p-CRESOL SULFATE, A COMPONENT OF URINARY MYELIN BASIC PROTEIN-LIKE MATERIAL, AS A CORRELATE OF MULTIPLE SCLEROSIS STATUS
The present invention provides a method of determining the status of a multiple sclerosis patient, i.e., predicting the transition from a status of relapsing-remitting to a progressive phase of multiple sclerosis, comprising the step of measuring the amount of urinary p-cresol sulfate in the patient...
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| creator | KACHELHOFER, ROBERT, DAVID REDER, ANTHONY, THOMAS ZHAO, GUOJUN CAO, LIGONG JACKSON, PATRICIA, L LAYTON, BEVERLY, ANN MORRISION, WENDY, JEAN COWARD, LORI KIRK, MARION PATY, DONALD, WINSTON WHITAKER, JOHN, NICHOLAS BRADLEY, EDWIN, LUTHER, JR BURGARD, SHEILA, LOUGHRAN |
| description | The present invention provides a method of determining the status of a multiple sclerosis patient, i.e., predicting the transition from a status of relapsing-remitting to a progressive phase of multiple sclerosis, comprising the step of measuring the amount of urinary p-cresol sulfate in the patient. The present invention also provides a method of determining the amount of lesions and total lesion area of a multiple sclerosis patient, comprising the step of measuring the amount of urinary p-cresol sulfate in the patient. Further provided is a method of monitoring myelination in a developing child, comprising the step of: measuring the amount of p-cresol sulfate in the urine of said child.
La présente invention se rapporte à un procédé de détermination de l'état d'un patient atteint de sclérose en plaques, c'est à dire de prévision de la transition d'un état à périodes progressives et rémittentes à une phase progressive de la sclérose en plaques, ledit procédé consistant à mesurer la quantité de sulfate de p-crésol urinaire chez un patient. La présente invention se rapporte également à un procédé de détermination de la quantité de lésions et de la surface totale des lésions d'un patient atteint de sclérose en plaques, qui consiste à mesurer la quantité de sulfate de p-crésol urinaire chez le patient. Enfin, l'invention se rapporte à un procédé de surveillance de la myélinisation chez un enfant en développement, qui consiste à mesurer la quantité de sulfate de p-crésol dans l'urine dudit enfant. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO0125787A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO0125787A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO0125787A13</originalsourceid><addsrcrecordid>eNqNyzEKwkAQheE0FqLeYQ5gwCii7bpMcHCyG2Z2kVQhyFqJBmLh8Y3iAawe_Lxvmr363AqqZ9DIpQm4BAPWV7V36AL4EqKQM9JA1SCTg4NRslCLD0guZzohVCMTMjxS_WoR5LF9dBU5UM0IahnFKyloMCHqPJtcu9uQFr-dZVBisMc89Y82DX13Sff0bM9-Vay3u_3OFJs_Lm8ZJjmt</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>p-CRESOL SULFATE, A COMPONENT OF URINARY MYELIN BASIC PROTEIN-LIKE MATERIAL, AS A CORRELATE OF MULTIPLE SCLEROSIS STATUS</title><source>esp@cenet</source><creator>KACHELHOFER, ROBERT, DAVID ; REDER, ANTHONY, THOMAS ; ZHAO, GUOJUN ; CAO, LIGONG ; JACKSON, PATRICIA, L ; LAYTON, BEVERLY, ANN ; MORRISION, WENDY, JEAN ; COWARD, LORI ; KIRK, MARION ; PATY, DONALD, WINSTON ; WHITAKER, JOHN, NICHOLAS ; BRADLEY, EDWIN, LUTHER, JR ; BURGARD, SHEILA, LOUGHRAN</creator><creatorcontrib>KACHELHOFER, ROBERT, DAVID ; REDER, ANTHONY, THOMAS ; ZHAO, GUOJUN ; CAO, LIGONG ; JACKSON, PATRICIA, L ; LAYTON, BEVERLY, ANN ; MORRISION, WENDY, JEAN ; COWARD, LORI ; KIRK, MARION ; PATY, DONALD, WINSTON ; WHITAKER, JOHN, NICHOLAS ; BRADLEY, EDWIN, LUTHER, JR ; BURGARD, SHEILA, LOUGHRAN</creatorcontrib><description>The present invention provides a method of determining the status of a multiple sclerosis patient, i.e., predicting the transition from a status of relapsing-remitting to a progressive phase of multiple sclerosis, comprising the step of measuring the amount of urinary p-cresol sulfate in the patient. The present invention also provides a method of determining the amount of lesions and total lesion area of a multiple sclerosis patient, comprising the step of measuring the amount of urinary p-cresol sulfate in the patient. Further provided is a method of monitoring myelination in a developing child, comprising the step of: measuring the amount of p-cresol sulfate in the urine of said child.
