permet de produire des chimères avec une contribution importante du phénotype dérivé des cellules souches embryonnaires. Des transgènes codant de protéines exogènes sont intégrés de manière stable dans lesdites cellules souches embryonnaires et sont présents dans les tissus somatiques desdites chimères résultantes. Lesdits transgènes peuvent coder des protéines exogènes exprimées dans des tissus endodermiques, ectodermiques, mésodermiques ou extra-embryonnaires. La reproduction des chimères obtenues permet de produire des oiseaux transgéniques dont le génome comprend de l'ADN exogène. |
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L'invention concerne des cultures continues de cellules souches embryonnaires aviaires. Selon l'invention, l'injection de cellules souches embryonnaires dans des embryons récepteurs permet de produire des chimères avec une contribution importante du phénotype dérivé des cellules souches embryonnaires. Des transgènes codant de protéines exogènes sont intégrés de manière stable dans lesdites cellules souches embryonnaires et sont présents dans les tissus somatiques desdites chimères résultantes. Lesdits transgènes peuvent coder des protéines exogènes exprimées dans des tissus endodermiques, ectodermiques, mésodermiques ou extra-embryonnaires. La reproduction des chimères obtenues permet de produire des oiseaux transgéniques dont le génome comprend de l'ADN exogène.</description><edition>7</edition><language>eng ; fre</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BEER ; BIOCHEMISTRY ; CARE OF BIRDS, FISHES, INSECTS ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NEW BREEDS OF ANIMALS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR ; SPIRITS ; TRAPPING ; VINEGAR ; WINE</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20031204&DB=EPODOC&CC=WO&NR=03064627A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20031204&DB=EPODOC&CC=WO&NR=03064627A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VAN DE LAVOIR, MARIE-CECILE</creatorcontrib><creatorcontrib>HEYER, BABETTE</creatorcontrib><creatorcontrib>MATHER, CHRISTINE</creatorcontrib><creatorcontrib>BEEMER, KATHLEEN</creatorcontrib><creatorcontrib>DIAMOND, JENNIFER</creatorcontrib><creatorcontrib>MYERS, HEATHER</creatorcontrib><creatorcontrib>ETCHES, ROBERT, J</creatorcontrib><title>CHIMERIC BIRD FROM EMBRYONIC STEM CELLS</title><description>Sustained cultures of avian embryonic stem cells are provided. Injection of avian embryonic stem cells into recipient embryos yields chimeras with a significant contribution from the embryonic stem cell phenotype. Transgene encoding exogenous proteins are stably integrated in the embryonic stem cells and are present in the somatic tissue of the resulting chimeras. The transgenes may encode exogenous proteins expressed in endodermal, ectodermal, mesodermal, or extra embryonic tissue. Breeding the resulting chimera yields transgenic birds whose genome is comprised of exogenous DNA.
L'invention concerne des cultures continues de cellules souches embryonnaires aviaires. Selon l'invention, l'injection de cellules souches embryonnaires dans des embryons récepteurs permet de produire des chimères avec une contribution importante du phénotype dérivé des cellules souches embryonnaires. Des transgènes codant de protéines exogènes sont intégrés de manière stable dans lesdites cellules souches embryonnaires et sont présents dans les tissus somatiques desdites chimères résultantes. Lesdits transgènes peuvent coder des protéines exogènes exprimées dans des tissus endodermiques, ectodermiques, mésodermiques ou extra-embryonnaires. La reproduction des chimères obtenues permet de produire des oiseaux transgéniques dont le génome comprend de l'ADN exogène.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CARE OF BIRDS, FISHES, INSECTS</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NEW BREEDS OF ANIMALS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</subject><subject>SPIRITS</subject><subject>TRAPPING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB39vD0dQ3ydFZw8gxyUXAL8vdVcPV1Cor09wOKBYe4-io4u_r4BPMwsKYl5hSn8kJpbgZFN9cQZw_d1IL8-NTigsTk1LzUkvhwfwNjAzMTMyNzR2NjYtQAANMKI8M</recordid><startdate>20031204</startdate><enddate>20031204</enddate><creator>VAN DE LAVOIR, MARIE-CECILE</creator><creator>HEYER, BABETTE</creator><creator>MATHER, CHRISTINE</creator><creator>BEEMER, KATHLEEN</creator><creator>DIAMOND, JENNIFER</creator><creator>MYERS, HEATHER</creator><creator>ETCHES, ROBERT, J</creator><scope>EVB</scope></search><sort><creationdate>20031204</creationdate><title>CHIMERIC BIRD FROM EMBRYONIC STEM CELLS</title><author>VAN DE LAVOIR, MARIE-CECILE ; HEYER, BABETTE ; MATHER, CHRISTINE ; BEEMER, KATHLEEN ; DIAMOND, JENNIFER ; MYERS, HEATHER ; ETCHES, ROBERT, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO03064627A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2003</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CARE OF BIRDS, FISHES, INSECTS</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NEW BREEDS OF ANIMALS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</topic><topic>SPIRITS</topic><topic>TRAPPING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>VAN DE LAVOIR, MARIE-CECILE</creatorcontrib><creatorcontrib>HEYER, BABETTE</creatorcontrib><creatorcontrib>MATHER, CHRISTINE</creatorcontrib><creatorcontrib>BEEMER, KATHLEEN</creatorcontrib><creatorcontrib>DIAMOND, JENNIFER</creatorcontrib><creatorcontrib>MYERS, HEATHER</creatorcontrib><creatorcontrib>ETCHES, ROBERT, J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VAN DE LAVOIR, MARIE-CECILE</au><au>HEYER, BABETTE</au><au>MATHER, CHRISTINE</au><au>BEEMER, KATHLEEN</au><au>DIAMOND, JENNIFER</au><au>MYERS, HEATHER</au><au>ETCHES, ROBERT, J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CHIMERIC BIRD FROM EMBRYONIC STEM CELLS</title><date>2003-12-04</date><risdate>2003</risdate><abstract>Sustained cultures of avian embryonic stem cells are provided. Injection of avian embryonic stem cells into recipient embryos yields chimeras with a significant contribution from the embryonic stem cell phenotype. Transgene encoding exogenous proteins are stably integrated in the embryonic stem cells and are present in the somatic tissue of the resulting chimeras. The transgenes may encode exogenous proteins expressed in endodermal, ectodermal, mesodermal, or extra embryonic tissue. Breeding the resulting chimera yields transgenic birds whose genome is comprised of exogenous DNA.
L'invention concerne des cultures continues de cellules souches embryonnaires aviaires. Selon l'invention, l'injection de cellules souches embryonnaires dans des embryons récepteurs permet de produire des chimères avec une contribution importante du phénotype dérivé des cellules souches embryonnaires. Des transgènes codant de protéines exogènes sont intégrés de manière stable dans lesdites cellules souches embryonnaires et sont présents dans les tissus somatiques desdites chimères résultantes. Lesdits transgènes peuvent coder des protéines exogènes exprimées dans des tissus endodermiques, ectodermiques, mésodermiques ou extra-embryonnaires. La reproduction des chimères obtenues permet de produire des oiseaux transgéniques dont le génome comprend de l'ADN exogène.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TRAPPING VINEGAR WINE |
| title | CHIMERIC BIRD FROM EMBRYONIC STEM CELLS |
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