TRANSGENIC ANIMALS RESISTANT TO TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES
The invention provides modified prion-encoding genes for the creation of transgenic bovine and cervid animals resistant to transmissible spongiform encephalopathies including bovine spongiform encephalopathy (BSE). The transgenic animals homozygous for the mutant genes continue to express a function...
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| creator | DUNNE, PATRICK, W PIEDRAHITA, JORGE |
| description | The invention provides modified prion-encoding genes for the creation of transgenic bovine and cervid animals resistant to transmissible spongiform encephalopathies including bovine spongiform encephalopathy (BSE). The transgenic animals homozygous for the mutant genes continue to express a functional copy of the prion-encoding gene, thereby not interfering with the normal role of the polypeptide and effectively decreasing tendency for alteration of sleep-wake cycles.
L'invention concerne des gènes modifiés codant pour les prions, permettant la création d'animaux bovins et cervidés transgéniques résistant aux encéphalopathies spongiformes transmissibles, dont l'encéphalopathie spongiforme bovine (BSE). Les animaux transgéniques de l'invention homozygotes pour les gènes mutants continuent à exprimer une copie fonctionnelle du gène codant pour les prions, et n'interfèrent donc pas avec le rôle normal du polypeptide et réduisent efficacement la tendance à la modification des cycles de sommeil-éveil. |
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L'invention concerne des gènes modifiés codant pour les prions, permettant la création d'animaux bovins et cervidés transgéniques résistant aux encéphalopathies spongiformes transmissibles, dont l'encéphalopathie spongiforme bovine (BSE). Les animaux transgéniques de l'invention homozygotes pour les gènes mutants continuent à exprimer une copie fonctionnelle du gène codant pour les prions, et n'interfèrent donc pas avec le rôle normal du polypeptide et réduisent efficacement la tendance à la modification des cycles de sommeil-éveil.</description><edition>7</edition><language>eng ; fre</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BEER ; BIOCHEMISTRY ; CARE OF BIRDS, FISHES, INSECTS ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NEW BREEDS OF ANIMALS ; ORGANIC CHEMISTRY ; PEPTIDES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR ; SPIRITS ; TRAPPING ; VINEGAR ; WINE</subject><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20021010&DB=EPODOC&CC=WO&NR=02079416A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20021010&DB=EPODOC&CC=WO&NR=02079416A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DUNNE, PATRICK, W</creatorcontrib><creatorcontrib>PIEDRAHITA, JORGE</creatorcontrib><title>TRANSGENIC ANIMALS RESISTANT TO TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES</title><description>The invention provides modified prion-encoding genes for the creation of transgenic bovine and cervid animals resistant to transmissible spongiform encephalopathies including bovine spongiform encephalopathy (BSE). The transgenic animals homozygous for the mutant genes continue to express a functional copy of the prion-encoding gene, thereby not interfering with the normal role of the polypeptide and effectively decreasing tendency for alteration of sleep-wake cycles.
L'invention concerne des gènes modifiés codant pour les prions, permettant la création d'animaux bovins et cervidés transgéniques résistant aux encéphalopathies spongiformes transmissibles, dont l'encéphalopathie spongiforme bovine (BSE). Les animaux transgéniques de l'invention homozygotes pour les gènes mutants continuent à exprimer une copie fonctionnelle du gène codant pour les prions, et n'interfèrent donc pas avec le rôle normal du polypeptide et réduisent efficacement la tendance à la modification des cycles de sommeil-éveil.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CARE OF BIRDS, FISHES, INSECTS</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NEW BREEDS OF ANIMALS</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</subject><subject>SPIRITS</subject><subject>TRAPPING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAMCXL0C3Z39fN0VnD08_R19AlWCHIN9gwOcfQLUQjxVwDL-3oGB3s6-bgqBAf4-7l7uvkH-Sq4-jm7Bng4-vgHOIZ4eLoG8zCwpiXmFKfyQmluBkU31xBnD93Ugvz41OKCxOTUvNSS-HB_AyMDc0sTQzNHI2Ni1AAAhtct7A</recordid><startdate>20021010</startdate><enddate>20021010</enddate><creator>DUNNE, PATRICK, W</creator><creator>PIEDRAHITA, JORGE</creator><scope>EVB</scope></search><sort><creationdate>20021010</creationdate><title>TRANSGENIC ANIMALS RESISTANT TO TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES</title><author>DUNNE, PATRICK, W ; PIEDRAHITA, JORGE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO02079416A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2002</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CARE OF BIRDS, FISHES, INSECTS</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NEW BREEDS OF ANIMALS</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</topic><topic>SPIRITS</topic><topic>TRAPPING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>DUNNE, PATRICK, W</creatorcontrib><creatorcontrib>PIEDRAHITA, JORGE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DUNNE, PATRICK, W</au><au>PIEDRAHITA, JORGE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TRANSGENIC ANIMALS RESISTANT TO TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES</title><date>2002-10-10</date><risdate>2002</risdate><abstract>The invention provides modified prion-encoding genes for the creation of transgenic bovine and cervid animals resistant to transmissible spongiform encephalopathies including bovine spongiform encephalopathy (BSE). The transgenic animals homozygous for the mutant genes continue to express a functional copy of the prion-encoding gene, thereby not interfering with the normal role of the polypeptide and effectively decreasing tendency for alteration of sleep-wake cycles.
L'invention concerne des gènes modifiés codant pour les prions, permettant la création d'animaux bovins et cervidés transgéniques résistant aux encéphalopathies spongiformes transmissibles, dont l'encéphalopathie spongiforme bovine (BSE). Les animaux transgéniques de l'invention homozygotes pour les gènes mutants continuent à exprimer une copie fonctionnelle du gène codant pour les prions, et n'interfèrent donc pas avec le rôle normal du polypeptide et réduisent efficacement la tendance à la modification des cycles de sommeil-éveil.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TRAPPING VINEGAR WINE |
| title | TRANSGENIC ANIMALS RESISTANT TO TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES |
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