Monoconjugated chitosans as delivery agents for small interfering nucleic acids
Conjugates are provided, an exemplary conjugating having a single water-soluble, non-peptidic polymer, such as a poly(ethylene oxide), attached to a chitosan. Complexes of small interfering nucleic acids formed with such conjugates as well as small interfering nucleic acids attached to such conjugat...
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| creator | MCMANUS SAMUEL P KOZLOWSKI ANTONI YOUSO PATRICK D |
| description | Conjugates are provided, an exemplary conjugating having a single water-soluble, non-peptidic polymer, such as a poly(ethylene oxide), attached to a chitosan. Complexes of small interfering nucleic acids formed with such conjugates as well as small interfering nucleic acids attached to such conjugates are also provided. Related methods, intermediates, and compositions are also provided. |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | Monoconjugated chitosans as delivery agents for small interfering nucleic acids |
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