Macrocyclic compounds as protein kinase inhibitors
There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | RIESCO FAGUNDO ROSARIO CONCEPCIÓN RODRIGUEZ HERGUETA ANTONIO BLANCO APARICÍO CARMEN CEBRIÁN MUÑOZ DAVID ÁLVARO ÁLVAREZ ESCOBAR ROSA MARIA PASTOR FERNÁNDEZ JOAQUIN MARTÍN HERNANDO JOSE IGNACIO GARCÍA GARCÍA ANA BELÉN |
| description | There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US9284334B2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US9284334B2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US9284334B23</originalsourceid><addsrcrecordid>eNrjZDDyTUwuyk-uTM7JTFZIzs8tyC_NSylWSCxWKCjKL0nNzFPIzsxLLE5VyMzLyEzKLMkvKuZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGhwZZGFibGxiZORsZEKAEArf8sWQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Macrocyclic compounds as protein kinase inhibitors</title><source>esp@cenet</source><creator>RIESCO FAGUNDO ROSARIO CONCEPCIÓN ; RODRIGUEZ HERGUETA ANTONIO ; BLANCO APARICÍO CARMEN ; CEBRIÁN MUÑOZ DAVID ÁLVARO ; ÁLVAREZ ESCOBAR ROSA MARIA ; PASTOR FERNÁNDEZ JOAQUIN ; MARTÍN HERNANDO JOSE IGNACIO ; GARCÍA GARCÍA ANA BELÉN</creator><creatorcontrib>RIESCO FAGUNDO ROSARIO CONCEPCIÓN ; RODRIGUEZ HERGUETA ANTONIO ; BLANCO APARICÍO CARMEN ; CEBRIÁN MUÑOZ DAVID ÁLVARO ; ÁLVAREZ ESCOBAR ROSA MARIA ; PASTOR FERNÁNDEZ JOAQUIN ; MARTÍN HERNANDO JOSE IGNACIO ; GARCÍA GARCÍA ANA BELÉN</creatorcontrib><description>There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160315&DB=EPODOC&CC=US&NR=9284334B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160315&DB=EPODOC&CC=US&NR=9284334B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RIESCO FAGUNDO ROSARIO CONCEPCIÓN</creatorcontrib><creatorcontrib>RODRIGUEZ HERGUETA ANTONIO</creatorcontrib><creatorcontrib>BLANCO APARICÍO CARMEN</creatorcontrib><creatorcontrib>CEBRIÁN MUÑOZ DAVID ÁLVARO</creatorcontrib><creatorcontrib>ÁLVAREZ ESCOBAR ROSA MARIA</creatorcontrib><creatorcontrib>PASTOR FERNÁNDEZ JOAQUIN</creatorcontrib><creatorcontrib>MARTÍN HERNANDO JOSE IGNACIO</creatorcontrib><creatorcontrib>GARCÍA GARCÍA ANA BELÉN</creatorcontrib><title>Macrocyclic compounds as protein kinase inhibitors</title><description>There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDyTUwuyk-uTM7JTFZIzs8tyC_NSylWSCxWKCjKL0nNzFPIzsxLLE5VyMzLyEzKLMkvKuZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGhwZZGFibGxiZORsZEKAEArf8sWQ</recordid><startdate>20160315</startdate><enddate>20160315</enddate><creator>RIESCO FAGUNDO ROSARIO CONCEPCIÓN</creator><creator>RODRIGUEZ HERGUETA ANTONIO</creator><creator>BLANCO APARICÍO CARMEN</creator><creator>CEBRIÁN MUÑOZ DAVID ÁLVARO</creator><creator>ÁLVAREZ ESCOBAR ROSA MARIA</creator><creator>PASTOR FERNÁNDEZ JOAQUIN</creator><creator>MARTÍN HERNANDO JOSE IGNACIO</creator><creator>GARCÍA GARCÍA ANA BELÉN</creator><scope>EVB</scope></search><sort><creationdate>20160315</creationdate><title>Macrocyclic compounds as protein kinase inhibitors</title><author>RIESCO FAGUNDO ROSARIO CONCEPCIÓN ; RODRIGUEZ HERGUETA ANTONIO ; BLANCO APARICÍO CARMEN ; CEBRIÁN MUÑOZ DAVID ÁLVARO ; ÁLVAREZ ESCOBAR ROSA MARIA ; PASTOR FERNÁNDEZ JOAQUIN ; MARTÍN HERNANDO JOSE IGNACIO ; GARCÍA GARCÍA ANA BELÉN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US9284334B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>RIESCO FAGUNDO ROSARIO CONCEPCIÓN</creatorcontrib><creatorcontrib>RODRIGUEZ HERGUETA ANTONIO</creatorcontrib><creatorcontrib>BLANCO APARICÍO CARMEN</creatorcontrib><creatorcontrib>CEBRIÁN MUÑOZ DAVID ÁLVARO</creatorcontrib><creatorcontrib>ÁLVAREZ ESCOBAR ROSA MARIA</creatorcontrib><creatorcontrib>PASTOR FERNÁNDEZ JOAQUIN</creatorcontrib><creatorcontrib>MARTÍN HERNANDO JOSE IGNACIO</creatorcontrib><creatorcontrib>GARCÍA GARCÍA ANA BELÉN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RIESCO FAGUNDO ROSARIO CONCEPCIÓN</au><au>RODRIGUEZ HERGUETA ANTONIO</au><au>BLANCO APARICÍO CARMEN</au><au>CEBRIÁN MUÑOZ DAVID ÁLVARO</au><au>ÁLVAREZ ESCOBAR ROSA MARIA</au><au>PASTOR FERNÁNDEZ JOAQUIN</au><au>MARTÍN HERNANDO JOSE IGNACIO</au><au>GARCÍA GARCÍA ANA BELÉN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Macrocyclic compounds as protein kinase inhibitors</title><date>2016-03-15</date><risdate>2016</risdate><abstract>There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US9284334B2 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Macrocyclic compounds as protein kinase inhibitors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T11%3A14%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=RIESCO%20FAGUNDO%20ROSARIO%20CONCEPCI%C3%93N&rft.date=2016-03-15&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS9284334B2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |