Fluorination process
The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10a...
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| creator | LASBISTES NICHOLAS GIBSON ALEXANDER MARK KARIMI FARHAD BOUVET DENIS RAYMOND CHRISTOPHE LANGSTROM BENGT JONES CLARE LOUISE FAIRWAY STEVEN MICHAEL NAIRNE ROBERT JAMES WILLIAMS LORENZO STOREY ANTHONY EAMON |
| description | The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, -(CH2CH2O)q-CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed. |
| format | Patent |
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Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; NUCLEAR ENGINEERING ; NUCLEAR PHYSICS ; NUCLEAR REACTORS ; ORGANIC CHEMISTRY ; PHYSICS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150908&DB=EPODOC&CC=US&NR=9126961B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150908&DB=EPODOC&CC=US&NR=9126961B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LASBISTES NICHOLAS</creatorcontrib><creatorcontrib>GIBSON ALEXANDER MARK</creatorcontrib><creatorcontrib>KARIMI FARHAD</creatorcontrib><creatorcontrib>BOUVET DENIS RAYMOND CHRISTOPHE</creatorcontrib><creatorcontrib>LANGSTROM BENGT</creatorcontrib><creatorcontrib>JONES CLARE LOUISE</creatorcontrib><creatorcontrib>FAIRWAY STEVEN MICHAEL</creatorcontrib><creatorcontrib>NAIRNE ROBERT JAMES</creatorcontrib><creatorcontrib>WILLIAMS LORENZO</creatorcontrib><creatorcontrib>STOREY ANTHONY EAMON</creatorcontrib><title>Fluorination process</title><description>The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, -(CH2CH2O)q-CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>NUCLEAR ENGINEERING</subject><subject>NUCLEAR PHYSICS</subject><subject>NUCLEAR REACTORS</subject><subject>ORGANIC CHEMISTRY</subject><subject>PHYSICS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBBxyynNL8rMSyzJzM9TKCjKT04tLuZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGhwZaGRmaWZoZORsZEKAEANSkg6g</recordid><startdate>20150908</startdate><enddate>20150908</enddate><creator>LASBISTES NICHOLAS</creator><creator>GIBSON ALEXANDER MARK</creator><creator>KARIMI FARHAD</creator><creator>BOUVET DENIS RAYMOND CHRISTOPHE</creator><creator>LANGSTROM BENGT</creator><creator>JONES CLARE LOUISE</creator><creator>FAIRWAY STEVEN MICHAEL</creator><creator>NAIRNE ROBERT JAMES</creator><creator>WILLIAMS LORENZO</creator><creator>STOREY ANTHONY EAMON</creator><scope>EVB</scope></search><sort><creationdate>20150908</creationdate><title>Fluorination process</title><author>LASBISTES NICHOLAS ; GIBSON ALEXANDER MARK ; KARIMI FARHAD ; BOUVET DENIS RAYMOND CHRISTOPHE ; LANGSTROM BENGT ; JONES CLARE LOUISE ; FAIRWAY STEVEN MICHAEL ; NAIRNE ROBERT JAMES ; WILLIAMS LORENZO ; STOREY ANTHONY EAMON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US9126961B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>NUCLEAR ENGINEERING</topic><topic>NUCLEAR PHYSICS</topic><topic>NUCLEAR REACTORS</topic><topic>ORGANIC CHEMISTRY</topic><topic>PHYSICS</topic><toplevel>online_resources</toplevel><creatorcontrib>LASBISTES NICHOLAS</creatorcontrib><creatorcontrib>GIBSON ALEXANDER MARK</creatorcontrib><creatorcontrib>KARIMI FARHAD</creatorcontrib><creatorcontrib>BOUVET DENIS RAYMOND CHRISTOPHE</creatorcontrib><creatorcontrib>LANGSTROM BENGT</creatorcontrib><creatorcontrib>JONES CLARE LOUISE</creatorcontrib><creatorcontrib>FAIRWAY STEVEN MICHAEL</creatorcontrib><creatorcontrib>NAIRNE ROBERT JAMES</creatorcontrib><creatorcontrib>WILLIAMS LORENZO</creatorcontrib><creatorcontrib>STOREY ANTHONY EAMON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LASBISTES NICHOLAS</au><au>GIBSON ALEXANDER MARK</au><au>KARIMI FARHAD</au><au>BOUVET DENIS RAYMOND CHRISTOPHE</au><au>LANGSTROM BENGT</au><au>JONES CLARE LOUISE</au><au>FAIRWAY STEVEN MICHAEL</au><au>NAIRNE ROBERT JAMES</au><au>WILLIAMS LORENZO</au><au>STOREY ANTHONY EAMON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Fluorination process</title><date>2015-09-08</date><risdate>2015</risdate><abstract>The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, -(CH2CH2O)q-CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY NUCLEAR ENGINEERING NUCLEAR PHYSICS NUCLEAR REACTORS ORGANIC CHEMISTRY PHYSICS |
| title | Fluorination process |
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