METHODS AND REAGENTS FOR CELL TRANSPLANTATION
The invention features methods for producing cells for transplantation into myocardial tissue of a mammal (e.g., a human). The method includes the steps of (a) providing a population of bone marrow stem cells; (b) culturing the cells under conditions that induce the cells to become cardiomyogenic ce...
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| creator | CROISSANT, JEFFREY, D LIU, GUIZHEN LEE, IKE, W HAMPE, JAMES |
| description | The invention features methods for producing cells for transplantation into myocardial tissue of a mammal (e.g., a human). The method includes the steps of (a) providing a population of bone marrow stem cells; (b) culturing the cells under conditions that induce the cells to become cardiomyogenic cells; (c) monitoring the state of differentiation of the cells of step (b); and (d) collecting the cells of step (b) when at least about 10% and as many as 100% of the cells are cardiomyogenic cells. The bone marrow stem cells can be, for example, human bone marrow stem cells. In one embodiment, the method includes the step of transplanting the differentiated stem cells into a mammal (e.g., a human).
L'invention concerne des méthodes permettant de produire des cellules destinées à une transplantation dans le tissu myocardique d'un mammifère (par exemple, un humain). Ladite méthode consiste a) à fournir une population de cellules souches de moelle osseuse; b) à cultiver ces cellules dans des conditions induisant la différenciation desdites cellules en cellules cardiomyogéniques; c) à surveiller la phase de différentiation des cellules de l'étape (b); et à d) collecter les cellules de l'étape b) lorsqu'au moins 10% à 100% des cellules sont des cellules cardiomyogéniques. Les cellules souches de moelle osseuse peuvent être, par exemple, des cellules souches de moelle osseuse humaine. Dans un mode de réalisation, cette méthode consiste à transplanter les cellules souches différentiées dans un mammifère (par exemple, un humain). |
| format | Patent |
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L'invention concerne des méthodes permettant de produire des cellules destinées à une transplantation dans le tissu myocardique d'un mammifère (par exemple, un humain). Ladite méthode consiste a) à fournir une population de cellules souches de moelle osseuse; b) à cultiver ces cellules dans des conditions induisant la différenciation desdites cellules en cellules cardiomyogéniques; c) à surveiller la phase de différentiation des cellules de l'étape (b); et à d) collecter les cellules de l'étape b) lorsqu'au moins 10% à 100% des cellules sont des cellules cardiomyogéniques. Les cellules souches de moelle osseuse peuvent être, par exemple, des cellules souches de moelle osseuse humaine. Dans un mode de réalisation, cette méthode consiste à transplanter les cellules souches différentiées dans un mammifère (par exemple, un humain).</description><edition>7</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030227&DB=EPODOC&CC=WO&NR=02083864A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030227&DB=EPODOC&CC=WO&NR=02083864A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CROISSANT, JEFFREY, D</creatorcontrib><creatorcontrib>LIU, GUIZHEN</creatorcontrib><creatorcontrib>LEE, IKE, W</creatorcontrib><creatorcontrib>HAMPE, JAMES</creatorcontrib><title>METHODS AND REAGENTS FOR CELL TRANSPLANTATION</title><description>The invention features methods for producing cells for transplantation into myocardial tissue of a mammal (e.g., a human). The method includes the steps of (a) providing a population of bone marrow stem cells; (b) culturing the cells under conditions that induce the cells to become cardiomyogenic cells; (c) monitoring the state of differentiation of the cells of step (b); and (d) collecting the cells of step (b) when at least about 10% and as many as 100% of the cells are cardiomyogenic cells. The bone marrow stem cells can be, for example, human bone marrow stem cells. In one embodiment, the method includes the step of transplanting the differentiated stem cells into a mammal (e.g., a human).
L'invention concerne des méthodes permettant de produire des cellules destinées à une transplantation dans le tissu myocardique d'un mammifère (par exemple, un humain). Ladite méthode consiste a) à fournir une population de cellules souches de moelle osseuse; b) à cultiver ces cellules dans des conditions induisant la différenciation desdites cellules en cellules cardiomyogéniques; c) à surveiller la phase de différentiation des cellules de l'étape (b); et à d) collecter les cellules de l'étape b) lorsqu'au moins 10% à 100% des cellules sont des cellules cardiomyogéniques. Les cellules souches de moelle osseuse peuvent être, par exemple, des cellules souches de moelle osseuse humaine. Dans un mode de réalisation, cette méthode consiste à transplanter les cellules souches différentiées dans un mammifère (par exemple, un humain).</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND1dQ3x8HcJVnD0c1EIcnV0d_ULCVZw8w9ScHb18VEICXL0Cw7wcfQLcQzx9PfjYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXx4f4GRgYWxhZmJo7GxsSoAQDCIyWr</recordid><startdate>20030227</startdate><enddate>20030227</enddate><creator>CROISSANT, JEFFREY, D</creator><creator>LIU, GUIZHEN</creator><creator>LEE, IKE, W</creator><creator>HAMPE, JAMES</creator><scope>EVB</scope></search><sort><creationdate>20030227</creationdate><title>METHODS AND REAGENTS FOR CELL TRANSPLANTATION</title><author>CROISSANT, JEFFREY, D ; LIU, GUIZHEN ; LEE, IKE, W ; HAMPE, JAMES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO02083864A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2003</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CROISSANT, JEFFREY, D</creatorcontrib><creatorcontrib>LIU, GUIZHEN</creatorcontrib><creatorcontrib>LEE, IKE, W</creatorcontrib><creatorcontrib>HAMPE, JAMES</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CROISSANT, JEFFREY, D</au><au>LIU, GUIZHEN</au><au>LEE, IKE, W</au><au>HAMPE, JAMES</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS AND REAGENTS FOR CELL TRANSPLANTATION</title><date>2003-02-27</date><risdate>2003</risdate><abstract>The invention features methods for producing cells for transplantation into myocardial tissue of a mammal (e.g., a human). The method includes the steps of (a) providing a population of bone marrow stem cells; (b) culturing the cells under conditions that induce the cells to become cardiomyogenic cells; (c) monitoring the state of differentiation of the cells of step (b); and (d) collecting the cells of step (b) when at least about 10% and as many as 100% of the cells are cardiomyogenic cells. The bone marrow stem cells can be, for example, human bone marrow stem cells. In one embodiment, the method includes the step of transplanting the differentiated stem cells into a mammal (e.g., a human).
L'invention concerne des méthodes permettant de produire des cellules destinées à une transplantation dans le tissu myocardique d'un mammifère (par exemple, un humain). Ladite méthode consiste a) à fournir une population de cellules souches de moelle osseuse; b) à cultiver ces cellules dans des conditions induisant la différenciation desdites cellules en cellules cardiomyogéniques; c) à surveiller la phase de différentiation des cellules de l'étape (b); et à d) collecter les cellules de l'étape b) lorsqu'au moins 10% à 100% des cellules sont des cellules cardiomyogéniques. Les cellules souches de moelle osseuse peuvent être, par exemple, des cellules souches de moelle osseuse humaine. Dans un mode de réalisation, cette méthode consiste à transplanter les cellules souches différentiées dans un mammifère (par exemple, un humain).</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ENZYMOLOGY HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | METHODS AND REAGENTS FOR CELL TRANSPLANTATION |
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