PURIFIED ANTIGEN FOR ALZHEIMER'S DISEASE, AND METHODS OF OBTAINING AND USING SAME
Disclosed are a preparation comprising Alzheimer's disease antigen (A68), methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detecting human autoantibodies to the Alzheimer disease antigen. The an...
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| creator | DEBERNARDIS, JOHN, FRANCIS KOHNKEN, RUSSEL, EDWIN ZINKOWSKI, RAYMOND, P KERKMAN, DANIEL, JOSEPH |
| description | Disclosed are a preparation comprising Alzheimer's disease antigen (A68), methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detecting human autoantibodies to the Alzheimer disease antigen. The antigen preparation according to the invention is purified in that it is substantially free of immunoglobulin G. The invention further relates to methods of making Alzheimer disease antigens that can be used instead of or along with the A68 antigen preparation (e.g., for diagnosing AD), such as recombinant human tau, tau isolated from various species including human, and phosphorylated recombinant human tau or isolated tau, as well as A68 anti-idiotypic antibodies.
L'invention concerne une préparation contenant un antigène dirigé contre la maladie d'Alzheimer (A68) et des procédés d'utilisation de cet antigène, par exemple, dans le diagnostic de la maladie d'Alzheimer et la détection des auto-anticorps réagissant à l'antigène dirigé contre la maladie d'Alzheimer. On purifie la préparation de l'invention en la libérant sensiblement d'immunoglobuline G. L'invention concerne aussi des procédés de fabrication d'antigènes, dirigés contre la maladie d'Alzheimer et pouvant être utilisés en guise de substitution ou de complément à l'antigène A68 (p.ex., pour diagnostiquer la maladie d'Alzheimer), tels que du tau humain recombinant, du tau isolé à partir de différentes espèces comprenant les humains et du tau humain recombinant isolé ainsi que des anticorps anti-idiotypitques d'A68. |
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L'invention concerne une préparation contenant un antigène dirigé contre la maladie d'Alzheimer (A68) et des procédés d'utilisation de cet antigène, par exemple, dans le diagnostic de la maladie d'Alzheimer et la détection des auto-anticorps réagissant à l'antigène dirigé contre la maladie d'Alzheimer. On purifie la préparation de l'invention en la libérant sensiblement d'immunoglobuline G. L'invention concerne aussi des procédés de fabrication d'antigènes, dirigés contre la maladie d'Alzheimer et pouvant être utilisés en guise de substitution ou de complément à l'antigène A68 (p.ex., pour diagnostiquer la maladie d'Alzheimer), tels que du tau humain recombinant, du tau isolé à partir de différentes espèces comprenant les humains et du tau humain recombinant isolé ainsi que des anticorps anti-idiotypitques d'A68.</description><edition>7</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2000</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20001228&DB=EPODOC&CC=WO&NR=0078807A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20001228&DB=EPODOC&CC=WO&NR=0078807A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DEBERNARDIS, JOHN, FRANCIS</creatorcontrib><creatorcontrib>KOHNKEN, RUSSEL, EDWIN</creatorcontrib><creatorcontrib>ZINKOWSKI, RAYMOND, P</creatorcontrib><creatorcontrib>KERKMAN, DANIEL, JOSEPH</creatorcontrib><title>PURIFIED ANTIGEN FOR ALZHEIMER'S DISEASE, AND METHODS OF OBTAINING AND USING SAME</title><description>Disclosed are a preparation comprising Alzheimer's disease antigen (A68), methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detecting human autoantibodies to the Alzheimer disease antigen. The antigen preparation according to the invention is purified in that it is substantially free of immunoglobulin G. The invention further relates to methods of making Alzheimer disease antigens that can be used instead of or along with the A68 antigen preparation (e.g., for diagnosing AD), such as recombinant human tau, tau isolated from various species including human, and phosphorylated recombinant human tau or isolated tau, as well as A68 anti-idiotypic antibodies.
