SOLID DOSAGE FORMS OF DIVALPROEX SODIUM
The present invention is directed to an aqueous process for granulating valproate compounds, in which the pH of the granulation solution is maintained at a pH of 5 or below. The invention is also directed to dosage forms in which the residual content of organic solvents is reduced to a level of 0.2w...
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| creator | ENGH, KEVIN, R SLADE, RUSSELL, T QIU, YIHONG FAITSCH, LYNN |
| description | The present invention is directed to an aqueous process for granulating valproate compounds, in which the pH of the granulation solution is maintained at a pH of 5 or below. The invention is also directed to dosage forms in which the residual content of organic solvents is reduced to a level of 0.2w/w% or less.
La présente invention concerne un procédé de granulation aqueuse de composés valproate, dans lequel le pH de la solution de granulation est maintenu à une valeur inférieure ou égale à 5. Cette invention concerne également des formes posologiques dans lesquelles la teneur en résidus de solvants organiques est réduite à un niveau égal ou inférieur à 0,2 % en poids. |
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La présente invention concerne un procédé de granulation aqueuse de composés valproate, dans lequel le pH de la solution de granulation est maintenu à une valeur inférieure ou égale à 5. Cette invention concerne également des formes posologiques dans lesquelles la teneur en résidus de solvants organiques est réduite à un niveau égal ou inférieur à 0,2 % en poids.</description><edition>7</edition><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020704&DB=EPODOC&CC=WO&NR=02051400A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020704&DB=EPODOC&CC=WO&NR=02051400A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ENGH, KEVIN, R</creatorcontrib><creatorcontrib>SLADE, RUSSELL, T</creatorcontrib><creatorcontrib>QIU, YIHONG</creatorcontrib><creatorcontrib>FAITSCH, LYNN</creatorcontrib><title>SOLID DOSAGE FORMS OF DIVALPROEX SODIUM</title><description>The present invention is directed to an aqueous process for granulating valproate compounds, in which the pH of the granulation solution is maintained at a pH of 5 or below. The invention is also directed to dosage forms in which the residual content of organic solvents is reduced to a level of 0.2w/w% or less.
La présente invention concerne un procédé de granulation aqueuse de composés valproate, dans lequel le pH de la solution de granulation est maintenu à une valeur inférieure ou égale à 5. Cette invention concerne également des formes posologiques dans lesquelles la teneur en résidus de solvants organiques est réduite à un niveau égal ou inférieur à 0,2 % en poids.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAP9vfxdFFw8Q92dHdVcPMP8g1W8HdTcPEMc_QJCPJ3jVAI9nfxDPXlYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXx4f4GRgamhiYGBo5GxsSoAQDg1SPN</recordid><startdate>20020704</startdate><enddate>20020704</enddate><creator>ENGH, KEVIN, R</creator><creator>SLADE, RUSSELL, T</creator><creator>QIU, YIHONG</creator><creator>FAITSCH, LYNN</creator><scope>EVB</scope></search><sort><creationdate>20020704</creationdate><title>SOLID DOSAGE FORMS OF DIVALPROEX SODIUM</title><author>ENGH, KEVIN, R ; SLADE, RUSSELL, T ; QIU, YIHONG ; FAITSCH, LYNN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO02051400A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2002</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>ENGH, KEVIN, R</creatorcontrib><creatorcontrib>SLADE, RUSSELL, T</creatorcontrib><creatorcontrib>QIU, YIHONG</creatorcontrib><creatorcontrib>FAITSCH, LYNN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ENGH, KEVIN, R</au><au>SLADE, RUSSELL, T</au><au>QIU, YIHONG</au><au>FAITSCH, LYNN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SOLID DOSAGE FORMS OF DIVALPROEX SODIUM</title><date>2002-07-04</date><risdate>2002</risdate><abstract>The present invention is directed to an aqueous process for granulating valproate compounds, in which the pH of the granulation solution is maintained at a pH of 5 or below. The invention is also directed to dosage forms in which the residual content of organic solvents is reduced to a level of 0.2w/w% or less.
La présente invention concerne un procédé de granulation aqueuse de composés valproate, dans lequel le pH de la solution de granulation est maintenu à une valeur inférieure ou égale à 5. Cette invention concerne également des formes posologiques dans lesquelles la teneur en résidus de solvants organiques est réduite à un niveau égal ou inférieur à 0,2 % en poids.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| title | SOLID DOSAGE FORMS OF DIVALPROEX SODIUM |
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