CYCLOHEXANO- AND CYCLOHEPTAPYRAZOLE DERIVATIVE COMPOUNDS, FOR USE IN DISEASES ASSOCIATED WITH THE 5-HT2C RECEPTOR

Disclosed are cyclohexano− and cycloheptapyrazole derivative compounds or purified stereoisomers or stereoisomer mixtures of said compounds and their salts or prodrug forms thereof which have structural formulas (I), (Ia), (II) or (IIa): wherein the variables R, R1, R2, R3 and R4 are as defined in t...

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Hauptverfasser:	CHOI, SOONGYOU, BARYZA, JEREMY, L, LADOUCEUR, GAETAN, H, VELTHUISEN, EMIL, COISH, PHILIP, WANG, YAMIN, COOK, JAMES, H. II
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	CHOI, SOONGYOU BARYZA, JEREMY, L LADOUCEUR, GAETAN, H VELTHUISEN, EMIL COISH, PHILIP WANG, YAMIN COOK, JAMES, H. II
description	Disclosed are cyclohexano− and cycloheptapyrazole derivative compounds or purified stereoisomers or stereoisomer mixtures of said compounds and their salts or prodrug forms thereof which have structural formulas (I), (Ia), (II) or (IIa): wherein the variables R, R1, R2, R3 and R4 are as defined in the specification. The compounds are useful for the treatment or prevention of diseases and or behaviors involving the 5−HT2C receptor. Disclosed are cyclohexano- and cycloheptapyrazole derivative compounds or purified stereoisomers or stereoisomer mixtures of said compounds and their salts or prodrug forms thereof which have structural formulas I, Ia, II or IIa: wherein the variables R, R1, R2, R3 and R4 are as defined in the specification. The compounds are useful for the treatment or prevention of diseases and/or behaviors involving the 5-HT2C receptor. L'invention se rapporte à des composés dérivés de cyclohexano- et cycloheptapyrazole ou à des stéréoisomères purifiés ou mélanges de stéréoisomères de ces composés, ainsi qu'à leurs sels ou formes de type promédicaments. Ces composés sont représentés par les formules structurelles (I), (Ia), (II) ou (IIa), dans lesquelles les variables R, R1, R2, R3, R3' et R4 sont définies dans la spécification. Ces composés s'avèrent utiles pour le traitement ou la prévention des maladies et/ou comportements impliquant le récepteur 5-HT2c.
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The compounds are useful for the treatment or prevention of diseases and/or behaviors involving the 5-HT2C receptor. L'invention se rapporte à des composés dérivés de cyclohexano- et cycloheptapyrazole ou à des stéréoisomères purifiés ou mélanges de stéréoisomères de ces composés, ainsi qu'à leurs sels ou formes de type promédicaments. Ces composés sont représentés par les formules structurelles (I), (Ia), (II) ou (IIa), dans lesquelles les variables R, R1, R2, R3, R3' et R4 sont définies dans la spécification. 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The compounds are useful for the treatment or prevention of diseases and/or behaviors involving the 5-HT2C receptor. L'invention se rapporte à des composés dérivés de cyclohexano- et cycloheptapyrazole ou à des stéréoisomères purifiés ou mélanges de stéréoisomères de ces composés, ainsi qu'à leurs sels ou formes de type promédicaments. Ces composés sont représentés par les formules structurelles (I), (Ia), (II) ou (IIa), dans lesquelles les variables R, R1, R2, R3, R3' et R4 sont définies dans la spécification. 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The compounds are useful for the treatment or prevention of diseases and or behaviors involving the 5−HT2C receptor. Disclosed are cyclohexano- and cycloheptapyrazole derivative compounds or purified stereoisomers or stereoisomer mixtures of said compounds and their salts or prodrug forms thereof which have structural formulas I, Ia, II or IIa: wherein the variables R, R1, R2, R3 and R4 are as defined in the specification. The compounds are useful for the treatment or prevention of diseases and/or behaviors involving the 5-HT2C receptor. L'invention se rapporte à des composés dérivés de cyclohexano- et cycloheptapyrazole ou à des stéréoisomères purifiés ou mélanges de stéréoisomères de ces composés, ainsi qu'à leurs sels ou formes de type promédicaments. Ces composés sont représentés par les formules structurelles (I), (Ia), (II) ou (IIa), dans lesquelles les variables R, R1, R2, R3, R3' et R4 sont définies dans la spécification. 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title	CYCLOHEXANO- AND CYCLOHEPTAPYRAZOLE DERIVATIVE COMPOUNDS, FOR USE IN DISEASES ASSOCIATED WITH THE 5-HT2C RECEPTOR
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