Method for producing optically active, racemic menthol

Method for producing optically active, racemic menthol

The present invention relates to a particularly economic overall method for producing menthol, specifically for producing optically active, essentially enantiomerically and diastereomerically pure L-menthol and racemic menthol, starting from the starting material citral which is available inexpensiv...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Krause, Wolfgang, Oehlenschläger, Steffen, Jäkel, Christoph, Heydrich, Gunnar, Ebel, Klaus, Kashani-Shirazi, Nawid, Rauls, Matthias, Paciello, Rocco, Gralla, Gabriele, Friedrich, Marko, Schmidt-Leithoff, Joachim, Bergner, Eike Johannes
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a particularly economic overall method for producing menthol, specifically for producing optically active, essentially enantiomerically and diastereomerically pure L-menthol and racemic menthol, starting from the starting material citral which is available inexpensively on an industrial scale. The method comprises the following steps a) catalytic hydrogenation of neral and/or geranial to give citronellal, b) cyclization of citronellal to isopulegol in the presence of an acidic catalyst, c) purification of isopulegol by crystallization and d) catalytic hydrogenation of isopulegol to give menthol.