INHIBITORS OF STAPHYLOCOCCUS SARA PROTEIN AND THEIR USE IN TREATING STAPHYLOCOCCAL INFECTIONS
The present invention relates to inhibitors of Staphylococcus SarA protein function involved in the expression of staphylococcal virulence factors and the use of these inhibitors to treat and prevent staphylococcal infections in subjects. Particularly, the inhibitors act to interfere with the bindin...
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| creator | HURLBURT, BARRY, K RECHTIN, TAMMY, M SMELTZER, MARK, S |
| description | The present invention relates to inhibitors of Staphylococcus SarA protein function involved in the expression of staphylococcal virulence factors and the use of these inhibitors to treat and prevent staphylococcal infections in subjects. Particularly, the inhibitors act to interfere with the binding of the SarA protein to its binding site(s). The selection of specific inhibitors of the SarA protein is made possible as a result of the identification of the binding sites of SarA protein on at least a portion of the agr (accessory gene regulator) gene, a gene that like the sar (staphylococcal accessory regulator) gene, plays a role in the virulence of Staphylococcus. The present invention also is directed to a method of designing, synthesizing and identifying inhibitors of SarA function and its role in the expression of staphylococcal virulence factors.
L'invention concerne des inhibiteurs de la fonction de la protéine SarA de Staphylococcus, impliquée dans l'expression des facteurs de virulence de staphylococcique et l'utilisation desdits inhibiteurs pour le traitement et la prévention d'infection staphylococciques chez des sujets. Les inhibiteurs agissent notamment pour interférer avec la liaison de la protéine SarA avec son/ses sites de liaison. La sélection d'inhibiteurs spécifiques de la protéine SarA est possible grâce à l'identification des sites de liaison de la protéine SarA sur au moins une partie du gène agr (régulateur de gène accessoire), gène qui comme le gène sar (régulateur accessoire staphylococcique), joue un rôle dans la virulence de Staphylococcus. L'invention porte également sur un procédé de mise au point, de synthèse et d'identification d'inhibiteurs de la fonction de SarA et sur son rôle dans l'expression de facteurs de virulence staphylococcique. |
| format | Patent |
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L'invention concerne des inhibiteurs de la fonction de la protéine SarA de Staphylococcus, impliquée dans l'expression des facteurs de virulence de staphylococcique et l'utilisation desdits inhibiteurs pour le traitement et la prévention d'infection staphylococciques chez des sujets. Les inhibiteurs agissent notamment pour interférer avec la liaison de la protéine SarA avec son/ses sites de liaison. La sélection d'inhibiteurs spécifiques de la protéine SarA est possible grâce à l'identification des sites de liaison de la protéine SarA sur au moins une partie du gène agr (régulateur de gène accessoire), gène qui comme le gène sar (régulateur accessoire staphylococcique), joue un rôle dans la virulence de Staphylococcus. L'invention porte également sur un procédé de mise au point, de synthèse et d'identification d'inhibiteurs de la fonction de SarA et sur son rôle dans l'expression de facteurs de virulence staphylococcique.</description><edition>7</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2001</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010628&DB=EPODOC&CC=WO&NR=0103686A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010628&DB=EPODOC&CC=WO&NR=0103686A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HURLBURT, BARRY, K</creatorcontrib><creatorcontrib>RECHTIN, TAMMY, M</creatorcontrib><creatorcontrib>SMELTZER, MARK, S</creatorcontrib><title>INHIBITORS OF STAPHYLOCOCCUS SARA PROTEIN AND THEIR USE IN TREATING STAPHYLOCOCCAL INFECTIONS</title><description>The present invention relates to inhibitors of Staphylococcus SarA protein function involved in the expression of staphylococcal virulence factors and the use of these inhibitors to treat and prevent staphylococcal infections in subjects. Particularly, the inhibitors act to interfere with the binding of the SarA protein to its binding site(s). The selection of specific inhibitors of the SarA protein is made possible as a result of the identification of the binding sites of SarA protein on at least a portion of the agr (accessory gene regulator) gene, a gene that like the sar (staphylococcal accessory regulator) gene, plays a role in the virulence of Staphylococcus. The present invention also is directed to a method of designing, synthesizing and identifying inhibitors of SarA function and its role in the expression of staphylococcal virulence factors.
L'invention concerne des inhibiteurs de la fonction de la protéine SarA de Staphylococcus, impliquée dans l'expression des facteurs de virulence de staphylococcique et l'utilisation desdits inhibiteurs pour le traitement et la prévention d'infection staphylococciques chez des sujets. Les inhibiteurs agissent notamment pour interférer avec la liaison de la protéine SarA avec son/ses sites de liaison. La sélection d'inhibiteurs spécifiques de la protéine SarA est possible grâce à l'identification des sites de liaison de la protéine SarA sur au moins une partie du gène agr (régulateur de gène accessoire), gène qui comme le gène sar (régulateur accessoire staphylococcique), joue un rôle dans la virulence de Staphylococcus. 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Particularly, the inhibitors act to interfere with the binding of the SarA protein to its binding site(s). The selection of specific inhibitors of the SarA protein is made possible as a result of the identification of the binding sites of SarA protein on at least a portion of the agr (accessory gene regulator) gene, a gene that like the sar (staphylococcal accessory regulator) gene, plays a role in the virulence of Staphylococcus. The present invention also is directed to a method of designing, synthesizing and identifying inhibitors of SarA function and its role in the expression of staphylococcal virulence factors.
L'invention concerne des inhibiteurs de la fonction de la protéine SarA de Staphylococcus, impliquée dans l'expression des facteurs de virulence de staphylococcique et l'utilisation desdits inhibiteurs pour le traitement et la prévention d'infection staphylococciques chez des sujets. Les inhibiteurs agissent notamment pour interférer avec la liaison de la protéine SarA avec son/ses sites de liaison. La sélection d'inhibiteurs spécifiques de la protéine SarA est possible grâce à l'identification des sites de liaison de la protéine SarA sur au moins une partie du gène agr (régulateur de gène accessoire), gène qui comme le gène sar (régulateur accessoire staphylococcique), joue un rôle dans la virulence de Staphylococcus. L'invention porte également sur un procédé de mise au point, de synthèse et d'identification d'inhibiteurs de la fonction de SarA et sur son rôle dans l'expression de facteurs de virulence staphylococcique.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | INHIBITORS OF STAPHYLOCOCCUS SARA PROTEIN AND THEIR USE IN TREATING STAPHYLOCOCCAL INFECTIONS |
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