AMPLIFICATION OF ANALYTE DETECTION WITH PASSIVATED ENHANCING SURFACES HAVING RECEPTORS
This invention comprises devices, compositions and methods for quantitative detecting analytes in complex solutions by Raman spectroscopy. Passivating agents associated with enhancing surfaces can decrease direct, non-specific interaction between analytes and the enhancing surface. By decreasing dir...
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| creator | KREIMER, DAVID, I GINZBURG, LEV, V YEVIN, OLEG, A |
| description | This invention comprises devices, compositions and methods for quantitative detecting analytes in complex solutions by Raman spectroscopy. Passivating agents associated with enhancing surfaces can decrease direct, non-specific interaction between analytes and the enhancing surface. By decreasing direct interaction between analytes and enhancing surfaces, relatively more selective detection of the analyte can be performed. Analyte receptors can be either highly selective or have lesser selectivity. Reproducible, concentration-dependent Raman spectroscopic analyses can be performed using flow-through cells incorporating passivated substrates. By using receptors having low selectivity, different analytes can be detected simultaneously. Flow cells are provided that permit rapid, and/or continuous monitoring of samples, thereby permitting automated sample analysis.
L'invention se rapporte à des dispositifs, des compositions et des procédés de détection quantitative d'analytes dans des solutions complexes grâce à la spectrométrie Raman. Des agents de passivation associés aux surfaces amplificatrices peuvent diminuer des interactions directes non spécifiques entre des analytes et la surface amplificatrice. La diminution des interactions directes entre des analytes et des surfaces amplificatrices permet de procéder à une détection des analytes relativement plus sélective. Des récepteurs d'analytes peuvent présenter une sélectivité élevée ou une sélectivité faible. Des analyses spectroscopiques Raman qui dépendent de la concentration et sont reproductibles peuvent être effectuées au moyen de cellules à flux continu qui contiennent des substrats passivés. L'utilisation de récepteurs présentant une faible sélectivité permet de détecter simultanément différents analytes. Des cuves de circulation servent au contrôle rapide et/ou continu des échantillons, ce qui permet des analyses automatiques d'échantillons |
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L'invention se rapporte à des dispositifs, des compositions et des procédés de détection quantitative d'analytes dans des solutions complexes grâce à la spectrométrie Raman. Des agents de passivation associés aux surfaces amplificatrices peuvent diminuer des interactions directes non spécifiques entre des analytes et la surface amplificatrice. La diminution des interactions directes entre des analytes et des surfaces amplificatrices permet de procéder à une détection des analytes relativement plus sélective. Des récepteurs d'analytes peuvent présenter une sélectivité élevée ou une sélectivité faible. Des analyses spectroscopiques Raman qui dépendent de la concentration et sont reproductibles peuvent être effectuées au moyen de cellules à flux continu qui contiennent des substrats passivés. L'utilisation de récepteurs présentant une faible sélectivité permet de détecter simultanément différents analytes. Des cuves de circulation servent au contrôle rapide et/ou continu des échantillons, ce qui permet des analyses automatiques d'échantillons</description><edition>7</edition><language>eng ; fre</language><subject>BLASTING ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; HEAT EXCHANGE IN GENERAL ; HEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS,IN WHICH THE HEAT-EXCHANGE MEDIA DO NOT COME INTO DIRECT CONTACT ; HEATING ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; LIGHTING ; MANUFACTURE OR TREATMENT THEREOF ; MEASURING ; MECHANICAL ENGINEERING ; NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS ; NANOTECHNOLOGY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PHYSICS ; RANGES ; SOLAR HEAT COLLECTORS ; SOLAR HEAT SYSTEMS ; TESTING ; THEIR RELEVANT APPARATUS ; TRANSPORTING ; VENTILATING ; WEAPONS</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030220&DB=EPODOC&CC=WO&NR=03014697A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030220&DB=EPODOC&CC=WO&NR=03014697A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KREIMER, DAVID, I</creatorcontrib><creatorcontrib>GINZBURG, LEV, V</creatorcontrib><creatorcontrib>YEVIN, OLEG, A</creatorcontrib><title>AMPLIFICATION OF ANALYTE DETECTION WITH PASSIVATED ENHANCING SURFACES HAVING RECEPTORS</title><description>This invention comprises devices, compositions and methods for quantitative detecting analytes in complex solutions by Raman spectroscopy. Passivating agents associated with enhancing surfaces can decrease direct, non-specific interaction between analytes and the enhancing surface. By decreasing direct interaction between analytes and enhancing surfaces, relatively more selective detection of the analyte can be performed. Analyte receptors can be either highly selective or have lesser selectivity. Reproducible, concentration-dependent Raman spectroscopic analyses can be performed using flow-through cells incorporating passivated substrates. By using receptors having low selectivity, different analytes can be detected simultaneously. Flow cells are provided that permit rapid, and/or continuous monitoring of samples, thereby permitting automated sample analysis.