La présente invention se rapporte à un procédé de détermination de l'état d'un patient atteint de sclérose en plaques, c'est à dire de prévision de la transition d'un état à périodes progressives et rémittentes à une phase progressive de la sclérose en plaques, ledit procédé consistant à mesurer la quantité de sulfate de p-crésol urinaire chez un patient. La présente invention se rapporte également à un procédé de détermination de la quantité de lésions et de la surface totale des lésions d'un patient atteint de sclérose en plaques, qui consiste à mesurer la quantité de sulfate de p-crésol urinaire chez le patient. Enfin, l'invention se rapporte à un procédé de surveillance de la myélinisation chez un enfant en développement, qui consiste à mesurer la quantité de sulfate de p-crésol dans l'urine dudit enfant.</description><edition>7</edition><language>eng ; fre</language><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; PHYSICS ; TESTING</subject><creationdate>2001</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010412&DB=EPODOC&CC=WO&NR=0125787A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010412&DB=EPODOC&CC=WO&NR=0125787A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KACHELHOFER, ROBERT, DAVID</creatorcontrib><creatorcontrib>REDER, ANTHONY, THOMAS</creatorcontrib><creatorcontrib>ZHAO, GUOJUN</creatorcontrib><creatorcontrib>CAO, LIGONG</creatorcontrib><creatorcontrib>JACKSON, PATRICIA, L</creatorcontrib><creatorcontrib>LAYTON, BEVERLY, ANN</creatorcontrib><creatorcontrib>MORRISION, WENDY, JEAN</creatorcontrib><creatorcontrib>COWARD, LORI</creatorcontrib><creatorcontrib>KIRK, MARION</creatorcontrib><creatorcontrib>PATY, DONALD, WINSTON</creatorcontrib><creatorcontrib>WHITAKER, JOHN, NICHOLAS</creatorcontrib><creatorcontrib>BRADLEY, EDWIN, LUTHER, JR</creatorcontrib><creatorcontrib>BURGARD, SHEILA, LOUGHRAN</creatorcontrib><title>p-CRESOL SULFATE, A COMPONENT OF URINARY MYELIN BASIC PROTEIN-LIKE MATERIAL, AS A CORRELATE OF MULTIPLE SCLEROSIS STATUS</title><description>The present invention provides a method of determining the status of a multiple sclerosis patient, i.e., predicting the transition from a status of relapsing-remitting to a progressive phase of multiple sclerosis, comprising the step of measuring the amount of urinary p-cresol sulfate in the patient. The present invention also provides a method of determining the amount of lesions and total lesion area of a multiple sclerosis patient, comprising the step of measuring the amount of urinary p-cresol sulfate in the patient. Further provided is a method of monitoring myelination in a developing child, comprising the step of: measuring the amount of p-cresol sulfate in the urine of said child.
La présente invention se rapporte à un procédé de détermination de l'état d'un patient atteint de sclérose en plaques, c'est à dire de prévision de la transition d'un état à périodes progressives et rémittentes à une phase progressive de la sclérose en plaques, ledit procédé consistant à mesurer la quantité de sulfate de p-crésol urinaire chez un patient. La présente invention se rapporte également à un procédé de détermination de la quantité de lésions et de la surface totale des lésions d'un patient atteint de sclérose en plaques, qui consiste à mesurer la quantité de sulfate de p-crésol urinaire chez le patient. Enfin, l'invention se rapporte à un procédé de surveillance de la myélinisation chez un enfant en développement, qui consiste à mesurer la quantité de sulfate de p-crésol dans l'urine dudit enfant.