DETECTION OF BIOLOGICAL WARFARE AGENTS
Methods and devices are provided for the detection of bacterial agents such agents as Bacillus anthracis and Clostridium botulinum with high sensitivity and selectivity. More specifically, methods and devices are based on a phosphorescence-emission detection system using chelate-stabilized lantanide...
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| description | Methods and devices are provided for the detection of bacterial agents such agents as Bacillus anthracis and Clostridium botulinum with high sensitivity and selectivity. More specifically, methods and devices are based on a phosphorescence-emission detection system using chelate-stabilized lantanides (e.g, Eu(III), Tb(III), and Sm(III)) to detect various spore-specific small organic molecules (e.g, dipicolinic acid, diaminopimelic acid, n-acetlymuramic acid, and the like). By careful selection of the chelating agent or ligand coordinated to the lanthanide, both high specificity and selectivity can be obtained. Examples of suitable and preferred sensor systems include N-(2-hydroxyethyl)ethylenediaminetriacetic acid (HEDTA) and N-(2-hydroxyethyl)iminodiacetic acid (HEIDA) combined with europium (III) and/or terbium (III). The chelate-stabilized lanthanides react with the spore-specific "target" molecules to form a characteristically phosphorescent product which can then be detected.
L'invention concerne des procédés et des dispositifs servant à détecter des agents bactériens tels que le Bacillus anthracis et le Clostridium botulinum à sensibilité et sélectivité élevées. L'invention concerne plus particulièrement des procédés et des dispositifs utilisant un système de détection d'émission phosphorescente utilisant des lanthanides à chelates stabilisés (p. ex., Eu(III), Tb(III) et Sm(III)) pour détecter diverses petites molécules organiques spécifiques d'une spore (p.ex., l'acide dipicollinique, l'acide diaminopimélique, l'acide n-acéthylmuramique et analogues). Grâce à une soigneuse sélection de l'agent de chélation ou du ligand coordonné au lanthanide, on obtient à la fois une spécificité et une sélectivité élevées. Citons par exemple des systèmes de détection préférés et adéquats comprenant un acide N-(2-hydroxyéthyl)éthylènediaminetriacétique (HEDTA) et un acide N-(2-hydroxyéthyl)iminodiacétique (HEIDA) combinés à un europium (III) et/ou trebium (III). Les lanthanides à chelates stabilisés réagissent aux molécules /= spécifiques d'une spore pour former un produit phosphorescent détectable. |
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L'invention concerne des procédés et des dispositifs servant à détecter des agents bactériens tels que le Bacillus anthracis et le Clostridium botulinum à sensibilité et sélectivité élevées. L'invention concerne plus particulièrement des procédés et des dispositifs utilisant un système de détection d'émission phosphorescente utilisant des lanthanides à chelates stabilisés (p. ex., Eu(III), Tb(III) et Sm(III)) pour détecter diverses petites molécules organiques spécifiques d'une spore (p.ex., l'acide dipicollinique, l'acide diaminopimélique, l'acide n-acéthylmuramique et analogues). Grâce à une soigneuse sélection de l'agent de chélation ou du ligand coordonné au lanthanide, on obtient à la fois une spécificité et une sélectivité élevées. Citons par exemple des systèmes de détection préférés et adéquats comprenant un acide N-(2-hydroxyéthyl)éthylènediaminetriacétique (HEDTA) et un acide N-(2-hydroxyéthyl)iminodiacétique (HEIDA) combinés à un europium (III) et/ou trebium (III). Les lanthanides à chelates stabilisés réagissent aux molécules </= cibles >/= spécifiques d'une spore pour former un produit phosphorescent détectable.</description><edition>7</edition><language>eng ; fre</language><subject>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC ; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS ; TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE ; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE ; TESTING ; VINEGAR ; WINE</subject><creationdate>2001</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010816&DB=EPODOC&CC=WO&NR=0063422A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010816&DB=EPODOC&CC=WO&NR=0063422A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MAINER, STEPHEN, S</creatorcontrib><creatorcontrib>RAJAN, KRISHNASWAMY, S</creatorcontrib><title>DETECTION OF BIOLOGICAL WARFARE AGENTS</title><description>Methods and devices are provided for the detection of bacterial agents such agents as Bacillus anthracis and Clostridium botulinum with high sensitivity and selectivity. More specifically, methods and devices are based on a phosphorescence-emission detection system using chelate-stabilized lantanides (e.g, Eu(III), Tb(III), and Sm(III)) to detect various spore-specific small organic molecules (e.g, dipicolinic acid, diaminopimelic acid, n-acetlymuramic acid, and the like). By careful selection of the chelating agent or ligand coordinated to the lanthanide, both high specificity and selectivity can be obtained. Examples of suitable and preferred sensor systems include N-(2-hydroxyethyl)ethylenediaminetriacetic acid (HEDTA) and N-(2-hydroxyethyl)iminodiacetic acid (HEIDA) combined with europium (III) and/or terbium (III). The chelate-stabilized lanthanides react with the spore-specific "target" molecules to form a characteristically phosphorescent product which can then be detected.
