Sustained-release solid preparation for oral use

It is intended to avoid dose dumping of a drug and improve the dissolution properties of the drug in the lower gastrointestinal tract, and thereby provide a sustained-release matrix preparation for oral administration that reliably exhibits its main pharmacological effect when orally administered on...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Fukui Sachiko, Yoshida Kazuhiro, Kanamaru Taro, Tajiri Shinichiro
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:It is intended to avoid dose dumping of a drug and improve the dissolution properties of the drug in the lower gastrointestinal tract, and thereby provide a sustained-release matrix preparation for oral administration that reliably exhibits its main pharmacological effect when orally administered once or twice a day. The present invention provides a sustained-release matrix preparation comprising (A) a pharmacologically active drug, (B) a combination of cellulose derivatives, and (C) mannitol.