N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels

N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels

Disclosed are compounds of Formula AA and Formula AB: wherein "Heteroaryl-1", RA1, RA2, RB1, and RC are defined herein, which novel compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations compri...

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Hauptverfasser: KELLY, III MICHAEL J, PERO JOSEPH E, LEHMAN HANNAH D. G. F, ROSSI MICHAEL A, LAYTON MARK E
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator KELLY, III MICHAEL J
PERO JOSEPH E
LEHMAN HANNAH D. G. F
ROSSI MICHAEL A
LAYTON MARK E
description Disclosed are compounds of Formula AA and Formula AB: wherein "Heteroaryl-1", RA1, RA2, RB1, and RC are defined herein, which novel compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formulae AA and AB or their salts, and methods of treating neuropathic pain disorders using the same.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels
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