Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof
The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such comp...
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| creator | Guru Santosh K Pathania Anup S Kumar Suresh Vishwakarma Ram A Mintoo Mubashir J Bharate Sandip B Bhushan Shashi Meena Samdarshi Bharate Sonali S Behl Akanksha Jain Shreyans K Joshi Prashant Mondhe Dilip M |
| description | The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond. |
| format | Patent |
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In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180403&DB=EPODOC&CC=US&NR=9932327B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180403&DB=EPODOC&CC=US&NR=9932327B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Guru Santosh K</creatorcontrib><creatorcontrib>Pathania Anup S</creatorcontrib><creatorcontrib>Kumar Suresh</creatorcontrib><creatorcontrib>Vishwakarma Ram A</creatorcontrib><creatorcontrib>Mintoo Mubashir J</creatorcontrib><creatorcontrib>Bharate Sandip B</creatorcontrib><creatorcontrib>Bhushan Shashi</creatorcontrib><creatorcontrib>Meena Samdarshi</creatorcontrib><creatorcontrib>Bharate Sonali S</creatorcontrib><creatorcontrib>Behl Akanksha</creatorcontrib><creatorcontrib>Jain Shreyans K</creatorcontrib><creatorcontrib>Joshi Prashant</creatorcontrib><creatorcontrib>Mondhe Dilip M</creatorcontrib><title>Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof</title><description>The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof |
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