METHOD AND DIAGNOSTIC KIT FOR THE MOLECULAR DIAGNOSIS OF PHARMACOLOGICALLY RELEVANT GENES
Die vorliegende Erfindung betrifft ein Diagnose-Kit und ein Verfahren zur Bestimmung der Medikamentenverträglichkeit eines Menschen. Das Diagnose-Kit enthält mindestens zwei Paare Oligonukleotide (Reversprimer, Forwardprimer), wobei die beiden Oligonukleotide jedes Paares als Primer zur Amplifikatio...
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| creator | WASCHUETZA, STEFANIE LUSTIG, MICHAEL SCHNAKENBERG, ECKART |
| description | Die vorliegende Erfindung betrifft ein Diagnose-Kit und ein Verfahren zur Bestimmung der Medikamentenverträglichkeit eines Menschen. Das Diagnose-Kit enthält mindestens zwei Paare Oligonukleotide (Reversprimer, Forwardprimer), wobei die beiden Oligonukleotide jedes Paares als Primer zur Amplifikation mittels Polymerasekettenreaktion jeweils eines der beiden komplementären Stränge eines gesuchten DNS-Abschnittes geeignet sind. Der jeweils einem Paar Oligonukleotide zugeordnete gesuchte DNS-Abschnitt ist dabei Teil des Gens eines der menschlichen Enzyme der Phase I und/oder Phase II des Entgiftungsstoffwechsels.
The invention relates to a diagnosis kit and a method for determining a person's tolerance to medicaments. Said diagnosis kit contains at least two pairs of oligonucleotides (reverse primer, forward primer). The two oligonucleotides of each pair are suitable as primers for amplification by means of a polymerase chain reaction of respectively one of the two additional strands of a sought DNA segment. Said sought DNA segment which is respectively associated with a pair of oligonucleotides is part of the gene of a human enzyme of phase I and/or phase II of the detoxification metabolism.
L'invention concerne un kit de diagnostic ainsi qu'un procédé permettant de déterminer la tolérance d'un être humain à des médicaments. Ce kit de diagnostic comprend au moins deux paires d'oligonucléotides (amorce inverse, amorce avant). Les deux oligonucléotides de chaque paire servent d'amorces pour l'amplification par réaction en chaîne de la polymérase de respectivement un des deux brins complémentaires d'un segment DNS recherché. Le segment DNS recherché qui est respectivement associé à une paire d'oligonucléotides représente une partie du gène d'une enzyme humaine de la phase I et/ou de la phase II du processus métabolique de détoxication. |
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The invention relates to a diagnosis kit and a method for determining a person's tolerance to medicaments. Said diagnosis kit contains at least two pairs of oligonucleotides (reverse primer, forward primer). The two oligonucleotides of each pair are suitable as primers for amplification by means of a polymerase chain reaction of respectively one of the two additional strands of a sought DNA segment. Said sought DNA segment which is respectively associated with a pair of oligonucleotides is part of the gene of a human enzyme of phase I and/or phase II of the detoxification metabolism.
L'invention concerne un kit de diagnostic ainsi qu'un procédé permettant de déterminer la tolérance d'un être humain à des médicaments. Ce kit de diagnostic comprend au moins deux paires d'oligonucléotides (amorce inverse, amorce avant). Les deux oligonucléotides de chaque paire servent d'amorces pour l'amplification par réaction en chaîne de la polymérase de respectivement un des deux brins complémentaires d'un segment DNS recherché. Le segment DNS recherché qui est respectivement associé à une paire d'oligonucléotides représente une partie du gène d'une enzyme humaine de la phase I et/ou de la phase II du processus métabolique de détoxication.</description><edition>7</edition><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; COMBINATORIAL CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; TESTING ; THEIR RELEVANT APPARATUS ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030306&DB=EPODOC&CC=WO&NR=03018837A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030306&DB=EPODOC&CC=WO&NR=03018837A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WASCHUETZA, STEFANIE</creatorcontrib><creatorcontrib>LUSTIG, MICHAEL</creatorcontrib><creatorcontrib>SCHNAKENBERG, ECKART</creatorcontrib><title>METHOD AND DIAGNOSTIC KIT FOR THE MOLECULAR DIAGNOSIS OF PHARMACOLOGICALLY RELEVANT GENES</title><description>Die vorliegende Erfindung betrifft ein Diagnose-Kit und ein Verfahren zur Bestimmung der Medikamentenverträglichkeit eines Menschen. Das Diagnose-Kit enthält mindestens zwei Paare Oligonukleotide (Reversprimer, Forwardprimer), wobei die beiden Oligonukleotide jedes Paares als Primer zur Amplifikation mittels Polymerasekettenreaktion jeweils eines der beiden komplementären Stränge eines gesuchten DNS-Abschnittes geeignet sind. Der jeweils einem Paar Oligonukleotide zugeordnete gesuchte DNS-Abschnitt ist dabei Teil des Gens eines der menschlichen Enzyme der Phase I und/oder Phase II des Entgiftungsstoffwechsels.
