COMPOUNDS AND METHODS FOR PREPARING METHANESULFONAMIDES
A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl ]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | GOBLE, MICHAEL, PAUL KALTHOD, VIKRAM, GURUDATH MATISON, MICHAEL, E MCMILLAN, MOSES, W HERRINTON, PAUL, M MACKEY, SONJA, SUZANNE WU, HAIFENG |
| description | A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl ]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanes ulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.
A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.
La présente invention concerne un procédé permettant d'élaborer le sel (S)-(-)-N-[4-[4-[éthyle(6-fluoro-6-méthyleheptyl)amino]-1-hydroxy]phényle]méthanesulfonamide-hémifumarate. Ce procédé implique de faire réagir du N-[4[(2S)-tétrahydro-5-hydroxy-2-furanyle]phényle]méthanesulfonamide (IIa) avec du fluoroamine (III) en présence de triacétoxyborohydrure et de l'acétate d'éthyle de façon à donner du [4-[-4-[éthyle(6-fluoro-6-méthyleheptyle)amino]-1-hydroxy]phényle]méthanesulfonamide (I), puis de convertir ce dernier (I) pour donner le sel hémifumarate (Ia). L'invention concerne également un procédé permettant l'élaboration du méthanesulfonamide (IIa) ainsi que des intermédiaires (IIa à IId). |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO02098845A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO02098845A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO02098845A13</originalsourceid><addsrcrecordid>eNrjZDB39vcN8A_1cwlWcPRzUfB1DfHwB7Ld_IMUAoJcAxyDPP3cwaKOfq7BoT5u_n6Ovp4ursE8DKxpiTnFqbxQmptB0c01xNlDN7UgPz61uCAxOTUvtSQ-3N_AyMDSwsLE1NHQmBg1AF9nKKw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>COMPOUNDS AND METHODS FOR PREPARING METHANESULFONAMIDES</title><source>esp@cenet</source><creator>GOBLE, MICHAEL, PAUL ; KALTHOD, VIKRAM, GURUDATH ; MATISON, MICHAEL, E ; MCMILLAN, MOSES, W ; HERRINTON, PAUL, M ; MACKEY, SONJA, SUZANNE ; WU, HAIFENG</creator><creatorcontrib>GOBLE, MICHAEL, PAUL ; KALTHOD, VIKRAM, GURUDATH ; MATISON, MICHAEL, E ; MCMILLAN, MOSES, W ; HERRINTON, PAUL, M ; MACKEY, SONJA, SUZANNE ; WU, HAIFENG</creatorcontrib><description>A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl ]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanes ulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.
A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.
La présente invention concerne un procédé permettant d'élaborer le sel (S)-(-)-N-[4-[4-[éthyle(6-fluoro-6-méthyleheptyl)amino]-1-hydroxy]phényle]méthanesulfonamide-hémifumarate. Ce procédé implique de faire réagir du N-[4[(2S)-tétrahydro-5-hydroxy-2-furanyle]phényle]méthanesulfonamide (IIa) avec du fluoroamine (III) en présence de triacétoxyborohydrure et de l'acétate d'éthyle de façon à donner du [4-[-4-[éthyle(6-fluoro-6-méthyleheptyle)amino]-1-hydroxy]phényle]méthanesulfonamide (I), puis de convertir ce dernier (I) pour donner le sel hémifumarate (Ia). L'invention concerne également un procédé permettant l'élaboration du méthanesulfonamide (IIa) ainsi que des intermédiaires (IIa à IId).</description><edition>7</edition><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20021212&DB=EPODOC&CC=WO&NR=02098845A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20021212&DB=EPODOC&CC=WO&NR=02098845A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GOBLE, MICHAEL, PAUL</creatorcontrib><creatorcontrib>KALTHOD, VIKRAM, GURUDATH</creatorcontrib><creatorcontrib>MATISON, MICHAEL, E</creatorcontrib><creatorcontrib>MCMILLAN, MOSES, W</creatorcontrib><creatorcontrib>HERRINTON, PAUL, M</creatorcontrib><creatorcontrib>MACKEY, SONJA, SUZANNE</creatorcontrib><creatorcontrib>WU, HAIFENG</creatorcontrib><title>COMPOUNDS AND METHODS FOR PREPARING METHANESULFONAMIDES</title><description>A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl ]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanes ulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.
A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.
