Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular...
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| creator | Green Bruce Arthur Freese Stephen John Jansen Kathrin Ute Nanra Jasdeep Singh Prasad A. Krishna Scully Ingrid Lea Anderson Annaliesa Pavliak Viliam Scott Tracy Dee |
| description | The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carbonyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH). |
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Krishna ; Scully Ingrid Lea ; Anderson Annaliesa ; Pavliak Viliam ; Scott Tracy Dee</creator><creatorcontrib>Green Bruce Arthur ; Freese Stephen John ; Jansen Kathrin Ute ; Nanra Jasdeep Singh ; Prasad A. Krishna ; Scully Ingrid Lea ; Anderson Annaliesa ; Pavliak Viliam ; Scott Tracy Dee</creatorcontrib><description>The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. 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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
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