Use of oripavine as a starting material for buprenorphine

There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yiel...

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Hauptverfasser:	BUEHLER HENRY J, HILL LLOYD P, MANNINO ANTHONY, HOEFGIN ERIK R
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	BUEHLER HENRY J HILL LLOYD P MANNINO ANTHONY HOEFGIN ERIK R
description	There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demethylation step, since the oripavine molecule lacks an O-3 methyl group.
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title	Use of oripavine as a starting material for buprenorphine
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