Triazole compounds that modulate Hsp90 activity

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, s...

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Hauptverfasser: PRZEWLOKA TERESA, CHAE JUNGHYUN, BARSOUM JAMES, DU ZHENJIAN, LEE CHI-WAN, NG HOWARD P, YING WEIWEN, CHIMMANAMADA DINESH U, JAMES DAVID, ZHANG SHIJIE, FOLEY KEVIN, KOSTIK ELENA
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creator PRZEWLOKA TERESA
CHAE JUNGHYUN
BARSOUM JAMES
DU ZHENJIAN
LEE CHI-WAN
NG HOWARD P
YING WEIWEN
CHIMMANAMADA DINESH U
JAMES DAVID
ZHANG SHIJIE
FOLEY KEVIN
KOSTIK ELENA
description The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20141202&amp;DB=EPODOC&amp;CC=US&amp;NR=8901308B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20141202&amp;DB=EPODOC&amp;CC=US&amp;NR=8901308B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PRZEWLOKA TERESA</creatorcontrib><creatorcontrib>CHAE JUNGHYUN</creatorcontrib><creatorcontrib>BARSOUM JAMES</creatorcontrib><creatorcontrib>DU ZHENJIAN</creatorcontrib><creatorcontrib>LEE CHI-WAN</creatorcontrib><creatorcontrib>NG HOWARD P</creatorcontrib><creatorcontrib>YING WEIWEN</creatorcontrib><creatorcontrib>CHIMMANAMADA DINESH U</creatorcontrib><creatorcontrib>JAMES DAVID</creatorcontrib><creatorcontrib>ZHANG SHIJIE</creatorcontrib><creatorcontrib>FOLEY KEVIN</creatorcontrib><creatorcontrib>KOSTIK ELENA</creatorcontrib><title>Triazole compounds that modulate Hsp90 activity</title><description>The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. 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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Triazole compounds that modulate Hsp90 activity
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