Nucleobindin I variant protein compositions and methods of use

Nucleobindin I variant protein compositions and methods of use

The invention relates to Nucleobindin-1 (NUCB1) protein variants that are capable of disaggregating amyloid fibrils as well as inhibiting the formation of fibrils in the presence of physiological concentrations of calcium. Isolated NUCB1 protein variants, nucleic acids encoding the protein variants,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SAKMAR THOMAS P, KAPOOR NEERAJ, RALEIGH DAN, MENON SANTOSH T, GUPTA RUCHI
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator SAKMAR THOMAS P
KAPOOR NEERAJ
RALEIGH DAN
MENON SANTOSH T
GUPTA RUCHI
description The invention relates to Nucleobindin-1 (NUCB1) protein variants that are capable of disaggregating amyloid fibrils as well as inhibiting the formation of fibrils in the presence of physiological concentrations of calcium. Isolated NUCB1 protein variants, nucleic acids encoding the protein variants, cells comprising the isolated nucleic acids, pharmaceutical compositions and kits comprising the variants, methods of making the variants, and therapeutic uses of the variants are provided.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US8703707B2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US8703707B2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US8703707B23</originalsourceid><addsrcrecordid>eNrjZLDzK03OSc1PysxLycxT8FQoSyzKTMwrUSgoyi9JBYok5-cW5BdnlmTm5xUrJOalKOSmlmTkpxQr5KcplBan8jCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSS-NBgC3MDY3MDcycjYyKUAAAV0TCA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Nucleobindin I variant protein compositions and methods of use</title><source>esp@cenet</source><creator>SAKMAR THOMAS P ; KAPOOR NEERAJ ; RALEIGH DAN ; MENON SANTOSH T ; GUPTA RUCHI</creator><creatorcontrib>SAKMAR THOMAS P ; KAPOOR NEERAJ ; RALEIGH DAN ; MENON SANTOSH T ; GUPTA RUCHI</creatorcontrib><description>The invention relates to Nucleobindin-1 (NUCB1) protein variants that are capable of disaggregating amyloid fibrils as well as inhibiting the formation of fibrils in the presence of physiological concentrations of calcium. Isolated NUCB1 protein variants, nucleic acids encoding the protein variants, cells comprising the isolated nucleic acids, pharmaceutical compositions and kits comprising the variants, methods of making the variants, and therapeutic uses of the variants are provided.</description><language>eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20140422&amp;DB=EPODOC&amp;CC=US&amp;NR=8703707B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20140422&amp;DB=EPODOC&amp;CC=US&amp;NR=8703707B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SAKMAR THOMAS P</creatorcontrib><creatorcontrib>KAPOOR NEERAJ</creatorcontrib><creatorcontrib>RALEIGH DAN</creatorcontrib><creatorcontrib>MENON SANTOSH T</creatorcontrib><creatorcontrib>GUPTA RUCHI</creatorcontrib><title>Nucleobindin I variant protein compositions and methods of use</title><description>The invention relates to Nucleobindin-1 (NUCB1) protein variants that are capable of disaggregating amyloid fibrils as well as inhibiting the formation of fibrils in the presence of physiological concentrations of calcium. Isolated NUCB1 protein variants, nucleic acids encoding the protein variants, cells comprising the isolated nucleic acids, pharmaceutical compositions and kits comprising the variants, methods of making the variants, and therapeutic uses of the variants are provided.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDzK03OSc1PysxLycxT8FQoSyzKTMwrUSgoyi9JBYok5-cW5BdnlmTm5xUrJOalKOSmlmTkpxQr5KcplBan8jCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSS-NBgC3MDY3MDcycjYyKUAAAV0TCA</recordid><startdate>20140422</startdate><enddate>20140422</enddate><creator>SAKMAR THOMAS P</creator><creator>KAPOOR NEERAJ</creator><creator>RALEIGH DAN</creator><creator>MENON SANTOSH T</creator><creator>GUPTA RUCHI</creator><scope>EVB</scope></search><sort><creationdate>20140422</creationdate><title>Nucleobindin I variant protein compositions and methods of use</title><author>SAKMAR THOMAS P ; KAPOOR NEERAJ ; RALEIGH DAN ; MENON SANTOSH T ; GUPTA RUCHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US8703707B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2014</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SAKMAR THOMAS P</creatorcontrib><creatorcontrib>KAPOOR NEERAJ</creatorcontrib><creatorcontrib>RALEIGH DAN</creatorcontrib><creatorcontrib>MENON SANTOSH T</creatorcontrib><creatorcontrib>GUPTA RUCHI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SAKMAR THOMAS P</au><au>KAPOOR NEERAJ</au><au>RALEIGH DAN</au><au>MENON SANTOSH T</au><au>GUPTA RUCHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Nucleobindin I variant protein compositions and methods of use</title><date>2014-04-22</date><risdate>2014</risdate><abstract>The invention relates to Nucleobindin-1 (NUCB1) protein variants that are capable of disaggregating amyloid fibrils as well as inhibiting the formation of fibrils in the presence of physiological concentrations of calcium. Isolated NUCB1 protein variants, nucleic acids encoding the protein variants, cells comprising the isolated nucleic acids, pharmaceutical compositions and kits comprising the variants, methods of making the variants, and therapeutic uses of the variants are provided.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_US8703707B2
source esp@cenet
subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Nucleobindin I variant protein compositions and methods of use
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T08%3A56%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SAKMAR%20THOMAS%20P&rft.date=2014-04-22&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS8703707B2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true