Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and p...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | WERNE GERALD FU XIAOYONG CHEN FRANK XING MERGELSBERG INGRID XIE JI CASTELLANOS LOUIS PETER ORR ROBERT K CUI JIAN ZHANG FUCHENG POIRIER MARC WU GEORGE G ZENG LIANSHENG SPRAGUE VICTORIA M CHEN YUYIN |
| description | This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US9249144B2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US9249144B2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US9249144B23</originalsourceid><addsrcrecordid>eNqNjTEKwkAQRdNYiHqHKRUyQmJEbRXFUlArkbAmE7KQ7Cw7GzCKB_G2BvQAVo__34ffD94HxxmJgDI5aOPJ1ZRr5UmgYAe-JJDWdBAtwAUs8fKMcDwL53jTgmPvdFE17LgmX7bVxJZkOmCX-N6-8FtfcYlfg1G4wO7goVCsdnxJpvNrTpkyGCMbgoxry43JZRj0ClUJjX4cBLDbnjZ7JMspiVUZGfLp-biKk1WUJOt49sfkA9S0UFY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds</title><source>esp@cenet</source><creator>WERNE GERALD ; FU XIAOYONG ; CHEN FRANK XING ; MERGELSBERG INGRID ; XIE JI ; CASTELLANOS LOUIS PETER ; ORR ROBERT K ; CUI JIAN ; ZHANG FUCHENG ; POIRIER MARC ; WU GEORGE G ; ZENG LIANSHENG ; SPRAGUE VICTORIA M ; CHEN YUYIN</creator><creatorcontrib>WERNE GERALD ; FU XIAOYONG ; CHEN FRANK XING ; MERGELSBERG INGRID ; XIE JI ; CASTELLANOS LOUIS PETER ; ORR ROBERT K ; CUI JIAN ; ZHANG FUCHENG ; POIRIER MARC ; WU GEORGE G ; ZENG LIANSHENG ; SPRAGUE VICTORIA M ; CHEN YUYIN</creatorcontrib><description>This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160202&DB=EPODOC&CC=US&NR=9249144B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160202&DB=EPODOC&CC=US&NR=9249144B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WERNE GERALD</creatorcontrib><creatorcontrib>FU XIAOYONG</creatorcontrib><creatorcontrib>CHEN FRANK XING</creatorcontrib><creatorcontrib>MERGELSBERG INGRID</creatorcontrib><creatorcontrib>XIE JI</creatorcontrib><creatorcontrib>CASTELLANOS LOUIS PETER</creatorcontrib><creatorcontrib>ORR ROBERT K</creatorcontrib><creatorcontrib>CUI JIAN</creatorcontrib><creatorcontrib>ZHANG FUCHENG</creatorcontrib><creatorcontrib>POIRIER MARC</creatorcontrib><creatorcontrib>WU GEORGE G</creatorcontrib><creatorcontrib>ZENG LIANSHENG</creatorcontrib><creatorcontrib>SPRAGUE VICTORIA M</creatorcontrib><creatorcontrib>CHEN YUYIN</creatorcontrib><title>Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds</title><description>This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjTEKwkAQRdNYiHqHKRUyQmJEbRXFUlArkbAmE7KQ7Cw7GzCKB_G2BvQAVo__34ffD94HxxmJgDI5aOPJ1ZRr5UmgYAe-JJDWdBAtwAUs8fKMcDwL53jTgmPvdFE17LgmX7bVxJZkOmCX-N6-8FtfcYlfg1G4wO7goVCsdnxJpvNrTpkyGCMbgoxry43JZRj0ClUJjX4cBLDbnjZ7JMspiVUZGfLp-biKk1WUJOt49sfkA9S0UFY</recordid><startdate>20160202</startdate><enddate>20160202</enddate><creator>WERNE GERALD</creator><creator>FU XIAOYONG</creator><creator>CHEN FRANK XING</creator><creator>MERGELSBERG INGRID</creator><creator>XIE JI</creator><creator>CASTELLANOS LOUIS PETER</creator><creator>ORR ROBERT K</creator><creator>CUI JIAN</creator><creator>ZHANG FUCHENG</creator><creator>POIRIER MARC</creator><creator>WU GEORGE G</creator><creator>ZENG LIANSHENG</creator><creator>SPRAGUE VICTORIA M</creator><creator>CHEN YUYIN</creator><scope>EVB</scope></search><sort><creationdate>20160202</creationdate><title>Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds</title><author>WERNE GERALD ; FU XIAOYONG ; CHEN FRANK XING ; MERGELSBERG INGRID ; XIE JI ; CASTELLANOS LOUIS PETER ; ORR ROBERT K ; CUI JIAN ; ZHANG FUCHENG ; POIRIER MARC ; WU GEORGE G ; ZENG LIANSHENG ; SPRAGUE VICTORIA M ; CHEN YUYIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US9249144B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2016</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>WERNE GERALD</creatorcontrib><creatorcontrib>FU XIAOYONG</creatorcontrib><creatorcontrib>CHEN FRANK XING</creatorcontrib><creatorcontrib>MERGELSBERG INGRID</creatorcontrib><creatorcontrib>XIE JI</creatorcontrib><creatorcontrib>CASTELLANOS LOUIS PETER</creatorcontrib><creatorcontrib>ORR ROBERT K</creatorcontrib><creatorcontrib>CUI JIAN</creatorcontrib><creatorcontrib>ZHANG FUCHENG</creatorcontrib><creatorcontrib>POIRIER MARC</creatorcontrib><creatorcontrib>WU GEORGE G</creatorcontrib><creatorcontrib>ZENG LIANSHENG</creatorcontrib><creatorcontrib>SPRAGUE VICTORIA M</creatorcontrib><creatorcontrib>CHEN YUYIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WERNE GERALD</au><au>FU XIAOYONG</au><au>CHEN FRANK XING</au><au>MERGELSBERG INGRID</au><au>XIE JI</au><au>CASTELLANOS LOUIS PETER</au><au>ORR ROBERT K</au><au>CUI JIAN</au><au>ZHANG FUCHENG</au><au>POIRIER MARC</au><au>WU GEORGE G</au><au>ZENG LIANSHENG</au><au>SPRAGUE VICTORIA M</au><au>CHEN YUYIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds</title><date>2016-02-02</date><risdate>2016</risdate><abstract>This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US9249144B2 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T06%3A36%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=WERNE%20GERALD&rft.date=2016-02-02&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS9249144B2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |