Bonding tissues and cross-linking proteins with naphthalimide compounds

Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together,...

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Hauptverfasser: UTECHT RONALD E, VASKA KEVIN J, JUDY MILLARD M, MATTHEWS JAMES L, KLOSTER KAIA L
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creator UTECHT RONALD E
VASKA KEVIN J
JUDY MILLARD M
MATTHEWS JAMES L
KLOSTER KAIA L
description Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
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subjects AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
DIAGNOSIS
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
IDENTIFICATION
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
PEPTIDES
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
SURGERY
THEIR PREPARATION OR CHEMICAL WORKING-UP
TRAPPING
VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
title Bonding tissues and cross-linking proteins with naphthalimide compounds
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