La présente invention concerne un procédé permettant d'élaborer le sel (S)-(-)-N-[4-[4-[éthyle(6-fluoro-6-méthyleheptyl)amino]-1-hydroxy]phényle]méthanesulfonamide-hémifumarate. Ce procédé implique de faire réagir du N-[4[(2S)-tétrahydro-5-hydroxy-2-furanyle]phényle]méthanesulfonamide (IIa) avec du fluoroamine (III) en présence de triacétoxyborohydrure et de l'acétate d'éthyle de façon à donner du [4-[-4-[éthyle(6-fluoro-6-méthyleheptyle)amino]-1-hydroxy]phényle]méthanesulfonamide (I), puis de convertir ce dernier (I) pour donner le sel hémifumarate (Ia). L'invention concerne également un procédé permettant l'élaboration du méthanesulfonamide (IIa) ainsi que des intermédiaires (IIa à IId).</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB39vcN8A_1cwlWcPRzUfB1DfHwB7Ld_IMUAoJcAxyDPP3cwaKOfq7BoT5u_n6Ovp4ursE8DKxpiTnFqbxQmptB0c01xNlDN7UgPz61uCAxOTUvtSQ-3N_AyMDSwsLE1NHQmBg1AF9nKKw</recordid><startdate>20021212</startdate><enddate>20021212</enddate><creator>GOBLE, MICHAEL, PAUL</creator><creator>KALTHOD, VIKRAM, GURUDATH</creator><creator>MATISON, MICHAEL, E</creator><creator>MCMILLAN, MOSES, W</creator><creator>HERRINTON, PAUL, M</creator><creator>MACKEY, SONJA, SUZANNE</creator><creator>WU, HAIFENG</creator><scope>EVB</scope></search><sort><creationdate>20021212</creationdate><title>COMPOUNDS AND METHODS FOR PREPARING METHANESULFONAMIDES</title><author>GOBLE, MICHAEL, PAUL ; KALTHOD, VIKRAM, GURUDATH ; MATISON, MICHAEL, E ; MCMILLAN, MOSES, W ; HERRINTON, PAUL, M ; MACKEY, SONJA, SUZANNE ; WU, HAIFENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO02098845A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2002</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>GOBLE, MICHAEL, PAUL</creatorcontrib><creatorcontrib>KALTHOD, VIKRAM, GURUDATH</creatorcontrib><creatorcontrib>MATISON, MICHAEL, E</creatorcontrib><creatorcontrib>MCMILLAN, MOSES, W</creatorcontrib><creatorcontrib>HERRINTON, PAUL, M</creatorcontrib><creatorcontrib>MACKEY, SONJA, SUZANNE</creatorcontrib><creatorcontrib>WU, HAIFENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GOBLE, MICHAEL, PAUL</au><au>KALTHOD, VIKRAM, GURUDATH</au><au>MATISON, MICHAEL, E</au><au>MCMILLAN, MOSES, W</au><au>HERRINTON, PAUL, M</au><au>MACKEY, SONJA, SUZANNE</au><au>WU, HAIFENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOUNDS AND METHODS FOR PREPARING METHANESULFONAMIDES</title><date>2002-12-12</date><risdate>2002</risdate><abstract>A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl ]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanes ulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.
A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.
La présente invention concerne un procédé permettant d'élaborer le sel (S)-(-)-N-[4-[4-[éthyle(6-fluoro-6-méthyleheptyl)amino]-1-hydroxy]phényle]méthanesulfonamide-hémifumarate. Ce procédé implique de faire réagir du N-[4[(2S)-tétrahydro-5-hydroxy-2-furanyle]phényle]méthanesulfonamide (IIa) avec du fluoroamine (III) en présence de triacétoxyborohydrure et de l'acétate d'éthyle de façon à donner du [4-[-4-[éthyle(6-fluoro-6-méthyleheptyle)amino]-1-hydroxy]phényle]méthanesulfonamide (I), puis de convertir ce dernier (I) pour donner le sel hémifumarate (Ia). L'invention concerne également un procédé permettant l'élaboration du méthanesulfonamide (IIa) ainsi que des intermédiaires (IIa à IId).</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO02098845A1 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | COMPOUNDS AND METHODS FOR PREPARING METHANESULFONAMIDES |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T21%3A40%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=GOBLE,%20MICHAEL,%20PAUL&rft.date=2002-12-12&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO02098845A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |