Endoscope for analyte consumption rate determination with single cell resolution for in vivo applications

Endoscope for analyte consumption rate determination with single cell resolution for in vivo applications

Novel methods and devices including modified endoscopes that employ fiber optic technology and multiple extrinsic optical sensors for enablement of simultaneous determination of change rates of biological analytes in vivo with single-cell resolution. The devices employ dynamic oscillatory actuation...

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Hauptverfasser: Meldrum Deirdre, Houkal Jeff, Youngbull Cody, Johnson Roger, Kelbauskas Laimonas, Tian Yanqing
Format: Patent
Sprache:eng
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DIAGNOSIS
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
MEDICAL OR VETERINARY SCIENCE
SURGERY
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creator Meldrum Deirdre
Houkal Jeff
Youngbull Cody
Johnson Roger
Kelbauskas Laimonas
Tian Yanqing
description Novel methods and devices including modified endoscopes that employ fiber optic technology and multiple extrinsic optical sensors for enablement of simultaneous determination of change rates of biological analytes in vivo with single-cell resolution. The devices employ dynamic oscillatory actuation to determine the gradient of analytes of interest along one or multiple directions with respect to the cell. The change rate or flux of the analyte of interest can be easily determined by applying the first Fick's law that relates the flux with the concentration gradient. The dual operation mode of the device markedly increases measurement sensitivity and accuracy.
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subjects DIAGNOSIS
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
MEDICAL OR VETERINARY SCIENCE
SURGERY
title Endoscope for analyte consumption rate determination with single cell resolution for in vivo applications
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