The invention relates to a diagnosis kit and a method for determining a person's tolerance to medicaments. Said diagnosis kit contains at least two pairs of oligonucleotides (reverse primer, forward primer). The two oligonucleotides of each pair are suitable as primers for amplification by means of a polymerase chain reaction of respectively one of the two additional strands of a sought DNA segment. Said sought DNA segment which is respectively associated with a pair of oligonucleotides is part of the gene of a human enzyme of phase I and/or phase II of the detoxification metabolism.
L'invention concerne un kit de diagnostic ainsi qu'un procédé permettant de déterminer la tolérance d'un être humain à des médicaments. Ce kit de diagnostic comprend au moins deux paires d'oligonucléotides (amorce inverse, amorce avant). Les deux oligonucléotides de chaque paire servent d'amorces pour l'amplification par réaction en chaîne de la polymérase de respectivement un des deux brins complémentaires d'un segment DNS recherché. Le segment DNS recherché qui est respectivement associé à une paire d'oligonucléotides représente une partie du gène d'une enzyme humaine de la phase I et/ou de la phase II du processus métabolique de détoxication.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMBINATORIAL CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQANAsDqL-w_kBQjWDXY_00gSTnCSp0qkUiZNoof4_Lro7veUtRe8pG24AQwONxTZwylbByWbQHCEbAs-OVOcw_oJNwBrOBqNHxY5bq9C5HiI5umDI0FKgtBaL-_iYy-brSmw1ZWV2ZXoNZZ7GW3mW93DlSlb7upZHPMh_zgcMMTGL</recordid><startdate>20030306</startdate><enddate>20030306</enddate><creator>WASCHUETZA, STEFANIE</creator><creator>LUSTIG, MICHAEL</creator><creator>SCHNAKENBERG, ECKART</creator><scope>EVB</scope></search><sort><creationdate>20030306</creationdate><title>METHOD AND DIAGNOSTIC KIT FOR THE MOLECULAR DIAGNOSIS OF PHARMACOLOGICALLY RELEVANT GENES</title><author>WASCHUETZA, STEFANIE ; LUSTIG, MICHAEL ; SCHNAKENBERG, ECKART</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO03018837A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2003</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMBINATORIAL CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WASCHUETZA, STEFANIE</creatorcontrib><creatorcontrib>LUSTIG, MICHAEL</creatorcontrib><creatorcontrib>SCHNAKENBERG, ECKART</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WASCHUETZA, STEFANIE</au><au>LUSTIG, MICHAEL</au><au>SCHNAKENBERG, ECKART</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD AND DIAGNOSTIC KIT FOR THE MOLECULAR DIAGNOSIS OF PHARMACOLOGICALLY RELEVANT GENES</title><date>2003-03-06</date><risdate>2003</risdate><abstract>Die vorliegende Erfindung betrifft ein Diagnose-Kit und ein Verfahren zur Bestimmung der Medikamentenverträglichkeit eines Menschen. Das Diagnose-Kit enthält mindestens zwei Paare Oligonukleotide (Reversprimer, Forwardprimer), wobei die beiden Oligonukleotide jedes Paares als Primer zur Amplifikation mittels Polymerasekettenreaktion jeweils eines der beiden komplementären Stränge eines gesuchten DNS-Abschnittes geeignet sind. Der jeweils einem Paar Oligonukleotide zugeordnete gesuchte DNS-Abschnitt ist dabei Teil des Gens eines der menschlichen Enzyme der Phase I und/oder Phase II des Entgiftungsstoffwechsels.
The invention relates to a diagnosis kit and a method for determining a person's tolerance to medicaments. Said diagnosis kit contains at least two pairs of oligonucleotides (reverse primer, forward primer). The two oligonucleotides of each pair are suitable as primers for amplification by means of a polymerase chain reaction of respectively one of the two additional strands of a sought DNA segment. Said sought DNA segment which is respectively associated with a pair of oligonucleotides is part of the gene of a human enzyme of phase I and/or phase II of the detoxification metabolism.
L'invention concerne un kit de diagnostic ainsi qu'un procédé permettant de déterminer la tolérance d'un être humain à des médicaments. Ce kit de diagnostic comprend au moins deux paires d'oligonucléotides (amorce inverse, amorce avant). Les deux oligonucléotides de chaque paire servent d'amorces pour l'amplification par réaction en chaîne de la polymérase de respectivement un des deux brins complémentaires d'un segment DNS recherché. Le segment DNS recherché qui est respectivement associé à une paire d'oligonucléotides représente une partie du gène d'une enzyme humaine de la phase I et/ou de la phase II du processus métabolique de détoxication.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING THEIR RELEVANT APPARATUS TRANSPORTING VINEGAR WINE |
| title | METHOD AND DIAGNOSTIC KIT FOR THE MOLECULAR DIAGNOSIS OF PHARMACOLOGICALLY RELEVANT GENES |
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