L'invention concerne une préparation contenant un antigène dirigé contre la maladie d'Alzheimer (A68) et des procédés d'utilisation de cet antigène, par exemple, dans le diagnostic de la maladie d'Alzheimer et la détection des auto-anticorps réagissant à l'antigène dirigé contre la maladie d'Alzheimer. On purifie la préparation de l'invention en la libérant sensiblement d'immunoglobuline G. L'invention concerne aussi des procédés de fabrication d'antigènes, dirigés contre la maladie d'Alzheimer et pouvant être utilisés en guise de substitution ou de complément à l'antigène A68 (p.ex., pour diagnostiquer la maladie d'Alzheimer), tels que du tau humain recombinant, du tau isolé à partir de différentes espèces comprenant les humains et du tau humain recombinant isolé ainsi que des anticorps anti-idiotypitques d'A68.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2000</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAgMCA3ydPN0dVFw9AvxdHf1U3DzD1Jw9InycPX0dQ1SD1Zw8Qx2dQx21QEqcFHwdQ3x8HcJVvB3U_B3CnH09PP0cwdLhAaDWMGOvq48DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSQ-3N_AwNzCwsDc0dCYCCUAB7kufg</recordid><startdate>20001228</startdate><enddate>20001228</enddate><creator>DEBERNARDIS, JOHN, FRANCIS</creator><creator>KOHNKEN, RUSSEL, EDWIN</creator><creator>ZINKOWSKI, RAYMOND, P</creator><creator>KERKMAN, DANIEL, JOSEPH</creator><scope>EVB</scope></search><sort><creationdate>20001228</creationdate><title>PURIFIED ANTIGEN FOR ALZHEIMER'S DISEASE, AND METHODS OF OBTAINING AND USING SAME</title><author>DEBERNARDIS, JOHN, FRANCIS ; KOHNKEN, RUSSEL, EDWIN ; ZINKOWSKI, RAYMOND, P ; KERKMAN, DANIEL, JOSEPH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO0078807A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2000</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>DEBERNARDIS, JOHN, FRANCIS</creatorcontrib><creatorcontrib>KOHNKEN, RUSSEL, EDWIN</creatorcontrib><creatorcontrib>ZINKOWSKI, RAYMOND, P</creatorcontrib><creatorcontrib>KERKMAN, DANIEL, JOSEPH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DEBERNARDIS, JOHN, FRANCIS</au><au>KOHNKEN, RUSSEL, EDWIN</au><au>ZINKOWSKI, RAYMOND, P</au><au>KERKMAN, DANIEL, JOSEPH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PURIFIED ANTIGEN FOR ALZHEIMER'S DISEASE, AND METHODS OF OBTAINING AND USING SAME</title><date>2000-12-28</date><risdate>2000</risdate><abstract>Disclosed are a preparation comprising Alzheimer's disease antigen (A68), methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detecting human autoantibodies to the Alzheimer disease antigen. The antigen preparation according to the invention is purified in that it is substantially free of immunoglobulin G. The invention further relates to methods of making Alzheimer disease antigens that can be used instead of or along with the A68 antigen preparation (e.g., for diagnosing AD), such as recombinant human tau, tau isolated from various species including human, and phosphorylated recombinant human tau or isolated tau, as well as A68 anti-idiotypic antibodies.
L'invention concerne une préparation contenant un antigène dirigé contre la maladie d'Alzheimer (A68) et des procédés d'utilisation de cet antigène, par exemple, dans le diagnostic de la maladie d'Alzheimer et la détection des auto-anticorps réagissant à l'antigène dirigé contre la maladie d'Alzheimer. On purifie la préparation de l'invention en la libérant sensiblement d'immunoglobuline G. L'invention concerne aussi des procédés de fabrication d'antigènes, dirigés contre la maladie d'Alzheimer et pouvant être utilisés en guise de substitution ou de complément à l'antigène A68 (p.ex., pour diagnostiquer la maladie d'Alzheimer), tels que du tau humain recombinant, du tau isolé à partir de différentes espèces comprenant les humains et du tau humain recombinant isolé ainsi que des anticorps anti-idiotypitques d'A68.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS SPIRITS TESTING VINEGAR WINE |
| title | PURIFIED ANTIGEN FOR ALZHEIMER'S DISEASE, AND METHODS OF OBTAINING AND USING SAME |
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