(R)-(2-CLORO-3-(TRIFLUOROMETIL)FENIL)(1-(5-FLUOROPIRIMIDIN2-IL)-4-METIL-6,7-DIHIDRO-1H-[1,2,3]TRIAZOLO-[4,5-C]PIRIDIN5(4H)-IL)METANONA COMO MODULADOR DEL RECEPTOR P2X7
La presente invención divulga al compuesto (R)-(2-cloro-3-(trifluorometi)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanona y a composiciones farmacéuticas que los comprenden. Dicho compuesto actúa biológicamente como modulador del receptor P2X7....
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| creator | Christa C. CHROVIAN Jason C. RECH Neelakandha S. MANI Christine F. GELIN DENG Xiaohu Jessica L. WALL Curt A. DVORAK Manuel Jesús ALCAZAR VACA Meri DE ANGELIS Jimmy T. LIANG Jose Ignacio ANDRES GIL Devin M. SWANSON Akinola SOYODE-JOHNSON Brett D. ALLISON STENNE Brice Heather Renee COATE Michael A. LEVATIC Brad M. SAVALL |
| description | La presente invención divulga al compuesto (R)-(2-cloro-3-(trifluorometi)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanona y a composiciones farmacéuticas que los comprenden. Dicho compuesto actúa biológicamente como modulador del receptor P2X7.
The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb):The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention. |
| format | Patent |
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The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb):The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220930&DB=EPODOC&CC=UY&NR=39887A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220930&DB=EPODOC&CC=UY&NR=39887A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Christa C. CHROVIAN</creatorcontrib><creatorcontrib>Jason C. RECH</creatorcontrib><creatorcontrib>Neelakandha S. MANI</creatorcontrib><creatorcontrib>Christine F. GELIN</creatorcontrib><creatorcontrib>DENG Xiaohu</creatorcontrib><creatorcontrib>Jessica L. WALL</creatorcontrib><creatorcontrib>Curt A. DVORAK</creatorcontrib><creatorcontrib>Manuel Jesús ALCAZAR VACA</creatorcontrib><creatorcontrib>Meri DE ANGELIS</creatorcontrib><creatorcontrib>Jimmy T. LIANG</creatorcontrib><creatorcontrib>Jose Ignacio ANDRES GIL</creatorcontrib><creatorcontrib>Devin M. SWANSON</creatorcontrib><creatorcontrib>Akinola SOYODE-JOHNSON</creatorcontrib><creatorcontrib>Brett D. ALLISON</creatorcontrib><creatorcontrib>STENNE Brice</creatorcontrib><creatorcontrib>Heather Renee COATE</creatorcontrib><creatorcontrib>Michael A. LEVATIC</creatorcontrib><creatorcontrib>Brad M. SAVALL</creatorcontrib><title>(R)-(2-CLORO-3-(TRIFLUOROMETIL)FENIL)(1-(5-FLUOROPIRIMIDIN2-IL)-4-METIL-6,7-DIHIDRO-1H-[1,2,3]TRIAZOLO-[4,5-C]PIRIDIN5(4H)-IL)METANONA COMO MODULADOR DEL RECEPTOR P2X7</title><description>La presente invención divulga al compuesto (R)-(2-cloro-3-(trifluorometi)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanona y a composiciones farmacéuticas que los comprenden. Dicho compuesto actúa biológicamente como modulador del receptor P2X7.
