COMPOSITIONS AND METHODS FOR INHIBITING ECCRINE PERSPIRATION IN HUMANS
Non-pathological, physiologically normal sweating is inhibited through use of an a muscarinic anticholinergic amine that blocks parasympathetic stimuli from cholinergic nerve fibers to an innerved sweat gland. The anticholinergic agent is included in a form adapted to be topically applied to commonl...
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| description | Non-pathological, physiologically normal sweating is inhibited through use of an a muscarinic anticholinergic amine that blocks parasympathetic stimuli from cholinergic nerve fibers to an innerved sweat gland. The anticholinergic agent is included in a form adapted to be topically applied to commonly sweaty areas of the body. Side effects are minimized by employing amines which are charged at physiological pH, thereby minimizing their ability to cross biological membranes. The most prefered anticholinergic agents are salts of quaternary amines (quaternary ammonium salts) which are always charged.
La sudation non pathologique, physiologiquement normale, est inhibée au moyen d'une amine anticholinergique muscarinique, qui bloque les stimuli parasympathiques exercés par les fibres nerveuses cholinergiques sur une glande sudoripare innervée. L'agent anticholinergique est contenu dans une forme adaptée à une application de surface sur des zones corporelles généralement sujettes à la sudation. Les effets indésirables sont minimisés par l'emploi d'amines chargées au pH physiologique, ce qui minimise leur capacité à traverser les membranes biologiques. Les agents anticholinergiques préférés sont des sels d'amines quaternaires (sels d'ammonium quaternaire), lesquels sont toujours chargés. |
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La sudation non pathologique, physiologiquement normale, est inhibée au moyen d'une amine anticholinergique muscarinique, qui bloque les stimuli parasympathiques exercés par les fibres nerveuses cholinergiques sur une glande sudoripare innervée. L'agent anticholinergique est contenu dans une forme adaptée à une application de surface sur des zones corporelles généralement sujettes à la sudation. Les effets indésirables sont minimisés par l'emploi d'amines chargées au pH physiologique, ce qui minimise leur capacité à traverser les membranes biologiques. Les agents anticholinergiques préférés sont des sels d'amines quaternaires (sels d'ammonium quaternaire), lesquels sont toujours chargés.</description><edition>7</edition><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030403&DB=EPODOC&CC=WO&NR=03026585A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030403&DB=EPODOC&CC=WO&NR=03026585A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LUKACSKO, ALISON, B</creatorcontrib><title>COMPOSITIONS AND METHODS FOR INHIBITING ECCRINE PERSPIRATION IN HUMANS</title><description>Non-pathological, physiologically normal sweating is inhibited through use of an a muscarinic anticholinergic amine that blocks parasympathetic stimuli from cholinergic nerve fibers to an innerved sweat gland. The anticholinergic agent is included in a form adapted to be topically applied to commonly sweaty areas of the body. Side effects are minimized by employing amines which are charged at physiological pH, thereby minimizing their ability to cross biological membranes. The most prefered anticholinergic agents are salts of quaternary amines (quaternary ammonium salts) which are always charged.
La sudation non pathologique, physiologiquement normale, est inhibée au moyen d'une amine anticholinergique muscarinique, qui bloque les stimuli parasympathiques exercés par les fibres nerveuses cholinergiques sur une glande sudoripare innervée. L'agent anticholinergique est contenu dans une forme adaptée à une application de surface sur des zones corporelles généralement sujettes à la sudation. Les effets indésirables sont minimisés par l'emploi d'amines chargées au pH physiologique, ce qui minimise leur capacité à traverser les membranes biologiques. Les agents anticholinergiques préférés sont des sels d'amines quaternaires (sels d'ammonium quaternaire), lesquels sont toujours chargés.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBz9vcN8A_2DPH09wtWcPRzUfB1DfHwdwlWcPMPUvD08_B0Asr5uSu4OjsHefq5KgS4BgUHeAY5gjQA5RU8Qn0d_YJ5GFjTEnOKU3mhNDeDoptriLOHbmpBfnxqcUFicmpeakl8uL-BsYGRmamFqaORMTFqANB6LKs</recordid><startdate>20030403</startdate><enddate>20030403</enddate><creator>LUKACSKO, ALISON, B</creator><scope>EVB</scope></search><sort><creationdate>20030403</creationdate><title>COMPOSITIONS AND METHODS FOR INHIBITING ECCRINE PERSPIRATION IN HUMANS</title><author>LUKACSKO, ALISON, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO03026585A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2003</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LUKACSKO, ALISON, B</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LUKACSKO, ALISON, B</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITIONS AND METHODS FOR INHIBITING ECCRINE PERSPIRATION IN HUMANS</title><date>2003-04-03</date><risdate>2003</risdate><abstract>Non-pathological, physiologically normal sweating is inhibited through use of an a muscarinic anticholinergic amine that blocks parasympathetic stimuli from cholinergic nerve fibers to an innerved sweat gland. The anticholinergic agent is included in a form adapted to be topically applied to commonly sweaty areas of the body. Side effects are minimized by employing amines which are charged at physiological pH, thereby minimizing their ability to cross biological membranes. The most prefered anticholinergic agents are salts of quaternary amines (quaternary ammonium salts) which are always charged.
La sudation non pathologique, physiologiquement normale, est inhibée au moyen d'une amine anticholinergique muscarinique, qui bloque les stimuli parasympathiques exercés par les fibres nerveuses cholinergiques sur une glande sudoripare innervée. L'agent anticholinergique est contenu dans une forme adaptée à une application de surface sur des zones corporelles généralement sujettes à la sudation. Les effets indésirables sont minimisés par l'emploi d'amines chargées au pH physiologique, ce qui minimise leur capacité à traverser les membranes biologiques. Les agents anticholinergiques préférés sont des sels d'amines quaternaires (sels d'ammonium quaternaire), lesquels sont toujours chargés.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS |
| title | COMPOSITIONS AND METHODS FOR INHIBITING ECCRINE PERSPIRATION IN HUMANS |
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