ORAL ARGININE AND INSULIN SECRETION
A therapeutically effective amount of L-arginine, or a physiologically acceptable salt thereof, is orally administered, preferably as a food supplement in combination with a meal approved by the American Diabetes Association Inc. ("ADA"), to a person having Type II diabetes mellitus but wh...
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creator | MICHELS, LESTER, DAVID GREENBERG, NORMAN, ALAN GOHMAN, SHARON, MARIE EGBERG, DAVID, CURTIS |
description | A therapeutically effective amount of L-arginine, or a physiologically acceptable salt thereof, is orally administered, preferably as a food supplement in combination with a meal approved by the American Diabetes Association Inc. ("ADA"), to a person having Type II diabetes mellitus but who is not on either insulin or other medication for glycemic control. When 3g to 15g of L-arginine is ingested concurrently with a meal, or immediately prior to eating a meal, the L-arginine decreases the concentration of insulin generated, compared to that generated after the same meal without the L-arginine; at the same time, concentration of glucose in the person's blood is decreased, indicating that available insulin sensitizes cells so as to nearly mimic the effectiveness of normal cells in a non-diabetic person; from 3g to 15g of orally ingested L-arginine, by itself, produces no measurable increase in insulin secretion in a diabetic.
On administre par voie buccale une dose à effet thérapeutique de L-arginine, ou l'un de ses sels physiologiquement acceptables, de préférence comme complément alimentaire d'un repas approuvé par l'American Diabetes Association Inc. ("ADA"), à une personne atteinte de diabète sucré de type II mais non traitée par l'insuline ou d'autres remèdes régulant la glycémie. L'ingestion de 3g à 15g de L-arginine lors d'un repas ou immédiatement avant diminue la concentration d'insuline produite par rapport à ce qu'elle serait après le même repas, sans ingestion de L-arginine. Simultanément la concentration de glucose sanguin baisse ce qui indique que l'insuline disponible sensibilise les cellules de manière à reproduire quasiment l'efficacité des cellules normales chez un non diabétique. Une ingestion de 3g à 15g de L-arginine, seule ne produit pas d'effet mesurable sur la production d'insuline chez le diabétique. |
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On administre par voie buccale une dose à effet thérapeutique de L-arginine, ou l'un de ses sels physiologiquement acceptables, de préférence comme complément alimentaire d'un repas approuvé par l'American Diabetes Association Inc. ("ADA"), à une personne atteinte de diabète sucré de type II mais non traitée par l'insuline ou d'autres remèdes régulant la glycémie. L'ingestion de 3g à 15g de L-arginine lors d'un repas ou immédiatement avant diminue la concentration d'insuline produite par rapport à ce qu'elle serait après le même repas, sans ingestion de L-arginine. Simultanément la concentration de glucose sanguin baisse ce qui indique que l'insuline disponible sensibilise les cellules de manière à reproduire quasiment l'efficacité des cellules normales chez un non diabétique. Une ingestion de 3g à 15g de L-arginine, seule ne produit pas d'effet mesurable sur la production d'insuline chez le diabétique.</description><subject>FOODS OR FOODSTUFFS</subject><subject>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</subject><subject>HUMAN NECESSITIES</subject><subject>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</subject><subject>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2000</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD2D3L0UXAMcvf08_RzVXD0c1Hw9AsO9fH0Uwh2dQ5yDfH09-NhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfHh_gYGJqZmpoaOhsZEKAEAEogiWg</recordid><startdate>20000810</startdate><enddate>20000810</enddate><creator>MICHELS, LESTER, DAVID</creator><creator>GREENBERG, NORMAN, ALAN</creator><creator>GOHMAN, SHARON, MARIE</creator><creator>EGBERG, DAVID, CURTIS</creator><scope>EVB</scope></search><sort><creationdate>20000810</creationdate><title>ORAL ARGININE AND INSULIN SECRETION</title><author>MICHELS, LESTER, DAVID ; GREENBERG, NORMAN, ALAN ; GOHMAN, SHARON, MARIE ; EGBERG, DAVID, CURTIS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO0045651A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2000</creationdate><topic>FOODS OR FOODSTUFFS</topic><topic>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</topic><topic>HUMAN NECESSITIES</topic><topic>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</topic><topic>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><toplevel>online_resources</toplevel><creatorcontrib>MICHELS, LESTER, DAVID</creatorcontrib><creatorcontrib>GREENBERG, NORMAN, ALAN</creatorcontrib><creatorcontrib>GOHMAN, SHARON, MARIE</creatorcontrib><creatorcontrib>EGBERG, DAVID, CURTIS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MICHELS, LESTER, DAVID</au><au>GREENBERG, NORMAN, ALAN</au><au>GOHMAN, SHARON, MARIE</au><au>EGBERG, DAVID, CURTIS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ORAL ARGININE AND INSULIN SECRETION</title><date>2000-08-10</date><risdate>2000</risdate><abstract>A therapeutically effective amount of L-arginine, or a physiologically acceptable salt thereof, is orally administered, preferably as a food supplement in combination with a meal approved by the American Diabetes Association Inc. ("ADA"), to a person having Type II diabetes mellitus but who is not on either insulin or other medication for glycemic control. When 3g to 15g of L-arginine is ingested concurrently with a meal, or immediately prior to eating a meal, the L-arginine decreases the concentration of insulin generated, compared to that generated after the same meal without the L-arginine; at the same time, concentration of glucose in the person's blood is decreased, indicating that available insulin sensitizes cells so as to nearly mimic the effectiveness of normal cells in a non-diabetic person; from 3g to 15g of orally ingested L-arginine, by itself, produces no measurable increase in insulin secretion in a diabetic.
On administre par voie buccale une dose à effet thérapeutique de L-arginine, ou l'un de ses sels physiologiquement acceptables, de préférence comme complément alimentaire d'un repas approuvé par l'American Diabetes Association Inc. ("ADA"), à une personne atteinte de diabète sucré de type II mais non traitée par l'insuline ou d'autres remèdes régulant la glycémie. L'ingestion de 3g à 15g de L-arginine lors d'un repas ou immédiatement avant diminue la concentration d'insuline produite par rapport à ce qu'elle serait après le même repas, sans ingestion de L-arginine. Simultanément la concentration de glucose sanguin baisse ce qui indique que l'insuline disponible sensibilise les cellules de manière à reproduire quasiment l'efficacité des cellules normales chez un non diabétique. Une ingestion de 3g à 15g de L-arginine, seule ne produit pas d'effet mesurable sur la production d'insuline chez le diabétique.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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subjects | FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES |
title | ORAL ARGININE AND INSULIN SECRETION |
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