Methods for designing, selecting and/or optimizing allosteric processing inhibitors for matrix metalloproteinases

The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit th...

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Bibliographische Detailangaben

Hauptverfasser:	JACKSON PAUL F, SCANNEVIN ROBERT H, ALEXANDER RICHARD SCOTT, KUO LAWRENCE C, LEONARD KRISTI A, BONE ROGER F, SPURLINO JOHN C, LEWANDOWSKI FRANK A, TODD MATTHEW J, DECKMAN INGRID CHRISTA, SCHALK-HIHI CELINE, TOUNGE BRETT A, MAGUIRE DIANE M, BARBAY JOSEPH KENT, RHODES KENNETH J, MILLIGAN CYNTHIA M, WANG AIHUA, SPRINGER BARRY
Format:	Patent
Sprache:	eng
Schlagworte:	INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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