Antibodies against nerve growth factor (NGF) with enhanced in vivo stability

The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-...

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Bibliographische Detailangaben

Hauptverfasser:	Casson Duncan, Best Andrea, Hall Jerry A, Powell John, Liu Wei, Dutta Sandeep, Maginn Mark
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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