The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb):The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjM0KgkAUhd20iOoRApcjeBf-pS2HmREHRq8MCpWISEyrKMHeqdds-tm3OZdzz_nO0nkS7QEJgSnUCBGQRstctdaUopHKy0VllQRAEvj-a6llKbmsQrAJxPApws5PgctCcjsTFNAFfuhHvV2jJ1QIXewnwPo3bNGExIX3xi1LK6yoy7BEt0TeKspRu1woVwsm6saaOjyka2dxGa-z2fzuytnmomEFmOk-mHkaz-ZmHkN7jPZZltLoX_4CtwdDXw</recordid><startdate>20220930</startdate><enddate>20220930</enddate><creator>Christa C. CHROVIAN</creator><creator>Jason C. RECH</creator><creator>Neelakandha S. MANI</creator><creator>Christine F. GELIN</creator><creator>DENG Xiaohu</creator><creator>Jessica L. WALL</creator><creator>Curt A. DVORAK</creator><creator>Manuel Jesús ALCAZAR VACA</creator><creator>Meri DE ANGELIS</creator><creator>Jimmy T. LIANG</creator><creator>Jose Ignacio ANDRES GIL</creator><creator>Devin M. SWANSON</creator><creator>Akinola SOYODE-JOHNSON</creator><creator>Brett D. ALLISON</creator><creator>STENNE Brice</creator><creator>Heather Renee COATE</creator><creator>Michael A. LEVATIC</creator><creator>Brad M. SAVALL</creator><scope>EVB</scope></search><sort><creationdate>20220930</creationdate><title>(R)-(2-CLORO-3-(TRIFLUOROMETIL)FENIL)(1-(5-FLUOROPIRIMIDIN2-IL)-4-METIL-6,7-DIHIDRO-1H-[1,2,3]TRIAZOLO-[4,5-C]PIRIDIN5(4H)-IL)METANONA COMO MODULADOR DEL RECEPTOR P2X7</title><author>Christa C. CHROVIAN ; Jason C. RECH ; Neelakandha S. MANI ; Christine F. GELIN ; DENG Xiaohu ; Jessica L. WALL ; Curt A. DVORAK ; Manuel Jesús ALCAZAR VACA ; Meri DE ANGELIS ; Jimmy T. LIANG ; Jose Ignacio ANDRES GIL ; Devin M. SWANSON ; Akinola SOYODE-JOHNSON ; Brett D. ALLISON ; STENNE Brice ; Heather Renee COATE ; Michael A. LEVATIC ; Brad M. SAVALL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_UY39887A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Christa C. CHROVIAN</creatorcontrib><creatorcontrib>Jason C. RECH</creatorcontrib><creatorcontrib>Neelakandha S. MANI</creatorcontrib><creatorcontrib>Christine F. GELIN</creatorcontrib><creatorcontrib>DENG Xiaohu</creatorcontrib><creatorcontrib>Jessica L. WALL</creatorcontrib><creatorcontrib>Curt A. DVORAK</creatorcontrib><creatorcontrib>Manuel Jesús ALCAZAR VACA</creatorcontrib><creatorcontrib>Meri DE ANGELIS</creatorcontrib><creatorcontrib>Jimmy T. LIANG</creatorcontrib><creatorcontrib>Jose Ignacio ANDRES GIL</creatorcontrib><creatorcontrib>Devin M. SWANSON</creatorcontrib><creatorcontrib>Akinola SOYODE-JOHNSON</creatorcontrib><creatorcontrib>Brett D. ALLISON</creatorcontrib><creatorcontrib>STENNE Brice</creatorcontrib><creatorcontrib>Heather Renee COATE</creatorcontrib><creatorcontrib>Michael A. LEVATIC</creatorcontrib><creatorcontrib>Brad M. SAVALL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Christa C. CHROVIAN</au><au>Jason C. RECH</au><au>Neelakandha S. MANI</au><au>Christine F. GELIN</au><au>DENG Xiaohu</au><au>Jessica L. WALL</au><au>Curt A. DVORAK</au><au>Manuel Jesús ALCAZAR VACA</au><au>Meri DE ANGELIS</au><au>Jimmy T. LIANG</au><au>Jose Ignacio ANDRES GIL</au><au>Devin M. SWANSON</au><au>Akinola SOYODE-JOHNSON</au><au>Brett D. ALLISON</au><au>STENNE Brice</au><au>Heather Renee COATE</au><au>Michael A. LEVATIC</au><au>Brad M. SAVALL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>(R)-(2-CLORO-3-(TRIFLUOROMETIL)FENIL)(1-(5-FLUOROPIRIMIDIN2-IL)-4-METIL-6,7-DIHIDRO-1H-[1,2,3]TRIAZOLO-[4,5-C]PIRIDIN5(4H)-IL)METANONA COMO MODULADOR DEL RECEPTOR P2X7</title><date>2022-09-30</date><risdate>2022</risdate><abstract>La presente invención divulga al compuesto (R)-(2-cloro-3-(trifluorometi)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanona y a composiciones farmacéuticas que los comprenden. Dicho compuesto actúa biológicamente como modulador del receptor P2X7.
The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb):The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | (R)-(2-CLORO-3-(TRIFLUOROMETIL)FENIL)(1-(5-FLUOROPIRIMIDIN2-IL)-4-METIL-6,7-DIHIDRO-1H-[1,2,3]TRIAZOLO-[4,5-C]PIRIDIN5(4H)-IL)METANONA COMO MODULADOR DEL RECEPTOR P2X7 |
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