Method of preparing biologically active formulations
The invention provides pellet for use as a core for a pharmaceutical dosage form having an inner and an outer zone where the inner zone includes a biologically active agent and said outer zone includes a layer formed by applying a substantially dry, free flowing inert powder which forms a non-tacky...
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| creator | RUBINO ORAPIN P PRASCH ARMIN BRETSCHNEIDER FRANK JONES DAVID M FANKHAUSER PETER |
| description | The invention provides pellet for use as a core for a pharmaceutical dosage form having an inner and an outer zone where the inner zone includes a biologically active agent and said outer zone includes a layer formed by applying a substantially dry, free flowing inert powder which forms a non-tacky surface when placed in contact with water. The invention also provides a process for making pharmaceutical pellets where the core or at least one a layer on the core is formed by (a) contacting powder particles, adhering them to each other and compacting the adhered pellets by a rolling movement, wherein the degree of densification is controlled by the rolling movement; and (b) feeding a sufficient amount of a substantially dry, free flowing inert powder which forms a non-tacky surface when placed in contact with water to provide on said particles an outer zone including a layer formed from said substantially dry, free flowing inert powder. |
| format | Patent |
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The invention also provides a process for making pharmaceutical pellets where the core or at least one a layer on the core is formed by (a) contacting powder particles, adhering them to each other and compacting the adhered pellets by a rolling movement, wherein the degree of densification is controlled by the rolling movement; and (b) feeding a sufficient amount of a substantially dry, free flowing inert powder which forms a non-tacky surface when placed in contact with water to provide on said particles an outer zone including a layer formed from said substantially dry, free flowing inert powder.</description><language>eng</language><subject>BABY COMFORTERS ; CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES ; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY ; DEVICES FOR RECEIVING SPITTLE ; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150818&DB=EPODOC&CC=US&NR=9107804B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150818&DB=EPODOC&CC=US&NR=9107804B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RUBINO ORAPIN P</creatorcontrib><creatorcontrib>PRASCH ARMIN</creatorcontrib><creatorcontrib>BRETSCHNEIDER FRANK</creatorcontrib><creatorcontrib>JONES DAVID M</creatorcontrib><creatorcontrib>FANKHAUSER PETER</creatorcontrib><title>Method of preparing biologically active formulations</title><description>The invention provides pellet for use as a core for a pharmaceutical dosage form having an inner and an outer zone where the inner zone includes a biologically active agent and said outer zone includes a layer formed by applying a substantially dry, free flowing inert powder which forms a non-tacky surface when placed in contact with water. The invention also provides a process for making pharmaceutical pellets where the core or at least one a layer on the core is formed by (a) contacting powder particles, adhering them to each other and compacting the adhered pellets by a rolling movement, wherein the degree of densification is controlled by the rolling movement; and (b) feeding a sufficient amount of a substantially dry, free flowing inert powder which forms a non-tacky surface when placed in contact with water to provide on said particles an outer zone including a layer formed from said substantially dry, free flowing inert powder.</description><subject>BABY COMFORTERS</subject><subject>CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES</subject><subject>DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY</subject><subject>DEVICES FOR RECEIVING SPITTLE</subject><subject>DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDxTS3JyE9RyE9TKChKLUgsysxLV0jKzM_JT89MTszJqVRITC7JLEtVSMsvyi3NSSzJzM8r5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8aHBloYG5hYGJk5GxkQoAQASvC0e</recordid><startdate>20150818</startdate><enddate>20150818</enddate><creator>RUBINO ORAPIN P</creator><creator>PRASCH ARMIN</creator><creator>BRETSCHNEIDER FRANK</creator><creator>JONES DAVID M</creator><creator>FANKHAUSER PETER</creator><scope>EVB</scope></search><sort><creationdate>20150818</creationdate><title>Method of preparing biologically active formulations</title><author>RUBINO ORAPIN P ; PRASCH ARMIN ; BRETSCHNEIDER FRANK ; JONES DAVID M ; FANKHAUSER PETER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US9107804B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2015</creationdate><topic>BABY COMFORTERS</topic><topic>CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES</topic><topic>DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY</topic><topic>DEVICES FOR RECEIVING SPITTLE</topic><topic>DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>RUBINO ORAPIN P</creatorcontrib><creatorcontrib>PRASCH ARMIN</creatorcontrib><creatorcontrib>BRETSCHNEIDER FRANK</creatorcontrib><creatorcontrib>JONES DAVID M</creatorcontrib><creatorcontrib>FANKHAUSER PETER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RUBINO ORAPIN P</au><au>PRASCH ARMIN</au><au>BRETSCHNEIDER FRANK</au><au>JONES DAVID M</au><au>FANKHAUSER PETER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method of preparing biologically active formulations</title><date>2015-08-18</date><risdate>2015</risdate><abstract>The invention provides pellet for use as a core for a pharmaceutical dosage form having an inner and an outer zone where the inner zone includes a biologically active agent and said outer zone includes a layer formed by applying a substantially dry, free flowing inert powder which forms a non-tacky surface when placed in contact with water. The invention also provides a process for making pharmaceutical pellets where the core or at least one a layer on the core is formed by (a) contacting powder particles, adhering them to each other and compacting the adhered pellets by a rolling movement, wherein the degree of densification is controlled by the rolling movement; and (b) feeding a sufficient amount of a substantially dry, free flowing inert powder which forms a non-tacky surface when placed in contact with water to provide on said particles an outer zone including a layer formed from said substantially dry, free flowing inert powder.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BABY COMFORTERS CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY DEVICES FOR RECEIVING SPITTLE DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Method of preparing biologically active formulations |
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