L'invention se rapporte à des dispositifs, des compositions et des procédés de détection quantitative d'analytes dans des solutions complexes grâce à la spectrométrie Raman. Des agents de passivation associés aux surfaces amplificatrices peuvent diminuer des interactions directes non spécifiques entre des analytes et la surface amplificatrice. La diminution des interactions directes entre des analytes et des surfaces amplificatrices permet de procéder à une détection des analytes relativement plus sélective. Des récepteurs d'analytes peuvent présenter une sélectivité élevée ou une sélectivité faible. Des analyses spectroscopiques Raman qui dépendent de la concentration et sont reproductibles peuvent être effectuées au moyen de cellules à flux continu qui contiennent des substrats passivés. L'utilisation de récepteurs présentant une faible sélectivité permet de détecter simultanément différents analytes. 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Passivating agents associated with enhancing surfaces can decrease direct, non-specific interaction between analytes and the enhancing surface. By decreasing direct interaction between analytes and enhancing surfaces, relatively more selective detection of the analyte can be performed. Analyte receptors can be either highly selective or have lesser selectivity. Reproducible, concentration-dependent Raman spectroscopic analyses can be performed using flow-through cells incorporating passivated substrates. By using receptors having low selectivity, different analytes can be detected simultaneously. Flow cells are provided that permit rapid, and/or continuous monitoring of samples, thereby permitting automated sample analysis.
L'invention se rapporte à des dispositifs, des compositions et des procédés de détection quantitative d'analytes dans des solutions complexes grâce à la spectrométrie Raman. Des agents de passivation associés aux surfaces amplificatrices peuvent diminuer des interactions directes non spécifiques entre des analytes et la surface amplificatrice. La diminution des interactions directes entre des analytes et des surfaces amplificatrices permet de procéder à une détection des analytes relativement plus sélective. Des récepteurs d'analytes peuvent présenter une sélectivité élevée ou une sélectivité faible. Des analyses spectroscopiques Raman qui dépendent de la concentration et sont reproductibles peuvent être effectuées au moyen de cellules à flux continu qui contiennent des substrats passivés. L'utilisation de récepteurs présentant une faible sélectivité permet de détecter simultanément différents analytes. Des cuves de circulation servent au contrôle rapide et/ou continu des échantillons, ce qui permet des analyses automatiques d'échantillons</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BLASTING CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY HEAT EXCHANGE IN GENERAL HEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS,IN WHICH THE HEAT-EXCHANGE MEDIA DO NOT COME INTO DIRECT CONTACT HEATING INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIGHTING MANUFACTURE OR TREATMENT THEREOF MEASURING MECHANICAL ENGINEERING NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS NANOTECHNOLOGY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS RANGES SOLAR HEAT COLLECTORS SOLAR HEAT SYSTEMS TESTING THEIR RELEVANT APPARATUS TRANSPORTING VENTILATING WEAPONS |
| title | AMPLIFICATION OF ANALYTE DETECTION WITH PASSIVATED ENHANCING SURFACES HAVING RECEPTORS |
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