KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy

KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy

The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthe...

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Bibliographische Detailangaben
Hauptverfasser: Marinelli Edmund R, Nanjappan Palaniappa, Yan Feng, Linder Karen E, Pillai Radhakrishna K, Khurana Sudha, Von Wronski Mathew A, Arbogast Christophe, Fan Hong (Helen), Shrivastava Ajay, Nunn Adrian D, Pochon Sibylle, Song Bo, Ramalingam Kondareddiar, Swenson Rolf E, Bussat Philippe
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD