GENE DELIVERY FORMULATIONS AND METHODS FOR TREATMENT OF ISCHEMIC CONDITIONS

The present inventors have developed a novel approach for efficient delivery of angiogenic factors to the cardiac and peripheral vasculature that avoids problems with toxicity inherent to existing delivery technologies. Vectors carrying coding sequences for Del-1 or VEGF, or both, can be formulated...

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Hauptverfasser: NORDSTROM, JEFFREY, L, YOUNG, STEWART, COLEMAN, MICHAEL, E, THIESSE, MARY, L, WANG, JIJUN, MACLAUGHLIN, FIONA
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creator NORDSTROM, JEFFREY, L
YOUNG, STEWART
COLEMAN, MICHAEL, E
THIESSE, MARY, L
WANG, JIJUN
MACLAUGHLIN, FIONA
description The present inventors have developed a novel approach for efficient delivery of angiogenic factors to the cardiac and peripheral vasculature that avoids problems with toxicity inherent to existing delivery technologies. Vectors carrying coding sequences for Del-1 or VEGF, or both, can be formulated with poloxamers or other polymers for delivery into ischemic tissue and delivered to the heart by retrograde venous perfusion. La présente invention concerne une nouvelle approche pour une diffusion efficiente de facteurs angiogéniques dans le système vasculaire cardiaque et périphérique, qui évite les problèmes de toxicité inhérents aux techniques de diffusion existantes. Des vecteurs transportant des séquences de codage pour Del-1 et/ou VEGF peuvent être préparés avec des poloxamères ou autres polymères aux fins de diffusion dans un tissu ischémique, et diffusés dans le coeur par perfusion veineuse rétrograde.
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
title GENE DELIVERY FORMULATIONS AND METHODS FOR TREATMENT OF ISCHEMIC CONDITIONS
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