Amidopyridinol derivative or pharmaceutically acceptable salt thereof and pharmaceutical composition comprising same as active component

An amidopyridinol derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including the amidopyridinol derivative as an active component represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof have an antiangiogenic effect in a chorioallanto...

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Hauptverfasser: Jin You Jin, Kang You Ra, Jeong Byeong Seon, Been Jae Hui, Lee Hyun Ji, Nam Tae gyu, Regmi Sushil Chandra, Kim Dong Guk, Gautam Jaya, Kim Jung Ae
Format: Patent
Sprache:eng
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Zusammenfassung:An amidopyridinol derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including the amidopyridinol derivative as an active component represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof have an antiangiogenic effect in a chorioallantoic membrane model, and thus are useful as an agent for preventing or treating diseases associated with angiogenesis, and also have a colitis-inhibitory effect in a model of inflammatory bowel diseases, and thus are useful as an agent for preventing or treating inflammatory bowel diseases. Upon inoculation of lung cancer cells in a chorioallantoic membrane model, the amidopyridinol derivative of Chemical Formula 1 or the pharmaceutically acceptable salt thereof inhibits angiogenesis and tumor growth that are caused by tumorigenesis, and also inhibits the activity of cathepsin S that plays an important role in metastasis and invasion of cancer, and thus is useful as an inhibitor of cancer growth and metastasis.