L'invention concerne des procédés et des dispositifs servant à détecter des agents bactériens tels que le Bacillus anthracis et le Clostridium botulinum à sensibilité et sélectivité élevées. L'invention concerne plus particulièrement des procédés et des dispositifs utilisant un système de détection d'émission phosphorescente utilisant des lanthanides à chelates stabilisés (p. ex., Eu(III), Tb(III) et Sm(III)) pour détecter diverses petites molécules organiques spécifiques d'une spore (p.ex., l'acide dipicollinique, l'acide diaminopimélique, l'acide n-acéthylmuramique et analogues). Grâce à une soigneuse sélection de l'agent de chélation ou du ligand coordonné au lanthanide, on obtient à la fois une spécificité et une sélectivité élevées. Citons par exemple des systèmes de détection préférés et adéquats comprenant un acide N-(2-hydroxyéthyl)éthylènediaminetriacétique (HEDTA) et un acide N-(2-hydroxyéthyl)iminodiacétique (HEIDA) combinés à un europium (III) et/ou trebium (III). Les lanthanides à chelates stabilisés réagissent aux molécules </= cibles >/= spécifiques d'une spore pour former un produit phosphorescent détectable.</description><subject>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC</subject><subject>GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS</subject><subject>TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE</subject><subject>TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2001</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFBzcQ1xdQ7x9PdT8HdTcPL09_F393R29FEIdwxycwxyVXB0d_ULCeZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfHh_gYGZsYmRkaOxsZEKAEAcGQjEA</recordid><startdate>20010816</startdate><enddate>20010816</enddate><creator>MAINER, STEPHEN, S</creator><creator>RAJAN, KRISHNASWAMY, S</creator><scope>EVB</scope></search><sort><creationdate>20010816</creationdate><title>DETECTION OF BIOLOGICAL WARFARE AGENTS</title><author>MAINER, STEPHEN, S ; RAJAN, KRISHNASWAMY, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO0063422A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2001</creationdate><topic>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC</topic><topic>GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS</topic><topic>TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE</topic><topic>TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>MAINER, STEPHEN, S</creatorcontrib><creatorcontrib>RAJAN, KRISHNASWAMY, S</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MAINER, STEPHEN, S</au><au>RAJAN, KRISHNASWAMY, S</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DETECTION OF BIOLOGICAL WARFARE AGENTS</title><date>2001-08-16</date><risdate>2001</risdate><abstract>Methods and devices are provided for the detection of bacterial agents such agents as Bacillus anthracis and Clostridium botulinum with high sensitivity and selectivity. More specifically, methods and devices are based on a phosphorescence-emission detection system using chelate-stabilized lantanides (e.g, Eu(III), Tb(III), and Sm(III)) to detect various spore-specific small organic molecules (e.g, dipicolinic acid, diaminopimelic acid, n-acetlymuramic acid, and the like). By careful selection of the chelating agent or ligand coordinated to the lanthanide, both high specificity and selectivity can be obtained. Examples of suitable and preferred sensor systems include N-(2-hydroxyethyl)ethylenediaminetriacetic acid (HEDTA) and N-(2-hydroxyethyl)iminodiacetic acid (HEIDA) combined with europium (III) and/or terbium (III). The chelate-stabilized lanthanides react with the spore-specific "target" molecules to form a characteristically phosphorescent product which can then be detected.
L'invention concerne des procédés et des dispositifs servant à détecter des agents bactériens tels que le Bacillus anthracis et le Clostridium botulinum à sensibilité et sélectivité élevées. L'invention concerne plus particulièrement des procédés et des dispositifs utilisant un système de détection d'émission phosphorescente utilisant des lanthanides à chelates stabilisés (p. ex., Eu(III), Tb(III) et Sm(III)) pour détecter diverses petites molécules organiques spécifiques d'une spore (p.ex., l'acide dipicollinique, l'acide diaminopimélique, l'acide n-acéthylmuramique et analogues). Grâce à une soigneuse sélection de l'agent de chélation ou du ligand coordonné au lanthanide, on obtient à la fois une spécificité et une sélectivité élevées. Citons par exemple des systèmes de détection préférés et adéquats comprenant un acide N-(2-hydroxyéthyl)éthylènediaminetriacétique (HEDTA) et un acide N-(2-hydroxyéthyl)iminodiacétique (HEIDA) combinés à un europium (III) et/ou trebium (III). Les lanthanides à chelates stabilisés réagissent aux molécules </= cibles >/= spécifiques d'une spore pour former un produit phosphorescent détectable.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE TESTING VINEGAR WINE |
| title | DETECTION OF BIOLOGICAL WARFARE AGENTS |
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