Process for the preparation of (poly) aminoalkylaminoacetamide derivatives of epipodophyllotoxin useful for their applications in therapeutics as anticancer agent

The present invention relates to a new process for the preparation of (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin and salts thereof, characterized in that it comprises a step of peptide coupling of 4-amino-4'-demethylepipodophyllotoxin with an amine-containing reactant havi...

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Bibliographische Detailangaben
Hauptverfasser: GROUSSEAUD MARTIAL, GUMINSKI YVES, IMBERT THIERRY
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a new process for the preparation of (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin and salts thereof, characterized in that it comprises a step of peptide coupling of 4-amino-4'-demethylepipodophyllotoxin with an amine-containing reactant having protecting groups.