Macrocyclic compounds as protein kinase inhibitors
There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or...
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| creator | Álvarez Escobar Rosa María Riesco Fagundo Rosario Concepción Martín Hernando Jose Ignacio Rodríguez Hergueta Antonio Blanco Aparicio Carmen García García Ana Belén Pastor Fernández Joaquín Cebrián Muñoz David Álvaro |
| description | There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds. |
| format | Patent |
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The invention also relates to combinations containing such compounds.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171107&DB=EPODOC&CC=US&NR=9808466B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171107&DB=EPODOC&CC=US&NR=9808466B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Álvarez Escobar Rosa María</creatorcontrib><creatorcontrib>Riesco Fagundo Rosario Concepción</creatorcontrib><creatorcontrib>Martín Hernando Jose Ignacio</creatorcontrib><creatorcontrib>Rodríguez Hergueta Antonio</creatorcontrib><creatorcontrib>Blanco Aparicio Carmen</creatorcontrib><creatorcontrib>García García Ana Belén</creatorcontrib><creatorcontrib>Pastor Fernández Joaquín</creatorcontrib><creatorcontrib>Cebrián Muñoz David Álvaro</creatorcontrib><title>Macrocyclic compounds as protein kinase inhibitors</title><description>There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDyTUwuyk-uTM7JTFZIzs8tyC_NSylWSCxWKCjKL0nNzFPIzsxLLE5VyMzLyEzKLMkvKuZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGhwZYWBhYmZmZORsZEKAEAr3UsaQ</recordid><startdate>20171107</startdate><enddate>20171107</enddate><creator>Álvarez Escobar Rosa María</creator><creator>Riesco Fagundo Rosario Concepción</creator><creator>Martín Hernando Jose Ignacio</creator><creator>Rodríguez Hergueta Antonio</creator><creator>Blanco Aparicio Carmen</creator><creator>García García Ana Belén</creator><creator>Pastor Fernández Joaquín</creator><creator>Cebrián Muñoz David Álvaro</creator><scope>EVB</scope></search><sort><creationdate>20171107</creationdate><title>Macrocyclic compounds as protein kinase inhibitors</title><author>Álvarez Escobar Rosa María ; Riesco Fagundo Rosario Concepción ; Martín Hernando Jose Ignacio ; Rodríguez Hergueta Antonio ; Blanco Aparicio Carmen ; García García Ana Belén ; Pastor Fernández Joaquín ; Cebrián Muñoz David Álvaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US9808466B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Álvarez Escobar Rosa María</creatorcontrib><creatorcontrib>Riesco Fagundo Rosario Concepción</creatorcontrib><creatorcontrib>Martín Hernando Jose Ignacio</creatorcontrib><creatorcontrib>Rodríguez Hergueta Antonio</creatorcontrib><creatorcontrib>Blanco Aparicio Carmen</creatorcontrib><creatorcontrib>García García Ana Belén</creatorcontrib><creatorcontrib>Pastor Fernández Joaquín</creatorcontrib><creatorcontrib>Cebrián Muñoz David Álvaro</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Álvarez Escobar Rosa María</au><au>Riesco Fagundo Rosario Concepción</au><au>Martín Hernando Jose Ignacio</au><au>Rodríguez Hergueta Antonio</au><au>Blanco Aparicio Carmen</au><au>García García Ana Belén</au><au>Pastor Fernández Joaquín</au><au>Cebrián Muñoz David Álvaro</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Macrocyclic compounds as protein kinase inhibitors</title><date>2017-11-07</date><risdate>2017</risdate><abstract>There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Macrocyclic compounds as protein kinase inhibitors |
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