Conjugated biological molecules and their preparation
A process for the preparation of a compound of the general formula: in which one of X and X' represents polyethylene glycol, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents a keto group CO, an ester group -O-CO- or a sulphone group -SO 2 -...
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| creator | Brocchini Stephen James Godwin Antony Robert Pedone Elisa Shaunak Sunil Choi Ji-Won |
| description | A process for the preparation of a compound of the general formula:
in which one of X and X' represents polyethylene glycol, and the other represents a hydrogen atom;
each Q independently represents a linking group;
W represents a keto group CO, an ester group -O-CO- or a sulphone group -SO 2 -, or a group obtained by reduction of such a group; or, if X' represents polyethylene glycol, X-Q-W-together represent a cyano group;
Z represents a protein which is linked to A and B via two thiol groups which have been derived from a disulphide bridge in the protein; A is a C 1-5 alkylene or alkenylene chain; and
B is a bond or a C 1-4 alkylene or alkenylene chain; which comprises reducing a disulfide bridge in a protein, and reacting the resultant product in an aqueous reaction medium with either (i) a compound of the general formula
in which X, X', Q, A, B and L have the meanings given above, W' represents a keto or aldehyde group CO, an ester group
-O-CO- or a sulphone group -SO 2 -, and each L independently represents a leaving group;
or (ii) a compound of the general formula
in which X, X', Q, W', A and L have the meanings given for the general formula II, and m represents an integer 1 to 4. Also claimed is novel intermediate ±-methoxy-É-4-[2,2-bis[(p-tolylsulfonyl)methyl]-acetyl]benzamide poly(ethylene glycol). |
| format | Patent |
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in which one of X and X' represents polyethylene glycol, and the other represents a hydrogen atom;
each Q independently represents a linking group;
W represents a keto group CO, an ester group -O-CO- or a sulphone group -SO 2 -, or a group obtained by reduction of such a group; or, if X' represents polyethylene glycol, X-Q-W-together represent a cyano group;
Z represents a protein which is linked to A and B via two thiol groups which have been derived from a disulphide bridge in the protein; A is a C 1-5 alkylene or alkenylene chain; and
B is a bond or a C 1-4 alkylene or alkenylene chain; which comprises reducing a disulfide bridge in a protein, and reacting the resultant product in an aqueous reaction medium with either (i) a compound of the general formula
in which X, X', Q, A, B and L have the meanings given above, W' represents a keto or aldehyde group CO, an ester group
-O-CO- or a sulphone group -SO 2 -, and each L independently represents a leaving group;
or (ii) a compound of the general formula
in which X, X', Q, W', A and L have the meanings given for the general formula II, and m represents an integer 1 to 4. Also claimed is novel intermediate ±-methoxy-É-4-[2,2-bis[(p-tolylsulfonyl)methyl]-acetyl]benzamide poly(ethylene glycol).</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160913&DB=EPODOC&CC=US&NR=9439974B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160913&DB=EPODOC&CC=US&NR=9439974B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Brocchini Stephen James</creatorcontrib><creatorcontrib>Godwin Antony Robert</creatorcontrib><creatorcontrib>Pedone Elisa</creatorcontrib><creatorcontrib>Shaunak Sunil</creatorcontrib><creatorcontrib>Choi Ji-Won</creatorcontrib><title>Conjugated biological molecules and their preparation</title><description>A process for the preparation of a compound of the general formula:
in which one of X and X' represents polyethylene glycol, and the other represents a hydrogen atom;
each Q independently represents a linking group;
W represents a keto group CO, an ester group -O-CO- or a sulphone group -SO 2 -, or a group obtained by reduction of such a group; or, if X' represents polyethylene glycol, X-Q-W-together represent a cyano group;
Z represents a protein which is linked to A and B via two thiol groups which have been derived from a disulphide bridge in the protein; A is a C 1-5 alkylene or alkenylene chain; and
B is a bond or a C 1-4 alkylene or alkenylene chain; which comprises reducing a disulfide bridge in a protein, and reacting the resultant product in an aqueous reaction medium with either (i) a compound of the general formula
in which X, X', Q, A, B and L have the meanings given above, W' represents a keto or aldehyde group CO, an ester group
-O-CO- or a sulphone group -SO 2 -, and each L independently represents a leaving group;
or (ii) a compound of the general formula
in which X, X', Q, W', A and L have the meanings given for the general formula II, and m represents an integer 1 to 4. Also claimed is novel intermediate ±-methoxy-É-4-[2,2-bis[(p-tolylsulfonyl)methyl]-acetyl]benzamide poly(ethylene glycol).</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB1zs_LKk1PLElNUUjKzM_JT89MTsxRyM3PSU0uzUktVkjMS1EoyUjNLFIoKEotSCxKLMnMz-NhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGhwZYmxpaW5iZORsZEKAEARVctfg</recordid><startdate>20160913</startdate><enddate>20160913</enddate><creator>Brocchini Stephen James</creator><creator>Godwin Antony Robert</creator><creator>Pedone Elisa</creator><creator>Shaunak Sunil</creator><creator>Choi Ji-Won</creator><scope>EVB</scope></search><sort><creationdate>20160913</creationdate><title>Conjugated biological molecules and their preparation</title><author>Brocchini Stephen James ; Godwin Antony Robert ; Pedone Elisa ; Shaunak Sunil ; Choi Ji-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US9439974B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Brocchini Stephen James</creatorcontrib><creatorcontrib>Godwin Antony Robert</creatorcontrib><creatorcontrib>Pedone Elisa</creatorcontrib><creatorcontrib>Shaunak Sunil</creatorcontrib><creatorcontrib>Choi Ji-Won</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Brocchini Stephen James</au><au>Godwin Antony Robert</au><au>Pedone Elisa</au><au>Shaunak Sunil</au><au>Choi Ji-Won</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Conjugated biological molecules and their preparation</title><date>2016-09-13</date><risdate>2016</risdate><abstract>A process for the preparation of a compound of the general formula:
in which one of X and X' represents polyethylene glycol, and the other represents a hydrogen atom;
each Q independently represents a linking group;
W represents a keto group CO, an ester group -O-CO- or a sulphone group -SO 2 -, or a group obtained by reduction of such a group; or, if X' represents polyethylene glycol, X-Q-W-together represent a cyano group;
Z represents a protein which is linked to A and B via two thiol groups which have been derived from a disulphide bridge in the protein; A is a C 1-5 alkylene or alkenylene chain; and
B is a bond or a C 1-4 alkylene or alkenylene chain; which comprises reducing a disulfide bridge in a protein, and reacting the resultant product in an aqueous reaction medium with either (i) a compound of the general formula
in which X, X', Q, A, B and L have the meanings given above, W' represents a keto or aldehyde group CO, an ester group
-O-CO- or a sulphone group -SO 2 -, and each L independently represents a leaving group;
or (ii) a compound of the general formula
in which X, X', Q, W', A and L have the meanings given for the general formula II, and m represents an integer 1 to 4. Also claimed is novel intermediate ±-methoxy-É-4-[2,2-bis[(p-tolylsulfonyl)methyl]-acetyl]benzamide poly(ethylene glycol).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Conjugated biological molecules and their preparation |
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