Tromethamine salt of bimatoprost acid in crystalline form, methods for preparation, and methods for use thereof

Tromethamine salt of bimatoprost acid in crystalline form, methods for preparation, and methods for use thereof

The present invention provides tromethamine salt of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline and amorphous form. This compound is may also be referred to as "tromethamine salt of bimatoprost acid." The invention crystalline form is u...

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Hauptverfasser: St. Clair Brown Adrian, Karami Thomas K, Smith Scott W, Dubas-Fisher Fiona
Format: Patent
Sprache:eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator St. Clair Brown Adrian
Karami Thomas K
Smith Scott W
Dubas-Fisher Fiona
description The present invention provides tromethamine salt of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline and amorphous form. This compound is may also be referred to as "tromethamine salt of bimatoprost acid." The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Tromethamine salt of bimatoprost acid in crystalline form, methods for preparation, and methods for use thereof
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