P53 BINDING PROTEIN-RELATED PROTEIN IN CARDIOMYOPATHY

The present invention is directed to a mouse model of dilated cardiomyopathy in which animals are deficient in the expression of a gene encoding a p53 binding protein-related protein (PRP). The invention also encompasses the mouse PRP gene and protein themselves as well as counterparts found in the...

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Bibliographische Detailangaben
Hauptverfasser:	HERRON, BRUCE, BEIER, DAVID, R, RAO, CHERIE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is directed to a mouse model of dilated cardiomyopathy in which animals are deficient in the expression of a gene encoding a p53 binding protein-related protein (PRP). The invention also encompasses the mouse PRP gene and protein themselves as well as counterparts found in the human. The various genes and proteins can be used in making transgenic animals and in assays designed to determine the likelihood of an individual developing cardiomyopathy. L'invention porte sur un modèle murin de cardiomyopathie dilatée dans lequel les animaux présentent une déficience dans l'expression d'un gène codant pour une protéine parente de protéine (PRP) se fixant à la p53. L'invention porte également sur le gène et la protéine PRP eux-mêmes et sur leurs contreparties trouvées chez l'homme. Ces divers gènes et protéines peuvent servir à produire des animaux transgéniques et dans à des essais visant à déterminer la propension d'un individu à la cardiomyopathie.