ORAL ARGININE AND INSULIN SECRETION

A therapeutically effective amount of L-arginine, or a physiologically acceptable salt thereof, is orally administered, preferably as a food supplement in combination with a meal approved by the American Diabetes Association Inc. ("ADA"), to a person having Type II diabetes mellitus but wh...

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Hauptverfasser: MICHELS, LESTER, DAVID, GREENBERG, NORMAN, ALAN, GOHMAN, SHARON, MARIE, EGBERG, DAVID, CURTIS
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GREENBERG, NORMAN, ALAN
GOHMAN, SHARON, MARIE
EGBERG, DAVID, CURTIS
description A therapeutically effective amount of L-arginine, or a physiologically acceptable salt thereof, is orally administered, preferably as a food supplement in combination with a meal approved by the American Diabetes Association Inc. ("ADA"), to a person having Type II diabetes mellitus but who is not on either insulin or other medication for glycemic control. When 3g to 15g of L-arginine is ingested concurrently with a meal, or immediately prior to eating a meal, the L-arginine decreases the concentration of insulin generated, compared to that generated after the same meal without the L-arginine; at the same time, concentration of glucose in the person's blood is decreased, indicating that available insulin sensitizes cells so as to nearly mimic the effectiveness of normal cells in a non-diabetic person; from 3g to 15g of orally ingested L-arginine, by itself, produces no measurable increase in insulin secretion in a diabetic. On administre par voie buccale une dose à effet thérapeutique de L-arginine, ou l'un de ses sels physiologiquement acceptables, de préférence comme complément alimentaire d'un repas approuvé par l'American Diabetes Association Inc. ("ADA"), à une personne atteinte de diabète sucré de type II mais non traitée par l'insuline ou d'autres remèdes régulant la glycémie. L'ingestion de 3g à 15g de L-arginine lors d'un repas ou immédiatement avant diminue la concentration d'insuline produite par rapport à ce qu'elle serait après le même repas, sans ingestion de L-arginine. Simultanément la concentration de glucose sanguin baisse ce qui indique que l'insuline disponible sensibilise les cellules de manière à reproduire quasiment l'efficacité des cellules normales chez un non diabétique. Une ingestion de 3g à 15g de L-arginine, seule ne produit pas d'effet mesurable sur la production d'insuline chez le diabétique.
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("ADA"), à une personne atteinte de diabète sucré de type II mais non traitée par l'insuline ou d'autres remèdes régulant la glycémie. L'ingestion de 3g à 15g de L-arginine lors d'un repas ou immédiatement avant diminue la concentration d'insuline produite par rapport à ce qu'elle serait après le même repas, sans ingestion de L-arginine. Simultanément la concentration de glucose sanguin baisse ce qui indique que l'insuline disponible sensibilise les cellules de manière à reproduire quasiment l'efficacité des cellules normales chez un non diabétique. Une ingestion de 3g à 15g de L-arginine, seule ne produit pas d'effet mesurable sur la production d'insuline chez le diabétique.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
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subjects FOODS OR FOODSTUFFS
FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J
HUMAN NECESSITIES
PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT
THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
title ORAL ARGININE AND INSULIN SECRETION
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