Pyrrolopyrimidine compounds and their uses

The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need...

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Hauptverfasser: BESONG GILBERT EBAI, LI YUE, SUNG MOO JE, DAGOSTIN CLAUDIO, BROOKS CLINTON ALAN, HE GUO, HOWARD STEVEN, WRONA WOJCIECH, LAGU BHARAT, SMITH TROY D, WOODHEAD STEVEN JOHN, MORTENSON PAUL NEIL, BRAIN CHRISTOPHER THOMAS, CONGREVE MILES STUART, HOU YING, LU YIPIN
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creator BESONG GILBERT EBAI
LI YUE
SUNG MOO JE
DAGOSTIN CLAUDIO
BROOKS CLINTON ALAN
HE GUO
HOWARD STEVEN
WRONA WOJCIECH
LAGU BHARAT
SMITH TROY D
WOODHEAD STEVEN JOHN
MORTENSON PAUL NEIL
BRAIN CHRISTOPHER THOMAS
CONGREVE MILES STUART
HOU YING
LU YIPIN
description The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Pyrrolopyrimidine compounds and their uses
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