</description><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>PHYSICS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2001</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyzEKwkAQheE0FqLeYQ5gwCii7bpMcHCyG2Z2kVQhyFqJBmLh8Y3iAawe_Lxvmr363AqqZ9DIpQm4BAPWV7V36AL4EqKQM9JA1SCTg4NRslCLD0guZzohVCMTMjxS_WoR5LF9dBU5UM0IahnFKyloMCHqPJtcu9uQFr-dZVBisMc89Y82DX13Sff0bM9-Vay3u_3OFJs_Lm8ZJjmt</recordid><startdate>20010412</startdate><enddate>20010412</enddate><creator>KACHELHOFER, ROBERT, DAVID</creator><creator>REDER, ANTHONY, THOMAS</creator><creator>ZHAO, GUOJUN</creator><creator>CAO, LIGONG</creator><creator>JACKSON, PATRICIA, L</creator><creator>LAYTON, BEVERLY, ANN</creator><creator>MORRISION, WENDY, JEAN</creator><creator>COWARD, LORI</creator><creator>KIRK, MARION</creator><creator>PATY, DONALD, WINSTON</creator><creator>WHITAKER, JOHN, NICHOLAS</creator><creator>BRADLEY, EDWIN, LUTHER, JR</creator><creator>BURGARD, SHEILA, LOUGHRAN</creator><scope>EVB</scope></search><sort><creationdate>20010412</creationdate><title>p-CRESOL SULFATE, A COMPONENT OF URINARY MYELIN BASIC PROTEIN-LIKE MATERIAL, AS A CORRELATE OF MULTIPLE SCLEROSIS STATUS</title><author>KACHELHOFER, ROBERT, DAVID ; REDER, ANTHONY, THOMAS ; ZHAO, GUOJUN ; CAO, LIGONG ; JACKSON, PATRICIA, L ; LAYTON, BEVERLY, ANN ; MORRISION, WENDY, JEAN ; COWARD, LORI ; KIRK, MARION ; PATY, DONALD, WINSTON ; WHITAKER, JOHN, NICHOLAS ; BRADLEY, EDWIN, LUTHER, JR ; BURGARD, SHEILA, LOUGHRAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO0125787A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2001</creationdate><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>PHYSICS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>KACHELHOFER, ROBERT, DAVID</creatorcontrib><creatorcontrib>REDER, ANTHONY, THOMAS</creatorcontrib><creatorcontrib>ZHAO, GUOJUN</creatorcontrib><creatorcontrib>CAO, LIGONG</creatorcontrib><creatorcontrib>JACKSON, PATRICIA, L</creatorcontrib><creatorcontrib>LAYTON, BEVERLY, ANN</creatorcontrib><creatorcontrib>MORRISION, WENDY, JEAN</creatorcontrib><creatorcontrib>COWARD, LORI</creatorcontrib><creatorcontrib>KIRK, MARION</creatorcontrib><creatorcontrib>PATY, DONALD, WINSTON</creatorcontrib><creatorcontrib>WHITAKER, JOHN, NICHOLAS</creatorcontrib><creatorcontrib>BRADLEY, EDWIN, LUTHER, JR</creatorcontrib><creatorcontrib>BURGARD, SHEILA, LOUGHRAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KACHELHOFER, ROBERT, DAVID</au><au>REDER, ANTHONY, THOMAS</au><au>ZHAO, GUOJUN</au><au>CAO, LIGONG</au><au>JACKSON, PATRICIA, L</au><au>LAYTON, BEVERLY, ANN</au><au>MORRISION, WENDY, JEAN</au><au>COWARD, LORI</au><au>KIRK, MARION</au><au>PATY, DONALD, WINSTON</au><au>WHITAKER, JOHN, NICHOLAS</au><au>BRADLEY, EDWIN, LUTHER, JR</au><au>BURGARD, SHEILA, LOUGHRAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>p-CRESOL SULFATE, A COMPONENT OF URINARY MYELIN BASIC PROTEIN-LIKE MATERIAL, AS A CORRELATE OF MULTIPLE SCLEROSIS STATUS</title><date>2001-04-12</date><risdate>2001</risdate><abstract>The present invention provides a method of determining the status of a multiple sclerosis patient, i.e., predicting the transition from a status of relapsing-remitting to a progressive phase of multiple sclerosis, comprising the step of measuring the amount of urinary p-cresol sulfate in the patient. The present invention also provides a method of determining the amount of lesions and total lesion area of a multiple sclerosis patient, comprising the step of measuring the amount of urinary p-cresol sulfate in the patient. Further provided is a method of monitoring myelination in a developing child, comprising the step of: measuring the amount of p-cresol sulfate in the urine of said child.
La présente invention se rapporte à un procédé de détermination de l'état d'un patient atteint de sclérose en plaques, c'est à dire de prévision de la transition d'un état à périodes progressives et rémittentes à une phase progressive de la sclérose en plaques, ledit procédé consistant à mesurer la quantité de sulfate de p-crésol urinaire chez un patient. La présente invention se rapporte également à un procédé de détermination de la quantité de lésions et de la surface totale des lésions d'un patient atteint de sclérose en plaques, qui consiste à mesurer la quantité de sulfate de p-crésol urinaire chez le patient. Enfin, l'invention se rapporte à un procédé de surveillance de la myélinisation chez un enfant en développement, qui consiste à mesurer la quantité de sulfate de p-crésol dans l'urine dudit enfant.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| title | p-CRESOL SULFATE, A COMPONENT OF URINARY MYELIN BASIC PROTEIN-LIKE MATERIAL, AS A CORRELATE OF MULTIPLE SCLEROSIS STATUS |
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